Recent developments in predicting thyroid malignancy

Stang, Michael T.; Carty, Sally E.

doi:10.1097/cco.0b013e32831db2af

Cited by 43 publications

(28 citation statements)

References 61 publications

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“…A nodule size > 3-4 cm seems to be associated with a higher chance of malignancy in these cases (7), but this has not been demonstrated in all series (3,8). In the case of nodules ≥ 4 cm, our experience showed a 35% frequency of malignancy (unpublished data), a rate slightly higher than that observed in the present study for nodules < 4 cm (24%).…”

Section: Discussioncontrasting

confidence: 55%

Contribution of scintigraphy and ultrasonography to the prediction of malignancy in thyroid nodules with indeterminate cytology

Rosário

Salles

Bessa

et al. 2010

Arq Bras Endocrinol Metab

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Objective: To evaluate the contribution of 131 I scintigraphy and ultrasonography to the prediction of malignancy in thyroid nodules with indeterminate cytology in euthyroid patients. Subjects and methods: The sample consisted of 102 patients with thyroid nodules, submitted to FNAC and presenting an indeterminate cytological diagnosis (follicular neoplasm). Results: Malignancy was observed in 19/25 (76%) nodules with suspicious ultrasonographic characteristics versus 5/77 (6.5%) without suspicious findings. When 131 I scintigraphy showed a cold or hot nodule, the chance of malignancy was 38.5% and 2.5%, respectively. This exam was inconclusive in 10% of the patients. Conclusions: Surgery is indicated when a thyroid nodule with indeterminate cytology exhibits suspicious ultrasonographic characteristics. Otherwise, 131 I scintigraphy can exclude thyroidectomy when reveals uptake in the nodule, which is observed in half the cases. Arq Bras Endocrinol Metab. 2010;54(1):56-9 Keywords Thyroid nodule; indeterminate cytology; radionuclide imaging; ultrasonography resumo Objetivo: Avaliar a contribuição da cintilografia com 131 I e da ultrassonografia na predição de malignidade em nódulos tireoidianos com citologia indeterminada em pacientes eutireoidianos. Sujeitos e Métodos: A amostra foi composta por 102 pacientes com nódulos tireoidianos submetidos à punção aspirativa com agulha fina (PAAF), apresentando citologia indeterminada (neoplasia folicular). Resultados: Malignidade foi encontrada em 19/25 (76%) nódulos suspeitos na ultrassonografia versus 5/77 (6,5%) naqueles sem características suspeitas. Quando a cintilografia com 131 I mostrou nódulo hipo-ou hipercaptante, a chance de malignidade foi 38,5% e 2,5%, respectivamente, e em 10% dos pacientes esse exame foi inconclusivo. Conclusões: Cirurgia está indicada quando um nódulo tireoidiano com citologia indeterminada exibe características ultrassonográficas suspeitas. Quando não as exibe, a cintilografia com 131 I pode dispensar a tireoidectomia se revelar captação correspondente ao nódulo, o que ocorre em metade dos casos. Arq Bras Endocrinol Metab. 2010;54(1):56-9

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Section: Discussioncontrasting

confidence: 55%

Contribution of scintigraphy and ultrasonography to the prediction of malignancy in thyroid nodules with indeterminate cytology

Rosário

Salles

Bessa

et al. 2010

Arq Bras Endocrinol Metab

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“…When cytology was indeterminate (follicular neoplasm), histology revealed malignancy in 35% of cases (versus 23.5% in nodules < 4 cm, with the same cytological result and systematically operated at Santa Casa de Belo Horizonte during the period of this studyunpublished data). Nodule size has been confirmed as a predictor of malignancy in cases with indeterminate cytology in most series, but not in all (11). Most (77%) carcinomas in nodules with indeterminate cytology (follicular neoplasm) were papillary and not follicular carcinomas.…”

Section: Discussionmentioning

confidence: 88%

Low false-negative rate of cytology in thyroid nodules > 4 cm

Rosário

Salles

Bessa

et al. 2009

Arq Bras Endocrinol Metab

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Objective: To report the results of cytology and histology obtained for a series of systematically resected thyroid nodules ≥ 4 cm. Methods: A group of 151 patients with thyroid nodules ≥ 4 cm was submitted to surgery despite the cytology result. Results: Malignancy was confirmed histologically in 22.5% of the patients. Excluding cases of insufficient material, cytology was benign in only 3/31 carcinomas (90.3% sensitivity). The frequency of malignancy was 35% among nodules with indeterminate cytology (follicular neoplasm), and there was a predominance (77%) of papillary carcinoma. The negative predictive value of benign cytology was 96.4%. Conclusions: The false-negative rate of cytology in thyroid nodules ≥ 4 cm does not justify systematic resection of these nodules in asymptomatic patients with benign cytology. Arq Bras Endocrinol Metab. 2009;53(9):1143-5Keywords Thyroid nodule; cytology; benign resumo Objetivo: Reportar os resultados da citologia e da histologia em uma série de nódulos tireoidianos ≥ 4 cm sistematicamente ressecados. Métodos: Foram submetidos à cirurgia 151 pacientes com nódulo tireoidiano ≥ 4 cm, a despeito do resultado da citologia. Apenas a histologia referente a este nódulo foi considerada nos resultados. Resultados: Malignidade foi confirmada histologicamente em 22,5% dos pacientes. Excluindo os casos com material insuficiente, a citologia foi benigna somente em 3/31 carcinomas (sensibilidade 90,3%). A frequência de malignidade foi de 35% nos nódulos com citologia indeterminada (neoplasia folicular), predominando o carcinoma papilífero (77%). O valor preditivo negativo da citologia benigna foi 96,4%. Conclusões: A taxa de falso-negativo da citologia em nódulos tireoidianos ≥ 4 cm não justifica a ressecção sistemática destes em pacientes assintomáticos com citologia benigna. Arq Bras Endocrinol Metab. 2009;53(9):1143-5 Descritores Nódulo da glândula tireoide; citologia; benigna

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“…2 Thyroid nodules can be palpated in 4% to 7% of adults. 3 However, they are found incidentally in up to 40% of patients who undergo ultrasonography of the neck. 4 Some studies estimate that 20% to 76% of the population has at least one thyroid nodule.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and pattern of thyroid malignancy in thyroid nodule in Aseer Central Hospital in KSA

Hudise

Alshehri

Al-Qarni

et al. 2017

Int J Otorhinolaryngol Head Neck Surg

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Background: Thyroid nodules are common in the general population, especially in women. Non palpable nodules are often found when patients undergo diagnostic imaging such as ultrasonography and computed tomography of the chest and neck. This retrospective study to assess the Prevalence of thyroid malignancy in thyroid nodule related to gender, age, and pathology, in Aseer Central Hospital KSA. Methods: During a 5-year period (2011–2016), the medical records of 319 patients with thyroid nodules were collected from the department of pathology at Aseer Central Hospital KSA. The cases were reviewed for data on gender, age, and the pathological result. All patients underwent hemi or total thyroidectomy. Comparisons between genders, age groups, and tissue origins were performed. All statistical tests were performed with SPSS software. Results: Over a period of 5 years, a total of 319 patients: male 17.2% and female 82.8% Underwent for hemi or total thyroidectomy. The age of presentation was ranging from 14 to 80 years. Among the 319 cases of thyroid nodules 73.7% were benign nodules and 26.3% malignant nodules. Papillary thyroid carcinoma in 72.6%, follicular thyroid carcinoma 10.6%, Hurthle cell carcinoma 4.8%, anaplastic carcinoma 4.8%, thyroid lymphoma 4.8% and medullary thyroid carcinoma in 2.4%. Conclusions: Thyroid nodule is a common clinical problem and the proportion of such nodules that prove to be malignant is not small, investigations are of immense help to corroborate with the clinical and morphological finding. Papillary thyroid carcinoma most common malignant thyroid carcinoma followed by follicular thyroid carcinoma, hurthel cell carcinoma, anaplastic thyroid carcinoma, lymphoma and finally medullary thyroid Carcinoma. No significant different between male and female as risk factors for malignancy.

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Recent developments in predicting thyroid malignancy

Cited by 43 publications

References 61 publications

Contribution of scintigraphy and ultrasonography to the prediction of malignancy in thyroid nodules with indeterminate cytology

Contribution of scintigraphy and ultrasonography to the prediction of malignancy in thyroid nodules with indeterminate cytology

Low false-negative rate of cytology in thyroid nodules > 4 cm

Prevalence and pattern of thyroid malignancy in thyroid nodule in Aseer Central Hospital in KSA

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