Recent developments in Polyhydroxyalkanoates (PHAs) production – A review

Sabapathy, Poorna Chandrika; Devaraj, Sabarinathan; Meixner, Katharina; Anburajan, Parthiban; Preethi, Kathirvel; Ravikumar, Yuvaraj; Zabed, Hossain M.; Qi, Xianghui

doi:10.1016/j.biortech.2020.123132

Cited by 168 publications

(91 citation statements)

References 109 publications

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“…PHAs are a family of biopolymers, among which some types are already available on the commercial scale such as poly(3-hydrocybutyrate) and polyhydroxybutyrate-co-valerate. An overview of PHAs that are produced on industrial scale were summarized elsewhere [ 42 ]. PHAs are 100% bio-based and biodegradable.…”

Section: Bio-based Materials For Packaging Applicationsmentioning

confidence: 99%

“…Advances in molecular and genetic engineering led to the selection of several bacterial strains able to produce PHA in high amounts, over 90% of total biomass, such as Ralstonia Eutropha, or Alcaligenes Latus [ 43 ]. So far, the application of PHAs is limited due to their relatively high costs (EUR 2.2–5.0 kg −1 [ 42 ]). Thus, PHAs are mainly used for high-value applications such as pharmaceutical or medical products.…”

Section: Bio-based Materials For Packaging Applicationsmentioning

confidence: 99%

“…For industrial production, mostly pure cultures and refined substrates are used, leading to expensive PHA production. Thus, some studies investigating mixed microbial cultures and no-cost feedstock as the substrate, such as wastewater, to produce PHA were reviewed [ 42 ].…”

Section: Bio-based Materials For Packaging Applicationsmentioning

confidence: 99%

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Bio-Based Packaging: Materials, Modifications, Industrial Applications and Sustainability

et al. 2020

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Environmental impacts and consumer concerns have necessitated the study of bio-based materials as alternatives to petrochemicals for packaging applications. The purpose of this review is to summarize synthetic and non-synthetic materials feasible for packaging and textile applications, routes of upscaling, (industrial) applications, evaluation of sustainability, and end-of-life options. The outlined bio-based materials include polylactic acid, polyethylene furanoate, polybutylene succinate, and non-synthetically produced polymers such as polyhydrodyalkanoate, cellulose, starch, proteins, lipids, and waxes. Further emphasis is placed on modification techniques (coating and surface modification), biocomposites, multilayers, and additives used to adjust properties especially for barriers to gas and moisture and to tune their biodegradability. Overall, this review provides a holistic view of bio-based packaging material including processing, and an evaluation of the sustainability of and options for recycling. Thus, this review contributes to increasing the knowledge of available sustainable bio-based packaging material and enhancing the transfer of scientific results into applications.

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Section: Bio-based Materials For Packaging Applicationsmentioning

confidence: 99%

Section: Bio-based Materials For Packaging Applicationsmentioning

confidence: 99%

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Bio-Based Packaging: Materials, Modifications, Industrial Applications and Sustainability

et al. 2020

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“…In the field of PHA production, this concept was already realized for halophilic, genetically tailored strains from the genus Halomonas (10). As another trend, we currently witness dynamic development in the use of mixed microbial cultures (MMCs) for production of PHA coupled to mitigation of pollutants from waste water; here, quality control of generated PHA still is a remaining issue to be solved (11).…”

Section: Introductionmentioning

confidence: 99%

Established and advanced approaches for recovery of microbial polyhydroxyalkanoate (PHA) biopolyesters from surrounding microbial biomass

Koller

2020

The EuroBiotech Journal

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Downstream processing for recovery of microbial polyhydroxyalkanoate (PHA) biopolyesters from biomass constitutes an integral part of the entire PHA production chain; beside the feedstocks used for cultivation of PHA-production strains, this process is currently considered the major cost factor for PHA production.Besides economic aspects, PHA recovery techniques need to be sustainable by avoiding excessive use of (often precarious!) solvents, other hazardous chemicals, non-recyclable compounds, and energy. Moreover, the applied PHA recovery method is decisive for the molecular mass and purity of the obtained product, and the achievable recovery yield. In addition to the applied method, also the PHA content in biomass is decisive for the feasibility of a selected technique. Further, not all investigated recovery techniques are applicable for all types of PHA (crystalline versus amorphous PHA) and all PHA-producing microorganisms (robust versus fragile cell structures).The present review shines a light on benefits and shortcomings of established solvent-based, chemical, enzymatic, and mechanical methods for PHA recovery. Focus is dedicated on innovative, novel recovery strategies, encompassing the use of “green” solvents, application of classical “PHA anti-solvents” under pressurized conditions, ionic liquids, supercritical solvents, hypotonic cell disintegration for release of PHA granules, switchable anionic surfactants, and even digestion of non-PHA biomass by animals.The different established and novel techniques are compared in terms of PHA recovery yield, product purity, impact on PHA molar mass, scalability to industrial plants, and demand for chemicals, energy, and time.

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“…PHAs are generally produced by microorganisms as intracellular carbon and energy sources under excess carbon [ 8 ]. Nevertheless, the main challenge in large-scale PHA production and commercialisation is the cost of production which is often related to carbon feedstock, production yield and extraction processes [ 9 , 10 ]. On-going research focuses on PHA production from wastes and inexpensive substrates from agriculture and food industries [ 11 , 12 ] as well as recovery and purification using various chemical and physical processes [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Surface-Modified Highly Biocompatible Bacterial-poly(3-hydroxybutyrate-co-4-hydroxybutyrate): A Review on the Promising Next-Generation Biomaterial

et al. 2020

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Polyhydroxyalkanoates (PHAs) are bacteria derived bio-based polymers that are synthesised under limited conditions of nutritional elements with excess carbon sources. Among the members of PHAs, poly(3-hydroxybutyrate-co-4-hydroxybutyrate) [(P(3HB-co-4HB)] emerges as an attractive biomaterial to be applied in medical applications owing to its desirable mechanical and physical properties, non-genotoxicity and biocompatibility eliciting appropriate host tissue responses. The tailorable physical and chemical properties and easy surface functionalisation of P(3HB-co-4HB) increase its practicality to be developed as functional medical substitutes. However, its applicability is sometimes limited due to its hydrophobic nature due to fewer bio-recognition sites. In this review, we demonstrate how surface modifications of PHAs, mainly P(3HB-co-4HB), will overcome these limitations and facilitate their use in diverse medical applications. The integration of nanotechnology has drastically enhanced the functionality of P(3HB-co-4HB) biomaterials for application in complex biological environments of the human body. The design of versatile P(3HB-co-4HB) materials with surface modifications promise a non-cytotoxic and biocompatible material without inducing severe inflammatory responses for enhanced effective alternatives in healthcare biotechnology. The enticing work carried out with P(3HB-co-4HB) promises to be one of the next-generation materials in biomedicines which will facilitate translation into the clinic in the future.

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Recent developments in Polyhydroxyalkanoates (PHAs) production – A review

Cited by 168 publications

References 109 publications

Bio-Based Packaging: Materials, Modifications, Industrial Applications and Sustainability

Bio-Based Packaging: Materials, Modifications, Industrial Applications and Sustainability

Established and advanced approaches for recovery of microbial polyhydroxyalkanoate (PHA) biopolyesters from surrounding microbial biomass

Surface-Modified Highly Biocompatible Bacterial-poly(3-hydroxybutyrate-co-4-hydroxybutyrate): A Review on the Promising Next-Generation Biomaterial

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