Recent developments in Moringa oleifera Lam. polysaccharides: A review of the relationship between extraction methods, structural characteristics and functional activities

Yang, Min; Tao, Liang; Kang, Xin-Rui; Li, Lingfei; Chun-hua, Zhao; Wang, Zilin; Sheng, Jun; Yang, Tian

doi:10.1016/j.fochx.2022.100322

Cited by 14 publications

(9 citation statements)

References 87 publications

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“…Moringa alterniflora has promising phytoconstituents, medicinal properties, and nutritional benefits [ 13 ]. Several African and Asian countries use it as a source of food or as a raw material [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

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Polysaccharides from South Tunisian Moringa alterniflora Leaves: Characterization, Cytotoxicity, Antioxidant Activity, and Laser Burn Wound Healing in Rats

Aydi

Khadher

et al. 2023

Plants

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Phytochemical properties have recently increased the popularity of plant polysaccharides as wound dressing materials. This work aims at studying the structural characteristics of polysaccharides extracted from Moringa leaves (Moringa Leaves Water Soluble Polysaccharide: MLWSP), and its antioxidant activities, cytotoxic effects, and laser burn wound healing effects in rats. This MLWSP was structurally characterized. Results showed 175.21 KDa and 18.6%, respectively, for the molecular weight and the yield of the novel extracted polysaccharide. It is a hetero-polysaccharide containing arabinose, rhamnose, and galactose. XRD suggested a semi-crystalline structure of the studied polymer and FT-IR results revealed a typical polysaccharide structure. It is composed of 50 to 500 µm rocky-shaped units with rough surfaces and it was found to inhibit the proliferation of the human colon (HCT-116) (IC50 = 36 ± 2.5 µg/mL), breast (MCF-7) (IC50 = 48 ± 3.2), and ovary cancers (IC50 = 24 ± 8.1). The MLWSP showed significant antioxidant effects compared to Trolox (CI50 = 0.001 mg/g). Moreover, promising wound healing results were displayed. The effect of MLWSP hydrogel application on laser burn injuries stimulated wound contraction, re-epithelization, and remodeling phases 8 days after treatment. The wound healing potential of MLWSP may be due to its significant antioxidant activity and/or the huge amount of monosaccharide molecules.

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Section: Discussionmentioning

confidence: 99%

“…X-ray diffraction showed the predominance of the amorphous components of MLWSP. Additional data reported the amorphous nature of water-soluble polysaccharides [ 13 , 15 ]. As suggested by many authors, polysaccharides crystallize only into tiny crystals [ 30 , 31 , 32 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

Polysaccharides from South Tunisian Moringa alterniflora Leaves: Characterization, Cytotoxicity, Antioxidant Activity, and Laser Burn Wound Healing in Rats

Aydi

Khadher

et al. 2023

Plants

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“…21 The ferrous ion chelating activity of polysaccharides may also be attributed to the hydroxyl groups and the formation of cross-bridges between carboxyl groups in the structure of uronic acids and divalent ions of iron. 17 Moreover, polysaccharides with a high uronic acid content have high antioxidant activity, which is also ascribed to the presence of uronic acid groups that can trigger hydrogen atoms of the anomeric carbon. The higher capacity implies a stronger hydrogen atom-donating capacity, and higher uronic acid, glucose and rhamnose content shows stronger antioxidant activity.…”

Section: Effects Of Different Structures On the Bioactivity Of Polysa...mentioning

confidence: 99%

“…The available research on polysaccharide activity is scattered and without a structured and understandable review. 17 Considering this, it is urgent to thoroughly and methodically describe the variables that influence polysaccharide activity, as well as the connections between these variables and polysaccharide activity.…”

Section: Introductionmentioning

confidence: 99%

The effect of structure and preparation method on the bioactivity of polysaccharides from plants and fungi

Yang

Ren

et al. 2022

Food Funct.

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“…The leaves are healthful whether eaten fresh or cooked. Furthermore, M. oleifera leaf extracts have a variety of biological characteristics, such as antioxidants activity, hypoglycemic activity, anti-inflammatory activity, and immunomodulatory activity ( 9 , 10 ).…”

Section: Introductionmentioning

confidence: 99%

Moringa oleifera leaf polysaccharide alleviates experimental colitis by inhibiting inflammation and maintaining intestinal barrier

Husien

Peng²,

Su³

et al. 2022

Front. Nutr.

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The characteristic of ulcerative colitis (UC) is extensive colonic mucosal inflammation. Moringa oleifera (M. oleifera) is a medicine food homology plant, and the polysaccharide from M. oleifera leaves (MOLP) exhibits antioxidant and anti-inflammatory activity. The aim of this study to investigate the potential effect of MOLP on UC in a mouse model as well as the underlying mechanism. Dextran sulfate sodium (DSS) 4% in drinking water was given for 7 days to mice with UC, at the same time, MOLP (25, 50, and 100 mg/kg/day) was intragastric administered once daily during the experiment. Structural analysis revealed that MOLP had an average molecular weight (Mw) of 182,989 kDa and consisted of fucose, arabinose, rhamnose, galactose, glucose, xylose, mannose, galactose uronic acid, glucuronic acid, glucose uronic acid and mannose uronic acid, with a percentage ratio of 1.64, 18.81, 12.04, 25.90, 17.57, 12.01, 3.51, 5.28, 0.55, 1.27, and 1.43%, respectively. In addition, the features of MOLP were identified by Fourier-transform infrared (FT-IR) and spectra, X-ray diffraction (XRD). The results showed that MOLP exhibited protective efficacy against UC by alleviating colonic pathological alterations, decreasing goblet cells, crypt destruction, and infiltration of inflammatory cells caused by DSS. Furthermore, MOLP notably repressed the loss of zonula occludens-1 (ZO-1) and occludin proteins in mucosal layer, as well as up-regulating the mRNA expression of interleukin-10 (IL-10) and peroxisome proliferator-activated receptor-γ (PPAR-γ), whereas down-regulating the activation of Toll-like receptor 4 (TLR4), myeloid differentiation primary response 88 (MyD88), nuclear factor-kappa B (NF-κB) signaling pathway and the production of pro-inflammatory cytokines. Therefore, these results will help understand the protective action procedure of MOLP against UC, thereby providing significance for the development of MOLP.

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Recent developments in Moringa oleifera Lam. polysaccharides: A review of the relationship between extraction methods, structural characteristics and functional activities

Cited by 14 publications

References 87 publications

Polysaccharides from South Tunisian Moringa alterniflora Leaves: Characterization, Cytotoxicity, Antioxidant Activity, and Laser Burn Wound Healing in Rats

Polysaccharides from South Tunisian Moringa alterniflora Leaves: Characterization, Cytotoxicity, Antioxidant Activity, and Laser Burn Wound Healing in Rats

The effect of structure and preparation method on the bioactivity of polysaccharides from plants and fungi

Moringa oleifera leaf polysaccharide alleviates experimental colitis by inhibiting inflammation and maintaining intestinal barrier

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