Moringa oleifera leaf polysaccharide alleviates experimental colitis by inhibiting inflammation and maintaining intestinal barrier

Husien, Hosameldeen Mohamed; Peng, WeiLong; Su, Hongrui; Zhou, RuiGang; Tao, Ya-Xiong; Huang, Junjie; Liu, Mingjiang; Bo, Ruonan; Li, Jingui

doi:10.3389/fnut.2022.1055791

Cited by 11 publications

(3 citation statements)

References 45 publications

(54 reference statements)

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“…Standard kits from Nanjing Jiancheng Bioengineering Institute were used to check the oxidative stress markers as directed by the manufacturer. This step is referenced by Mohamed et al 20 …”

Section: Methodsmentioning

confidence: 99%

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Licorice protects against ulcerative colitis via the Nrf2/PINK1‐mediated mitochondrial autophagy

Kong

Xiang

Shi

et al. 2022

Immunity Inflam & Disease

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Purpose Study of the effects and mechanisms of licorice in the treatment of ulcerative colitis (UC) from the perspective of mitochondrial autophagy. Methods BALB/C mice were induced with 3% dextran sodium sulfate to build an animal model of UC. After 7 days of modeling, different doses of licorice were administered for 7 days. Hematoxylin and eosin staining is used to detect pathological changes in the colon. Mitochondrial membrane potentials and reactive oxygen species (ROS) contents were detected by flow cytometry, and autophagy of mitochondria was observed by transmission electron microscopy. Determination of inflammatory cytokines by enzyme‐linked immunosorbent assay. The oxidizing factors are detected by the kits. Western blot analysis was used to detect expressions for nuclear factor called erythropoietin (Nrf2), pten‐induced protein kinase 1 (PINK1), Parkin, HO‐1, P62, and LC3. Results Licorice improved the pathological condition of UC mice, increasing the mitochondrial membrane potential and decreasing the ROS content. Promotes the emergence of autophagosomes and autophagosomes. The contents of interleukin (IL)‐1β, IL‐6, IL‐17, and tumor necrosis factor‐alpha were downregulated, the contents of superoxide dismutase and glutathione peroxidase were upregulated and the contents of malondialdehyde were downregulated. In addition, licorice promotes the expression of Nrf2, PINK1, Parkin, HO‐1, P62, and LC3. Conclusion Licorice was shown to reduce levels of inflammatory factors and oxidative stress in mice with UC, possibly by promoting mitochondrial autophagy through the activation of the Nrf2/PINK1 pathway.

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“…Standard kits from Nanjing Jiancheng Bioengineering Institute were used to check the oxidative stress markers as directed by the manufacturer. This step is referenced by Mohamed et al 20 …”

Section: Methodsmentioning

confidence: 99%

“…Tumor necrosis factor α (TNF‐α), interleukin (IL)‐1β, IL‐6, and IL‐17 levels were analyzed by ELISA. This step is referenced by Mohamed et al 20 …”

Section: Methodsmentioning

confidence: 99%

Licorice protects against ulcerative colitis via the Nrf2/PINK1‐mediated mitochondrial autophagy

Kong

Xiang

Shi

et al. 2022

Immunity Inflam & Disease

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“…Furthermore, L. barbarum polysaccharide inhibits LPS-induced inflammation by upregulating PPARγ and suppressing phosphorylation of p38-MAPK, JNK, and ERK, suggesting this polysaccharide alleviating inflammatory reactions through modulation of PPARγ/MAPK/NF-κB signaling pathway ( 201 ). Similarly, Moringa oleifera leaf polysaccharide ameliorates DSS-induced colitis by enhancing PPARγ and decreasing TLR/MyD88/NF-κB signaling pathway ( 202 ). Interestingly, polysaccharides may suppress hyperlipidemia-induced inflammation by decreasing PPARγ in hyperlipidemic animals.…”

Section: Natural Compounds In Regulation Of Pparsmentioning

confidence: 99%

Natural products in atherosclerosis therapy by targeting PPARs: a review focusing on lipid metabolism and inflammation

Zhang,

Shi

et al. 2024

Front. Cardiovasc. Med.

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Inflammation and dyslipidemia are critical inducing factors of atherosclerosis. Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors and control the expression of multiple genes that are involved in lipid metabolism and inflammatory responses. However, synthesized PPAR agonists exhibit contrary therapeutic effects and various side effects in atherosclerosis therapy. Natural products are structural diversity and have a good safety. Recent studies find that natural herbs and compounds exhibit attractive therapeutic effects on atherosclerosis by alleviating hyperlipidemia and inflammation through modulation of PPARs. Importantly, the preparation of natural products generally causes significantly lower environmental pollution compared to that of synthesized chemical compounds. Therefore, it is interesting to discover novel PPAR modulator and develop alternative strategies for atherosclerosis therapy based on natural herbs and compounds. This article reviews recent findings, mainly from the year of 2020 to present, about the roles of natural herbs and compounds in regulation of PPARs and their therapeutic effects on atherosclerosis. This article provides alternative strategies and theoretical basis for atherosclerosis therapy using natural herbs and compounds by targeting PPARs, and offers valuable information for researchers that are interested in developing novel PPAR modulators.

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Environmental, industrial, and health benefits of Moringa oleifera

Mahaveerchand,

Abdul Salam

2024

Phytochem Rev

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The rise of air, water, and soil pollution poses a significant threat to global health, leading to widespread disease and premature mortality. Soil health is vital, ensuring the production of safe food, but it is compromised by pollutants such as heavy metals, pesticides, plastics, and excessive fertilization, resulting in the depletion of beneficial microorganisms and subsequently groundwater contamination. Water bodies are polluted due to contamination from industrial effluents, domestic wastewater, agricultural runoff, and oil spillage, further intensifying environmental pollution. On the other hand, atmospheric pollution, characterized by high emissions of gases, volatile compounds, greenhouse gases, not only impacts the climate but also poses serious risks to human health, leading to respiratory diseases, cardiovascular issues, and increased cancer risks. Thus, the strategic utilization of traditional plants emerges as a potent tool for environmental restoration and improving human health. The plants possess natural filtering capabilities, absorbing pollutants from air, soil, and water, thus mitigating their adverse effects. Through phytoremediation, plants can be actively used to extract and remove contaminants, contributing to detoxification and improving water and soil quality. Additionally, plants offer various health benefits. Moringa oleifera or the drumstick plant belonging to the Moringaceae family is one such indigenous plant with wide applications, that can be grown in extreme arid conditions. Since ancient times, this plant has been used for treating skin infections, anaemia, and blood impurities. This plant thrives in diverse climates addressing over 300 different aliments. Rich in phytochemicals and bioactive compounds, M. oleifera serve as a superfood, offering high nutritional values and exhibiting potential for drug development with fewer side effects. Extensive research has elucidated the diverse properties and applications of M. oleifera, however, in-depth research is needed to identify bioactive molecules, phytochemicals, and protein compounds involved, which will aid in understanding of the mechanisms of action of the plant's diverse functions. Although studies have reported several of individual M. oleifera attributes, there is no comprehensive study available addressing its diverse applications. This review covers the findings of past three decades and provides a detailed outline of M. oleifera plant and its various parts, its applications in environmental, industrial, food and health aspects documented to date.

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Moringa oleifera leaf polysaccharide alleviates experimental colitis by inhibiting inflammation and maintaining intestinal barrier

Cited by 11 publications

References 45 publications

Licorice protects against ulcerative colitis via the Nrf2/PINK1‐mediated mitochondrial autophagy

Licorice protects against ulcerative colitis via the Nrf2/PINK1‐mediated mitochondrial autophagy

Natural products in atherosclerosis therapy by targeting PPARs: a review focusing on lipid metabolism and inflammation

Environmental, industrial, and health benefits of Moringa oleifera

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