Recent Developments in Electroanalytical Chemistry of Cephalosporins and Cefamycins

Zuman, P.; Kapetanović, Vera; Aleksic, Milivoje

doi:10.1080/00032710008543225

Cited by 34 publications

(23 citation statements)

References 64 publications

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“…pH [26]. At first, we tried to optimize the experimental conditions for the CFPZ voltammetric determination.…”

Section: Resultsmentioning

confidence: 99%

“…The electro-reduction and electro-oxidation of cefoperazone as the active component of the clinical drug Cefobid have been investigated at mercury electrodes and carbon-paste electrodes using either polarography or voltammetry in connection with the linear or pulse sweep modes, including the stripping voltammetric technique [1,17,19,22,25]. Quite recently application of electro-analytical techniques in the analytical chemistry of cephalosporins has been reviewed [26].…”

Section: Introductionmentioning

confidence: 99%

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Square-wave voltammetric determination of cefoperazone in a bacterial culture, pharmaceutical drug, milk, and urine

Billová

Kizek

Jelen

et al. 2003

Analytical and Bioanalytical Chemistry

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Use of square-wave voltammetry (SWV) for determination of cefoperazone (CFPZ) in some buffers, bacterial culture, urine, and milk is described. CFPZ provides a specific voltammetric signal which is affected by pH and solution components. Determination of CFPZ in Britton-Robinson buffer, pH 4.4, is sensitive with a low detection limit (about 0.5 nmol L(-1)). In a more complex medium (bacterial 2YT medium, pH 7.2) the detection limit was approximately 1.5 micromol L(-1). We provide evidence that SWV is a suitable and quick method for CFPZ determination in a culture of living bacteria without separation of biomass. We have found big differences between methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA) in cultivation in the presence of CFPZ, depending on time. When CFPZ is cleaved by penicillinase, a new SWV peak b appears at more positive potentials. This peak rises both with increasing concentration of enzyme and with cleavage time while the original CFPZ peak is simultaneously decreasing. We determined the concentration of CFPZ in the drug Pathozone by the standard addition method and achieved good agreement with the declared value of CFPZ in the drug. With a simple pretreatment procedure it is possible to determine CFPZ in milk; for urine no pretreatment was required. Using SWV we could detect CFPZ concentrations as low as 500 nmol L(-1) in bovine milk and human urine.

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“…pH [26]. At first, we tried to optimize the experimental conditions for the CFPZ voltammetric determination.…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Square-wave voltammetric determination of cefoperazone in a bacterial culture, pharmaceutical drug, milk, and urine

Billová

Kizek

Jelen

et al. 2003

Analytical and Bioanalytical Chemistry

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“…15−19 The second reduction process is well known to take place at high negative potentials. 18 At pH 11, the additional peaks were observed at more positive potentials from that of the first reduction peak of CP ( Figure 2C). One of the additional peaks was obtained at -0.780 V. At pH 11, the amino group of CP is probably unprotonated.…”

Section: The Voltammetric Behavior Of Cpmentioning

confidence: 97%

“…16 For the reduction of CP, the postulated mechanism by Jain et al 16 was agreed with that by Reddy et al 15 For the voltammetric determination of CP in CTAB (2.810 mol dm −3 -0.7110 −6 mol dm −3 ), the first reduction peak (wave I) was used by Jain et al 16 In fact, CP molecule has two electroactive sites (methoxyimino group and unsaturated C=C bond, see Scheme 1). 17,18 Zuman et al reported the electroanalytical chemistry of cephalosporins and cefamycins. 18 The reduction of the unsaturated C=C bond occurs in two-electron process at potentials only slightly more positive than the reduction of H + ions from the supporting electrolyte used.…”

mentioning

confidence: 99%

“…18 The reduction of the unsaturated C=C bond occurs in two-electron process at potentials only slightly more positive than the reduction of H + ions from the supporting electrolyte used. 18 The reduction of CP on the static mercury electrode in the pH range of 1.8−13.0 was also studied by Aleksic et al 19 They reported 19 that the C=N-OCH 3 group was reducible in the whole pH range investigated (1.8−13.0). In acidic and neutral medium, pH<7, one well developed and sharp voltammetric peak (I) was present.…”

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confidence: 99%

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Anaerobic Hydrolytic Degradation of Cefpodoxime Proxetil in the Presence of UV Irradiation and in Darkness: Kinetics and pH Effect

Bíçer¹,

Özdemir²,

Özdemír³

2013

Croat. Chem. Acta

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Abstract. In this study, the anaerobic hydrolytic degradation of cefpodoxime proxetil (CP) in the presence of UV-light irradiation and in darkness has been studied at Britton-Robinson (B-R) buffer solutions (pH 2.5-11) by cyclic and square-wave voltammetry techniques. By means of these electrochemical techniques, the hydrolytic degradation of CP was successfully followed. The pH effect on this degradation was also investigated. In darkness, the decrease in the peak current of CP was not practically observed at the acidic and physiological pHs (2.5, 5.0 and 7.4). But, in the basic medium (pH 9.0 and 11.0), a decrease in the peak current was detected. On the other hand, UV irradiation caused a decrease in the peak current of CP and a positive shift in its cathodic peak potential. Under the UV irradiation, the maximum stability of CP was observed in B-R buffer of pH 5. It has been determined that UV irradiation has a great effect on hydrolytic degradation of CP at basic medium. On the other hand, at pHs  7.4, a new peak has been also obtained at more positive potential than that of the first reduction peak of CP. The current of this peak increases by increasing UV irradiation time. This peak could be assigned to the reduction of a new electroactive product which was formed from the hydrolytic degradation of CP under UV irradiation. The hydrolytic degradation reaction of CP followed pseudo-first order kinetics.(doi: 10.5562/cca2071)

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Current examples of practical and fundamental applications of DC polarography

Zuman

2006

J Solid State Electrochem

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Recent Developments in Electroanalytical Chemistry of Cephalosporins and Cefamycins

Cited by 34 publications

References 64 publications

Square-wave voltammetric determination of cefoperazone in a bacterial culture, pharmaceutical drug, milk, and urine

Square-wave voltammetric determination of cefoperazone in a bacterial culture, pharmaceutical drug, milk, and urine

Anaerobic Hydrolytic Degradation of Cefpodoxime Proxetil in the Presence of UV Irradiation and in Darkness: Kinetics and pH Effect

Current examples of practical and fundamental applications of DC polarography

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