Recent developments in dermoscopy for dermatology

Chen, Xi; Lu, Quansheng; Chen, Can; Jiang, Guan

doi:10.1111/jocd.13846

Cited by 23 publications

(24 citation statements)

References 46 publications

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“…Dermoscopy is a noninvasive diagnostic technique that allows the in vivo examination of skin micro-structures that are not visible to the naked eye, from the epidermis to the superficial dermis. 12 Generalized erythema, yellowish structureless patches, arborizing telangiectasias, and white scar-like areas appear to be typical dermoscopic hallmarks of neutrophilic-rich granulomatous inflammation, including leishmaniasis and deep mycosis. 13 In our study, dermoscopy reveals generalized erythema, clustered pustules, a yellowish structureless area, and vellus hair loss.…”

Section: Discussionmentioning

confidence: 99%

Dynamic Observation of Atypical Sporotrichosis Before and After Itraconazole Treatment by Dermoscopy

Tang

Zhou

Chen

et al. 2023

CCID

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Sporotrichosis is a deep fungus infection caused by the Sporothrix . In China, the most common species is Sporothrix globosa which is difficult to treat with most antifungal drugs. Atypical clinical forms of sporotrichosis can be a hinder to clinicians for an early diagnosis and treatment. We report a case of fixed cutaneous sporotrichosis of the face caused by S. globosa in a healthy adult that was initially misdiagnosed as rosacea due to its unusual clinical features. We made an effort to dermoscopically track changes in skin lesions both before and after treatment, confirming that itraconazole was effective in the treatment of sporotrichosis.

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Section: Discussionmentioning

confidence: 99%

Dynamic Observation of Atypical Sporotrichosis Before and After Itraconazole Treatment by Dermoscopy

Tang

Zhou

Chen

et al. 2023

CCID

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“…Dermoscopy is a highly practical and effective tool that waives the need for histopathological confirmation in the diagnosis of a myriad of diseases [28]. Nail psoriasis represents a significant challenge due to its association with uncertainty in its diagnosis, especially in isolated cases [1].…”

Section: Discussion/conclusionmentioning

confidence: 99%

Dermoscopic Features of Nail Psoriasis: Revisited

Yorulmaz¹,

Aksoy²

2022

Skin Appendage Disord

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Introduction: Nail psoriasis poses a diagnostic challenge in a context of clinical findings that are not evident. We aimed at exploring dermoscopic findings of nail psoriasis and assessing the relationship between these features with disease severity and the risk of arthritis. Methods: We enrolled 35 patients (26 men, 9 women) with severe nail psoriasis (Nail Psoriasis Severity Index [NAPSI] score of more than 50). A complete clinical evaluation, including musculoskeletal assessment and videodermoscopic examination of all nails, was carried out for each patient. Results: Splinter haemorrhage was the most common finding (94.3%), followed by distal onycholysis (88.6%) and pitting (74.3%). The presence of subungual hyperkeratosis (SUH) and the absence of mottled lunula were associated with disease severity (p < 0.05). Both SUH and nail plate crumbling (NPC) were observed more in patients with arthritis. The presence of a combination of SUH and NPC was associated to a 15-fold increase in the risk of arthritis (%95 confidence intervals: 1.55–145.2, p < 0.05). Discussion/Conclusion: This study presents preliminary evidence for the use of dermoscopy as a first step in the diagnosis of nail psoriasis. Dermoscopy is an indispensable tool in the primary evaluation of patients with nail psoriasis, which provides predictive information about the course of the disease.

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“…202200064 Intravital microscopy (IVM) in particular [2][3][4][5] has been gaining interest as it allows dynamic serial imaging of specific cells, [6] biological processes, and drug action [7,8] in an intact microenvironment. Borrowing concepts from IVM, clinical counterparts such as fluorescence guided surgery, [9] dermoscopy, [10] and confocal endomicroscopy [11] have also been developed in the hope to ultimately perform molecular analyses in vivo ("optical biopsies"). [12] Current fluorescence IVM approaches typically harness the entire optical spectrum and combined with fluorescent reporters allow imaging of approximately four to six targets in vivo before spectral overlap becomes a technical limitation.…”

Section: Introductionmentioning

confidence: 99%

In Vivo Click Chemistry Enables Multiplexed Intravital Microscopy

Lucas

Köhler

et al. 2022

Advanced Science

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The ability to observe cells in live organisms is essential for understanding their function in complex in vivo milieus. A major challenge today has been the limited ability to perform higher multiplexing beyond four to six colors to define cell subtypes in vivo. Here, a click chemistry-based strategy is presented for higher multiplexed in vivo imaging in mouse models. The method uses a scission-accelerated fluorophore exchange (SAFE), which exploits a highly efficient bioorthogonal mechanism to completely remove fluorescent signal from antibody-labeled cells in vivo. It is shown that the SAFE-intravital microscopy imaging method allows 1) in vivo staining of specific cell types in dorsal and cranial window chambers of mice, 2) complete un-staining in minutes, 3) in vivo click chemistries at lower (μm) and thus non-toxic concentrations, and 4) the ability to perform in vivo cyclic imaging. The potential utility of the method is demonstrated by 12 color imaging of immune cells in live mice.

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Recent developments in dermoscopy for dermatology

Cited by 23 publications

References 46 publications

Dynamic Observation of Atypical Sporotrichosis Before and After Itraconazole Treatment by Dermoscopy

Dynamic Observation of Atypical Sporotrichosis Before and After Itraconazole Treatment by Dermoscopy

Dermoscopic Features of Nail Psoriasis: Revisited

In Vivo Click Chemistry Enables Multiplexed Intravital Microscopy

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