Recent Developments in Controlled Release of Antibiotics

Abstract

Traditional use of antibiotics through injection or oral ingestion has many disadvantages, such as detrimental side effects in the host, less effectiveness, high and repeated doses, and development of drug resistance. For prevention and treatment of implant-associated infections, the continuous local delivery of antibiotics is required. Thus, there is a strong demand for the development of drug carrier systems to control the release of antibiotics in a moderate manner over an appropriate timescale. This review summarizes the carrier platforms used for the loading of antibiotics, and highlights their drug release behaviors as well as in vitro and in vivo antibacterial properties.

Docetaxel‐loaded scaffolds manufactured by 3D printing as model, biodegradable prostatic stents

“…However, they were prepared from strips of cut polymeric films which were then wounded on a glass rod to form stents. After that, stents were immersed in a solution of paclitaxel overnight 36 . Shin et al developed metallic urethral stents loaded with paclitaxel.…”

“…After that, stents were immersed in a solution of paclitaxel overnight. 36 Shin et al developed metallic urethral stents loaded with paclitaxel. They were aimed to reduce stentrelated tissue hyperplasia.…”

Advancement of Gallium and Gallium-Based Compounds as Antimicrobial Agents

“…Therefore, it is difficult to release adequate quantities of gallium (III) to play an antibacterial role due to its extremely low bioavailability (Bonchi et al, 2014). In contrast, the prevention and treatment of iatrogenic infections caused by implants or internal incisions requires the maintenance of antimicrobial agent concentrations above the minimum inhibitory concentration (MIC) at the infection foci, and the explosive release of an element in a short period of time would hardly meet the clinical needs (Zhang et al, 2015;Shao et al, 2016;Ning et al, 2018).…”

Artificial Gastrointestinal Models for Nutraceuticals Research—Achievements and Challenges: A Practical Review

“…These include the intake of probiotic, prebiotic, or synbiotic preparations that combine the two former ones [89]. Another method that can be used in parallel is using drugs containing ingredients that allow control of their release in the gastrointestinal tract, thus preventing excessive disturbances in intestinal microbiota composition [90].…”