Docetaxel‐loaded scaffolds manufactured by 3D printing as model, biodegradable prostatic stents

Abstract

The first-line therapy against locally advanced prostate cancer is radical prostatectomy as well as radiation therapy which might contribute to the swelling of the prostate. To prevent this, prostatic urethral stents might be used and they are mostly made of metal alloys. However, biodegradable prostatic stents are constantly explored. The aim of the study was 3D printing of tubular biodegradable scaffolds intended as a model prostatic stent since 3D printing allows obtaining devices with controlled geometric shape and function. Additional docetaxel-loaded layers on bioresorbable scaffolds were obtained for local chemotherapeutic delivery. Scaffolds were characterized before and during incubation in artificial urine for 6 weeks. Changes in the chain microstructure of

Formation of Three‐Dimensional Polysuccinimide Electrospun Fiber Meshes Induced by the Combination of CaCl2 and Humidity

“…[24] The addition of calcium chloride to PSI fibers resulted in an increase of amorphous halo between 40 and 60 2Θ degrees, with some small peaks corresponding to the crystalline state of CaCl 2based hydrates. The lack of a high number of peaks shows that the dispersion of CaCl 2 and its hydrates is uniform, similarly as was described by Jaworska et al [58] These findings support our previous hypothesis and indicate that the solidification of PSI and CaCl 2 mainly occurs simultaneously. These results lead us to the assumption that CaCl 2 induces the early solidification of the polymer jet, which can be related to the 3D mesh formation.…”