Recent developments in chemistry, coordination, structure and biological aspects of 1-(acyl/aroyl)-3-(substituted) thioureas

Abstract

1-(Acyl/aroyl)-3-(substituted)thioureas are privileged architectures that have received remarkable attention of researchers in view of their variable topological aspects, binding modes and broad spectrum promising pharmacological properties. Reactivity of acyl thiourea derivatives has presented various organic transformations into other demanding scaffolds and this is an attractive strategy for synthetic chemists to access heterocyclic cores. Multiple binding sites make them flexible ligands for complexation with transition metals thus occupying a distinct position in coordination chemistry. 1-(Acyl/aroyl)-3-(substituted)thioureas have also emerged as attractive candidates in various fields such as ion sensors, corrosion inhibitors, molecular electronics, in metal extraction and in pharmaceuticals. The medicinal chemistry of this organo-sulfur framework and the derived metal complexes has witnessed fantastic progress in the current era. In continuation of our efforts to compile data on the structural aspects and numerous applications of 1-(acyl/aroyl)-3-(substituted)thiourea analogs, continuous advances have prompted us to present an overview of the last 2 years literature on this exciting family of compounds through this review article.

Synthesis, Characterization, Anticancer and Antimicrobial Activity Studies of Novel Isomeric 2,4‐Disubstituted Ureide Derivatives of Pyrimidinopiperidines

“…Urea derivatives possess interesting activities such as antimicrobial, anticancer and as anaplastic lymphoma kinase (ALK) inhibitors . Urea and thiourea derivatives are also reported to possess a broad spectrum of biological activities such as antibacterial, antifungal, antiviral, anticancer, anticonvulsant, analgesics and as High density lipoprotein (HDL) elevating agents.…”

Crystal structure of bis(2-((allylcarbamothioyl)imino)-4-methylthiazol-3-ido-κ2 N,S)palladium(II), C16H20N6PdS4

“…Many reports have documented the ability of thioureas to coordinate transition metals such as Ni(II), Cu(II), Co(II), Fe(III) [5,6], Zn(II) [7], Pd(II) [8], and Ru(II) [9]. Their diversified use has received attention by various scientific communities including medical [10], analytical chemistry and metallurgy fields [11]. To name a few, they have been used in antiviral [12,13], anti-HIV [14], antimicrobial, antitumor, anti-inflammatory [15], and insecticidal substances [16].…”

Novel N‐Acyl‐1H‐imidazole‐1‐carbothioamides: Design, Synthesis, Biological and Computational Studies

“…TU derivatives possess higher chemical reactivity, hence used as a precursor for the synthesis of bio‐inspired heterocycles. TU based heterocycles include thiohydantoins, iminothiazolidinones, imidazole‐2‐thiones, thiazolines and thiazolamines associated with a broader spectrum of synthetic and biological applications . TU pharmacophores possess specific binding sites like hydrogen binding area (NH), complementary area (S) and auxiliary binding area (1,3‐substituents) .…”

“…TU based heterocycles include thiohydantoins, iminothiazolidinones, imidazole-2-thiones, thiazolines and thiazolamines associated with a broader spectrum of synthetic and biological applications. [11,12] TU pharmacophores possess specific binding sites like hydrogen binding area (NH), complementary area (S) and auxiliary binding area (1,3-substituents). [13] This favorable pharmacokinetic profile impart TU based heterocycles potent biological applications including antimalarial, [14] antitubercular, [15] anti-HIV, [16] analgesic [17] and anticancer.…”