Recent developments in aromatic heteroatom coupling reactions

Recent Uses of Palladium Chemistry in Indole Synthesis

“…They varied the reaction condition to get a fair yield for the substituted indole, and explore the possibility of cyclization using solid-liquid phase transfer conditions, Pd(OAc) 2 /Bu 4 NCl/NaHCO 3 / DMF, at 25 o C. (67) with selective isomerization of a double bond followed by 5-endo cyclization was demonstrated by Watanabe et al [64]. Dajka-Halasz et al [65] described the synthesis of 5H-pyridazino[4,5-b]indole (71) by two stage approach a) nuleophilic substitution or a selective Buchwald-Hartwig reaction (C-N bond formation) [66][67][68][69][70][71][72][73] followed by b) intramolecular Heck-cyclization.…”

Aryl Carbon–Heteroatom Coupling Reactions Using Nanometal Catalyst

“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14] The classical method for the synthesis of aryl sulfides involves condensation of aryl halides with thiols requiring strongly basic and harsh reaction conditions. 15 This leads to the development of transition metal-catalyzed processes, which offer more efficient coupling under milder conditions.…”

Isolation, Biological Activities and Synthesis of Indoloquinoline Alkaloids: Cryptolepine, Isocryptolepine and Neocryptolepine

“…This approach consists of two consecutive Pd-catalyzed reactions -a selective Buchwald-Hartwig [58][59][60][61][62][63] reaction of 2chloroaniline 34 with 4-chloroquinoline 33 followed by an intramolecular arylation [64][65][66] of the resulting compound 35 to afford the 11H-indolo[3,2-c]quinoline 16.…”