Recent developments in antibacterial and antifungal chitosan and its derivatives

Verlee, Arno; Mincke, Stein; Stevens, Christian V.

doi:10.1016/j.carbpol.2017.02.001

Cited by 675 publications

(423 citation statements)

References 165 publications

Supporting

Mentioning

399

Contrasting

Unclassified

Order By: Relevance

“…As a key component of many cosmetic, pharmaceutical, and nutraceutical products, chitosan has been numerously used to synthesise a wide range of advanced health materials and delivery systems 8 including nanoparticles 9,10 polymeric films 11 , nanogel 12 , nanospheres 13 , nanofibers 14 , nanocomposites, porous membranes 15 and mucoadhesive sheets.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2018

IJPSR

View full text Add to dashboard Cite

ABSTRACT:Chitosan is a natural biopolymer that has been extensively used traditionally for the treatment of various ailments and as an efficient vehicle or carrier for fabrication, encapsulation and target-specific delivery of a wide range of pharmacological moieties for improved therapeutic efficacy. Despite of numerous characteristic features, the pharmaceutical significance of chitosan is limited due to its poor water solubility. The present study was aimed to investigate the impact of enzyme (hemicellulase)-mediated hydrolysis on the physicochemical characteristics including solubility, physicochemical nature, crystallinity, contact angle/wettability and surface morphology of the WSC. The sustainability of enzymatic method was evaluated by testing aqueous solubility and carrying out fourier-transform infrared spectroscopy (FTIR), x-ray diffraction (XRD), thermogravimetric analysis (TGA), contact angle measurement and scanning electron microscopic (SEM) analysis. Results of solubility studies revealed that hemicellulase-mediated hydrolysis significantly enhanced the aqueous solubility and wettability of the chitosan and exhibited smaller contact angle (θ) in comparison to the unmodified LMWCS. FTIR analysis showed that WSC synthesised via enzymatic hydrolysis exhibited ultralow molecular weight and increased deacetylation degree in comparison to the unmodified LMWCS. Moreover, there was no change in chemical nature of all the functional groups. XRD analysis indicated that the increased in crystallinity of the WSC after enzymatic degradation, however, solubility of WSC was not affected. These findings indicated that hemicellulase-mediated hydrolysis of LMWCS is an efficient alternative method to synthesise WSC without altering its physicochemical nature and pharmaceutical integrity.

show abstract

Section: Introductionmentioning

confidence: 99%

Untitled

2018

IJPSR

View full text Add to dashboard Cite

show abstract

“…Despite its antibacterial activity has been widely investigated with concern to vegetative microorganism [14][15][16], there are still no literature data about chitosan effectiveness against HRMS. For this reason, the 5.…”

Section: Introductionmentioning

confidence: 99%

Inhibiting and Inactivating Effect of Chitosan on Heat Resistant Moulds Responsible for Spoilage of Pasteurized Fruit Products

Sa¹,

Berni²

2017

J Food Process Technol

View full text Add to dashboard Cite

The antimicrobial properties of chitosan, a deacetylated derivative of chitin, were assessed in a synthetic medium and in a blueberry and red grape juice against six heat resistant moulds (HRM) associated with food spoilage, in order to evaluate its use as a potential food preservative of natural origin. In both synthetic medium and natural substrate, the Minimum Inhibitory Concentration (MIC) of chitosan proved to vary in a wide range, regardless to both fungal genus and medium considered. Although Aspergillus neoglaber, Talaromyces bacillisporus and Aspergillus niger proved most resistant to chitosan (MIC > 5000 mg/L) on both media, a marked difference was detected for other strains tested. On HRM inoculated in MEB, the MIC was equal to 100 mg/L for Byssochlamys fulva or Monascus floridanus, and to 1000 mg/L for Talaromyces macrosporus. On HRM inoculated in blueberry and red grape juice, the MIC was equal to 2500 mg/L for Byssochlamys fulva or Monascus floridanus, and to 5000 mg/L for Talaromyces macrosporus.If combined with thermal treatment (80°C for 5 min) at a concentration (500 mg/L) that did not prove effective in inhibiting fungal spores, chitosan did not affect spore survival of microorganisms tested, thus allowing the spoilage of tested fruit juice after 5 days at 30°C. Also heat resistance parameters of a selected heat-resistant strain, T. bacillisporus, were not significantly affected by supplementation of blueberry and red grape juice with 500 mg/L of chitosan, D values ranging between 47.6 and 71.4 minutes at 82°C; 13.3 and 23.3 minutes at 85°C; 3.6 and 5.9 minutes at 88°C; 0.9 and 1.8 minutes at 91°C (z=5.2°C to 5.5°C). Since chitosan did not prove effective alone or combined with thermal treatment either to inactivate heat resistant microorganisms tested or to modify heat-resistance parameters of a heat resistant mould such as T. bacillisporus, its use cannot be considered as an interesting strategy to apply milder thermal treatments and to achieve stability of acid products. aim of this study was: (i) to assess the inhibiting and inactivating effect of chitosan on heat resistant Fungi, representing a matter of concern for manufacturers of pasteurized fruit products, and to test the synergistic effect of chitosan and thermal treatments on (ii) survival and (iii) heatresistance parameters of selected strains, to evaluate its possible use as a technological aid during the pasteurization of fruit-based products. Inhibiting and Inactivating Effect of Chitosan on Heat Resistant Moulds Materials and Methods MicroorganismsThis study was carried out on different microbial strains:

show abstract

“…In the case of Gram negative bacteria, there are two mechanisms which are believed to be active at the outer membrane (Verlee et al, 2017). The first mechanism is linked to the chelation effect of chitosan with different cations when the pH is above the pK a (Bassi et al, 1999;Goy et al, 2009;Wang et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

“…The mode of action of chitosan is influenced by different factors such as its molecular weight Park et al, 2008Park et al, , 2011Zheng & Zhu, 2003) and degree of deacetylation (Verlee et al, 2017), as well has type of microorganism. Some works reported that chitosan is most active at the cell surface of fungi or bacteria leading to permeabilization (Verlee et al, 2017), thus leading to leakage of intracellular material resulting in cell death (Chung & Chen, 2008;Costa et al, 2012;Liu et al, 2004;Raafat et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Different strategies to obtain antimicrobial biodegradable films for food applications, using starch and/or chitosan with or without essential oils

Valencia-Sullca¹,

Encarnación²

View full text Add to dashboard Cite

CONSIDERAN: que la memoria titulada "DIFFERENT STRATEGIES TO OBTAIN ANTIMICROBIAL BIODEGRADABLE FILMS FOR FOOD APPLICATIONS, USING STARCH AND/OR ACKNOWLEDGEMENTSPrimero y antes que nada, dar gracias a Dios, por estar conmigo en cada paso que doy, por fortalecer mi corazón e iluminar mi mente y por haber puesto en mi camino a aquellas personas que han sido mi soporte y compañía durante todo el periodo de estudio.Agradecer hoy y siempre a mis amados padres Elena y Ubaldo porque a pesar de no estar presentes físicamente, se que procuran mi bienestar desde mi país, Perú, y esta claro que, si no fuese por el esfuerzo realizado por ellos, mis estudios realizados no hubiesen sido posible. A mis hermanos Maritza, Joaquín, Iris, Ismael, y mis sobrinos, porque a pesar de la distancia, el ánimo, cariño, apoyo y alegría que me brindan me dan la fortaleza necesaria para seguir adelante. Mi padrino Gerardo y Lucia por su cariño, consejos y hospitalidad durante mi estadia en Barcelona, los aprecio mucho.Gracias al Gobierno del Perú, especificamente al Ministerio de Educación con el programa de Becas Pronabec, por la gran oportunidad de poder realizar mis estudios de doctorado en Valencia-España.Muchas gracias de corazón Dra Amparo Chiralt, Dra. Lorena Atarés y Dra. Maria Vargas por abrirme las puertas del grupo de investigación y darme su confianza y por permitirme aprender y trabajar a su lado. La experiencia y conocimiento de cada una de ustedes ha sido muy enriquecedor para mi formación academica. Les estare por siempre agradecida.Gracias al "Laboratoire d'Ingénierie et des Biomolécules" y en especial al Dr. Laura Sanchez Gonzalez y la Dra. Elmira Arab Tehrany de la Université de Lorraine.Ha sido una experiencia inolvidable haber podido compartir mi estancia con ustedes. Merci beaucoup!!!!!!!! Gracias Cristhian Rodriguez por tu apoyo, aliento y cariño incodicional durante estos años, siempre te estare agradecida y a toda tu linda familia en especial a tus padres Berta y Gilberto. Gracias por su cariño, animos y amistad, los llevo en mi corazón y en mis oraciones.A todos mis amigos muy cercanos que he sentido su compañía durante estos años. Gracias: Gina, Rosario, Jonathan, Nohemi, Cesár, Willy, Luz, Carmen, Paul, Sandrita, Danitza, Fernando, Jesus, Rosmery, Ronny, Mauricio, Nestor, Ines, etc, asimismo, algunos becarios de pronabec que ha sido un gusto conocerlos y compartir experiencias y conocimientos con ustedes, gracias por su amistad:Mirian, Estefany, Daysi, Galo, Elio, Edwin, Eva, Oscar..etc.Gracias Robert Valverde por tu apoyo, cariño y animos, asimismo, gracias a tu linda familia, ha sido una bendición conocerlos, mi estancia en Nancy-Francia ha sido y será la mejor experiencia que he tenido, nunca lo olvidare los llevo en mi corazón. Gracias totales. Asimismo, gracias Silvia, Madeleine, Vilma, Juanca, Nahuel, Viviana..ha sido un gusto conocerlos y compartir momentos lindos, gracias por su amistad y cariño..y al grupo latino de los miercolitos gracias por su linda amistad y momentos compartidos en Nancy, gracias: Mag...

show abstract

Recent developments in antibacterial and antifungal chitosan and its derivatives

Cited by 675 publications

References 165 publications

Untitled

Untitled

Inhibiting and Inactivating Effect of Chitosan on Heat Resistant Moulds Responsible for Spoilage of Pasteurized Fruit Products

Different strategies to obtain antimicrobial biodegradable films for food applications, using starch and/or chitosan with or without essential oils

Contact Info

Product

Resources

About