Recent developments, characteristics and potential applications of screen-printed electrodes in pharmaceutical and biological analysis

Couto, Rosa A. S.; Lima, José L.F.C.; Quinaz, M. Beatriz

doi:10.1016/j.talanta.2015.06.011

Cited by 209 publications

(135 citation statements)

References 118 publications

(158 reference statements)

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“…Printed electronics presents a successful approach to develop low-cost solutions, with the possibility to increase the level of standardization, to reduce sample volumes required for each analysis and to customize the surface for a more efficient functionalization. In particular, literature reports different studies based on screen printing (also defined as thick film printing) to realize electrochemical sensors addressing the sensitive and specific quantification of different proteins and biomolecules [4], [5].…”

mentioning

confidence: 99%

Wireless Point-of-Care Platform With Screen-Printed Sensors for Biomarkers Detection

Tonello

Abate

Borghetti

et al. 2017

IEEE Trans. Instrum. Meas.

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Abstract-Measurement systems for early and reliable detection of degenerative diseases, such as Alzheimer's disease (AD), are extremely important in clinical diagnosis. Among these, biochemical assays represent a commonly used method to distinguish patients from healthy population thanks to the sensitive recognition of specific biomarkers in biological fluids. In order to overcome actual limitations of these techniques in term of cost, standardization, and sensitivity, this study aimed to realize a low-cost highly sensitive portable point-of-care (PoC) testing system based on screen-printed electrochemical sensors. The development of the platform specifically included both the design of the sensing probe and the electronic circuit devoted to condition and acquires the transduced electric signal. The designed circuit was implemented in a printed circuit board and interfaced to a wireless system based on bluetooth data transmission in order to improve the portability of the proposed solution. Preliminary results were obtained by using controlled concentrations of electrolytic solutions and calibrating the sensors for antibodies and for a well-known protein (i.e., interleukin 8) quantified by anodic stripping voltammetry (ASV). Findings from ASV measurements showed a sensitivity of 38 µA/(ng/ml) with a tested range from 1.25 to 20 ng/ml, with a limit of detection of 2 ng/ml. Further investigation will include the validation of this PoC device by testing the concentration of a specific p53 protein isoform, which was recently identified to early correlate to AD development.

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mentioning

confidence: 99%

Wireless Point-of-Care Platform With Screen-Printed Sensors for Biomarkers Detection

Tonello

Abate

Borghetti

et al. 2017

IEEE Trans. Instrum. Meas.

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“…in a solvent (e.g., cyclohexanone, mesitylene, etc.). [10][11][12][13][14][15] Manual, semi-automatic, or automatic screen-printing may be employed using inks prepared from raw materials or purchased from commercial sources. Pre-and custom-designed screen-printed electrodes are also available from several manufacturers.…”

mentioning

confidence: 99%

Use of Redox Probes for Characterization of Layer-by-Layer Gold Nanoparticle-Modified Screen-Printed Carbon Electrodes

Bishop

Ahiadu

Smith

et al. 2016

J. Electrochem. Soc.

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The electrochemical characteristics of bare and surface-modified screen-printed carbon electrodes (SPCEs) were compared using voltammetric responses of common redox probes to determine the potential role of nanomaterials in previously documented signal enhancement. SPCEs modified with gold nanoparticles (AuNPs) by layer-by-layer (LbL) electrostatic adsorption were previously reported to exhibit an increase in voltammetric signal for Fe(CN) 6 3−/4− that corresponds to an improvement of 102% in electroactive surface area over bare SPCEs. AuNP-modified SPCEs prepared by the same LbL strategy using the polycation poly(diallyldimethylammonium chloride) (PDDA) here were found to provide no beneficial increase in electroactive surface area over bare SPCEs. Though similar improvement in voltammetric signal of Fe(CN) 6 3−/4− was found for AuNP/PDDA-modified compared to bare SPCEs in these studies, results with other redox couples ferrocene methanol (FcMeOH/FcMeOH + ) and Ru(NH 3 ) 6 3+/2+ indicated no difference between the electroactive surface areas of modified and bare SPCEs. Furthermore, gold present on AuNP/PDDAmodified SPCEs accounted for only 62 (±12)% of the electroactive surface area. The previously reported improvement in electroactive surface area that was attributed to the inclusion of AuNPs on the SPCE surface appears to have resulted from a misinterpretation of the non-ideal behavior of Fe(CN) 63− as a redox probe for bare SPCEs.

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“…Screen-printed electrodes (SPEs) are planar low-cost devices where all three electrodes of a common electrochemical cell (working, counter, and pseudo-reference) are placed on the same substrate (plastic, ceramic or textile). [1][2][3] This type of device has several desirable characteristics, such as being mass produced (low cost), simplicity, flexible selectivity (possible construction with different materials), and allow analysis with minimal sample volumes and, consequently, with minimal waste production. Most importantly such an approach allows the translation of laboratory based electrochemical systems into the field.…”

Section: Introductionmentioning

confidence: 99%

An Overview of Recent Electroanalytical Applications Utilizing Screen‐Printed Electrodes Within Flow Systems

et al. 2020

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This review addresses the use of screen-printed electrodes (SPEs) coupled to flow systems such as flow injection analysis (FIA), batch injection analysis (BIA), and high-performance liquid chromatography (HPLC) systems over the last six years (since 2014). The combination of SPEs and flow systems is a powerful synergy to increase the throughput of measurements, improve electrode lifetime, and reduce reagent consumption and waste generation. Recently, commercial flow cells for SPEs were made available by different companies and potential new users that are unable to construct homemade electrochemical flow cells have been attracted to work in the area. This overview aims to show both trends and future potential for the development of new methods useful for modern electroanalysis and/or portable applications.

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Recent developments, characteristics and potential applications of screen-printed electrodes in pharmaceutical and biological analysis

Cited by 209 publications

References 118 publications

Wireless Point-of-Care Platform With Screen-Printed Sensors for Biomarkers Detection

Wireless Point-of-Care Platform With Screen-Printed Sensors for Biomarkers Detection

Use of Redox Probes for Characterization of Layer-by-Layer Gold Nanoparticle-Modified Screen-Printed Carbon Electrodes

An Overview of Recent Electroanalytical Applications Utilizing Screen‐Printed Electrodes Within Flow Systems

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