Recent Developments and Biological Activities of N-Substituted Carbazole Derivatives: A Review

Bashir, Maryam; Bano, Afifa; Ijaz, Abdul Subhan; Chaudhary, Bashir A.

doi:10.3390/molecules200813496

Cited by 162 publications

(97 citation statements)

References 66 publications

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“…Carbazole (C 12 H 9 N), also named dibenzopyrrole or diphenylenimine, is an N-containig heterocyclic compound discovered by Graebe and Glaser in 1872 [ 42 ]. Its structure consists of two benzene ring fused on either side of a central pyrrole ring ( Figure 2 ) [ 43 ]. Carbazole represents an important class of heterocycles with several advantages.…”

Section: Introductionmentioning

confidence: 99%

Polycarbazole and Its Derivatives: Synthesis and Applications. A Review of the Last 10 Years

et al. 2020

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Polycarbazole and its derivatives have been extensively used for the last three decades, although the interest in these materials briefly decreased. However, the increasing demand for conductive polymers for several applications such as light emitting diodes (OLEDs), capacitators or memory devices, among others, has renewed the interest in carbazole-based materials. In this review, the synthetic routes used for the development of carbazole-based polymers have been summarized, reviewing the main synthetic methodologies, namely chemical and electrochemical polymerization. In addition, the applications reported in the last decade for carbazole derivatives are analysed. The emergence of flexible and wearable electronic devices as a part of the internet of the things could be an important driving force to renew the interest on carbazole-based materials, being conductive polymers capable to respond adequately to requirement of these devices.

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Section: Introductionmentioning

confidence: 99%

Polycarbazole and Its Derivatives: Synthesis and Applications. A Review of the Last 10 Years

et al. 2020

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“…The structure of MDMB-CHMCZCA, a semi-systematic name for m ethyl d i m ethyl b utanoate- c yclo h exyl m ethyl c arba z ole c arbox a mide, is related to the structure of MDMB-CHMICA, but contains an N -alkylated carbazole instead of an indole core. Carbazoles are the core structures of an emerging group of cannabimimetics [11–12]. Several N -alkylated carbazole-3-carboxamides were patented by Diaz, Diaz, and Petrov in 2012 as tricyclic cannabinoid receptor modulators, explored against neuropathic pain [13].…”

Section: Introductionmentioning

confidence: 99%

Characterization of the synthetic cannabinoid MDMB-CHMCZCA

Weber¹,

Pusch²,

Schollmeyer³

et al. 2016

Beilstein J. Org. Chem.

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The synthetic cannabinoid MDMB-CHMCZCA was characterized by various spectroscopic techniques including NMR spectroscopy and tandem mass spectrometry. The synthetic sample was found to be of S-configuration by VCD spectroscopy and comparison of the data with DFT calculations, while ECD spectroscopy was found to be inconclusive in this case. The enantiomeric purity of samples from test purchases and police seizures was assessed by a self-developed chiral HPLC method.

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“…69 Carprofen is a carbazole-based drug used in the treatment of pain in veterinary science. 70 However, more recently, the visible-light-mediated synthesis of carbazoles with a Cu-based sensitizer and the use of continuous-flow conditions resulted in an approximately 12-fold decrease in reaction time (Scheme 12a). 71 In an alternative approach to carbazoles, aryl azides were used as a photochemical reagent allowing access to more complex heterocycles under UV-LED irradiation in a continuous flow reactor.…”

Section: Photoredox Catalysis Reactionmentioning

confidence: 99%

Light on the Horizon: Current Research and Future Perspectives in Flow Photochemistry

Politano

Oksdath‐Mansilla

2018

Org. Process Res. Dev.

147

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The research area of synthetic organic photochemistry is a powerful tool for creating both natural products and molecules with high structural complexity, in a simple way and under mild conditions. However, because of the challenges in scaling-up, it has been difficult to apply a photochemical reaction in an industrial process. Flow chemistry provides an opportunity for better control over the conditions of the reaction and, additionally, improved reaction selectivity and enhanced reproducibility. Taking into account that significant interest has focused on the use of flow photochemistry as a method for the synthesis of heterocycles and its applications in target-oriented synthesis over the last few years, the aim of this review is to highlight the recent efforts to apply flow photochemistry methodology to diverse reactions as a greener and more scalable process for the pharmaceutical and fine chemical industries. Additionally, the review highlights future perspectives in the development of scale-up strategies, combining photochemical reactions in the continuous flow multistep synthesis of organic molecules, being of interest for scientists and engineers alike.

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Recent Developments and Biological Activities of N-Substituted Carbazole Derivatives: A Review

Cited by 162 publications

References 66 publications

Polycarbazole and Its Derivatives: Synthesis and Applications. A Review of the Last 10 Years

Polycarbazole and Its Derivatives: Synthesis and Applications. A Review of the Last 10 Years

Characterization of the synthetic cannabinoid MDMB-CHMCZCA

Light on the Horizon: Current Research and Future Perspectives in Flow Photochemistry

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