Recent Development of Nano-Carbon Material in Pharmaceutical Application: A Review

Jiwanti, Prastika Krisma; Wardhana, Brasstira Yuva; Sutanto, Laurencia G.; Dewi, Diva Meisya Maulina; Putri, Ilmanda Zalzabhila Danistya; Savitri, Ilmi Nur Indira

doi:10.3390/molecules27217578

Cited by 17 publications

(15 citation statements)

References 234 publications

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“…Given hydrophobins are known to reverse surface wettability of both hydrophobic and hydrophilic substrates, we studied whether EAS Δ15 can interact with surface functionalized NDs (SF-NDs) which are much more hydrophilic than HPHT NDs. While hydrophobic NDs of HPHT origin are still used in many applications, surface functionalized hydrophilic NDs have been produced more recently for a wider range of applications. , The SF-NDs used in this study have been treated with strong acids and are further air-oxidized, which introduces changes to their surface charge due to the addition of terminal carboxylic acid groups and improves their colloidal stability. Here, SF-NDs from 10 to 15 nm in diameter which are most similar in size to the Hb-NDs were tested.…”

Section: Resultsmentioning

confidence: 99%

Surface-Induced Hydrophobin Assemblies with Versatile Properties and Distinct Underlying Structures

Siddiquee,

Lo,

Johnston

et al. 2023

Biomacromolecules

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Hydrophobins are remarkable proteins due to their ability to self-assemble into amphipathic coatings that reverse surface wettability. Here, the versatility of the Class I hydrophobins EAS Δ15 and DewY in diverse nanosuspension and coating applications is demonstrated. The hydrophobins are shown to coat or emulsify a range of substrates including oil, hydrophobic drugs, and nanodiamonds and alter their solution and surface behavior. Surprisingly, while the coatings confer new properties, only a subset is found to be resistant to hot detergent treatment, a feature previously thought to be characteristic of the functional amyloid form of Class I hydrophobins. These results demonstrate that substrate surface properties can influence the molecular structures and physiochemical properties of hydrophobin and possibly other functional amyloids. Functional amyloid assembly with different substrates and conditions may be analogous to the propagation of different polymorphs of disease-associated amyloid fibrils with distinct structures, stability, and clinical phenotypes. Given that amyloid formation is not required for Class I hydrophobins to serve diverse applications, our findings open up new opportunities for their use in applications requiring a range of chemical and physical properties. In hydrophobin nanotechnological applications where high stability of assemblies is required, simultaneous structural and functional characterization should be carried out. Finally, while results in this study pertain to synthetic substrates, they raise the possibility that at least some members of the pseudo-Class I and Class III hydrophobins, reported to form assemblies with noncanonical properties, may be Class I hydrophobins adopting alternative structures in response to environmental cues.

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Section: Resultsmentioning

confidence: 99%

Surface-Induced Hydrophobin Assemblies with Versatile Properties and Distinct Underlying Structures

Siddiquee,

Lo,

Johnston

et al. 2023

Biomacromolecules

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“…Notably, biomedical applications such as immuno-oncology need total biocompatibility in order to avoid undesirable immune system responses [ 15 ]. The functionalization of CNMs has the potential to change their physical and chemical characteristics, as well as increase their therapeutic efficacy and bioactivity, reduce the immune response, and enable targeted drug delivery [ 16 ]. This implies that the ease of chemically modifying CNMs provide another layer of capacity to create new systems that can be adapted for specific interventions in immuno-oncology.…”

Section: Functionalization Of Cnms In Targeting Cancermentioning

confidence: 99%

Carbon Nanomaterials: Emerging Roles in Immuno-Oncology

Patrick

Akhtar

Kousar

et al. 2023

IJMS

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Cancer immunotherapy has made breakthrough progress in cancer treatment. However, only a subset of patients benefits from immunotherapy. Given their unique structure, composition, and interactions with the immune system, carbon nanomaterials have recently attracted tremendous interest in their roles as modulators of antitumor immunity. Here, we focused on the latest advances in the immunological effects of carbon nanomaterials. We also reviewed the current preclinical applications of these materials in cancer therapy. Finally, we discussed the challenges to be overcome before the full potential of carbon nanomaterials can be utilized in cancer therapies to ultimately improve patient outcomes.

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“…GO exhibits a photothermal effect upon 808 nm NIR radiation, FA is a targeting agent, and this carrier can exert a chemophotodynamic effect in OS 101 . Further innovation based on graphene nanomaterials resulted in graphene‐related polymers, which have the advantages of both graphene and polymers 102 . Such nanocarriers often have multiple functional groups, such as hydroxyl (–OH), carboxylic acid (–COOH) and amine (–NH 2 ), which further improve the loading efficiency (LE) of the carrier for chemotherapeutic drugs 103 .…”

Section: Organic Nanomaterialsmentioning

confidence: 99%

Research Progress of Nanomaterials in Chemotherapy of Osteosarcoma

Cai

Chang

et al. 2023

Orthopaedic Surgery

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Osteosarcoma (OS) is a common malignant bone tumor that occurs mostly in children and adolescents. At present, surgery after chemotherapy or postoperative adjuvant chemotherapy is the main treatment plan. However, the efficacy of chemotherapeutic drugs is limited by the occurrence of chemotherapeutic resistance, toxicity to normal cells, poor pharmacokinetic performance, and drug delivery failure. The delivery of chemotherapy drugs to the bone to treat OS may fail for a variety of reasons, such as a lack of selectivity for OS cells, initial sudden release, short‐term release, and the presence of biological barriers (such as the blood‐bone marrow barrier). Nanomaterials are new materials with at least one dimension on the nanometer scale (1–100 nm) in three‐dimensional space. These materials have the ability to penetrate biological barriers and can accumulate preferentially in tumor cells. Studies have shown that the effective combination of nanomaterials and traditional chemotherapy can significantly improve the therapeutic effect. Therefore, this article reviews the latest research progress on the use of nanomaterials in OS chemotherapy.

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Recent Development of Nano-Carbon Material in Pharmaceutical Application: A Review

Cited by 17 publications

References 234 publications

Surface-Induced Hydrophobin Assemblies with Versatile Properties and Distinct Underlying Structures

Surface-Induced Hydrophobin Assemblies with Versatile Properties and Distinct Underlying Structures

Carbon Nanomaterials: Emerging Roles in Immuno-Oncology

Research Progress of Nanomaterials in Chemotherapy of Osteosarcoma

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