Recent Development of Metal Nanoparticles for Angiogenesis Study and Their Therapeutic Applications

Barui, Ayan Kumar; Nethi, Susheel Kumar; Haque, Shagufta; Basuthakur, Papia; Patra, Chitta Ranjan

doi:10.1021/acsabm.9b00587

Cited by 36 publications

(25 citation statements)

References 180 publications

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“…A wide range of metal-based nanoparticles have been widely used as angiogenic treatments for wound healing and skin regeneration. Zinc oxide nanoparticles (ZnO-NPs) have been shown to induce endothelial cell migration and enhance blood vessel formation by producing nitric oxide (NO) through the MAPK/Akt/eNOS pathway [105]. The incorporation of ZnO-NPs in scaffolds is a promising approach for skin tissue engineering applications.…”

Section: Metal Nanoparticlesmentioning

confidence: 99%

Nanocomposite scaffolds for accelerating chronic wound healing by enhancing angiogenesis

et al. 2021

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Skin is the body’s first barrier against external pathogens that maintains the homeostasis of the body. Any serious damage to the skin could have an impact on human health and quality of life. Tissue engineering aims to improve the quality of damaged tissue regeneration. One of the most effective treatments for skin tissue regeneration is to improve angiogenesis during the healing period. Over the last decade, there has been an impressive growth of new potential applications for nanobiomaterials in tissue engineering. Various approaches have been developed to improve the rate and quality of the healing process using angiogenic nanomaterials. In this review, we focused on molecular mechanisms and key factors in angiogenesis, the role of nanobiomaterials in angiogenesis, and scaffold-based tissue engineering approaches for accelerated wound healing based on improved angiogenesis.

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Section: Metal Nanoparticlesmentioning

confidence: 99%

Nanocomposite scaffolds for accelerating chronic wound healing by enhancing angiogenesis

et al. 2021

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“… ( a ) Overview of the use of metal oxides in nanoparticulate form for wound healing related processes [ 59 , 60 , 72 , 73 , 74 , 75 , 76 ]. ( b ) Different possible architectures and structures of metal oxide nanohybrids.…”

Section: Figurementioning

confidence: 99%

Uniting Drug and Delivery: Metal Oxide Hybrid Nanotherapeutics for Skin Wound Care

2020

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Wound care and soft tissue repair have been a major human concern for millennia. Despite considerable advancements in standards of living and medical abilities, difficult-to-heal wounds remain a major burden for patients, clinicians and the healthcare system alike. Due to an aging population, the rise in chronic diseases such as vascular disease and diabetes, and the increased incidence of antibiotic resistance, the problem is set to worsen. The global wound care market is constantly evolving and expanding, and has yielded a plethora of potential solutions to treat poorly healing wounds. In ancient times, before such a market existed, metals and their ions were frequently used in wound care. In combination with plant extracts, they were used to accelerate the healing of burns, cuts and combat wounds. With the rise of organic chemistry and small molecule drugs and ointments, researchers lost their interest in inorganic materials. Only recently, the advent of nano-engineering has given us a toolbox to develop inorganic materials on a length-scale that is relevant to wound healing processes. The robustness of synthesis, as well as the stability and versatility of inorganic nanotherapeutics gives them potential advantages over small molecule drugs. Both bottom-up and top-down approaches have yielded functional inorganic nanomaterials, some of which unite the wound healing properties of two or more materials. Furthermore, these nanomaterials do not only serve as the active agent, but also as the delivery vehicle, and sometimes as a scaffold. This review article provides an overview of inorganic hybrid nanotherapeutics with promising properties for the wound care field. These therapeutics include combinations of different metals, metal oxides and metal ions. Their production, mechanism of action and applicability will be discussed in comparison to conventional wound healing products.

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“…Polymer-functionalized inorganic nanomaterials consist of an inorganic core made up of atoms with numbers ranging from several hundreds to a few thousands and a polymer outer layer. This fascinating structure imparts metallic NPs with designable physicochemical properties, including solubility, surface potential, surface functional groups, and surface chemical affinity [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

“…Capping polymers with strong intra/intermolecular bonding interactions should be avoided because these forces increase the viscosity of the colloidal solution system and decrease the degree of freedom of NPs. Finally, an ideal capping polymer should possess a strong surface potential and as many unbonded terminal functional groups as possible to protect the NPs from aggregation and endow them with chemical affinity to target polymers [15,17,18]. Therefore, micromolecules and linear polymers are unsatisfactory candidates for the capping of metal NPs.…”

Section: Introductionmentioning

confidence: 99%

General Strategy to Prepare Single-Layered Ag–Au–Pt Nanocrystal Ternary-Coated Biomass Textiles through Polymer-Driven Self-Assembly

Gao

Feng

et al. 2020

Nanomaterials

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Current metal nanomaterials for developing nanofunctional textiles are mostly based on metal nanoparticles (NPs) that show aqueous instability, a tendency to aggregate, and low chemical affinity to biomass textiles, leading to low nano-metal uptake during finishing, significant declines in function, and nano-pollution. Herein, we demonstrate a strategy to transform metal (Ag, Au, and Pt) NPs into homogenous hyperbranched poly(amide-amine) (HBPAA)-encapsulated NPs showing high water solubility, oxidative resistance, and affinity to biomass materials upon surface capping with HBPAA. The proposed method represents a universal, simple, clean, and efficient self-assembly technology to produce monolayered Ag–Au–Pt ternary-coated biomass textiles. The combination of Ag, Au, and Pt NPs yields a positive potential of approximately +37.12 mV depending on the metal concentration and could simultaneously self-assemble onto natural fibers, including cotton, silk, and wool, through the one-step impregnation of textiles. Increasing the temperature and concentration of the mixture favors the self-assembly process. A mixture of 30–110 mg/L Ag, Au, and Pt NPs could nearly completely anchor onto cotton, silk, and wool textiles after impregnation at 100 °C for 1 h without chemical assistance, thereby indicating the possibility of clean production. As-prepared functional cotton, silk, and wool possessed similarly high antibacterial activities, and a mixture containing over 1500 mg/g NPs inhibited 99% of the Escherichia coli and Staphylococcus aureus in the sample textiles. The developed coating technology is simple, clean, controllable, and broadly applicable; thus, it could be potentially applied in functional textiles.

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Recent Development of Metal Nanoparticles for Angiogenesis Study and Their Therapeutic Applications

Cited by 36 publications

References 180 publications

Nanocomposite scaffolds for accelerating chronic wound healing by enhancing angiogenesis

Nanocomposite scaffolds for accelerating chronic wound healing by enhancing angiogenesis

Uniting Drug and Delivery: Metal Oxide Hybrid Nanotherapeutics for Skin Wound Care

General Strategy to Prepare Single-Layered Ag–Au–Pt Nanocrystal Ternary-Coated Biomass Textiles through Polymer-Driven Self-Assembly

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