Recent Development of Inorganic Nanoparticles for Biomedical Imaging

Abstract

Inorganic nanoparticle-based biomedical imaging probes have been studied extensively as a potential alternative to conventional molecular imaging probes. Not only can they provide better imaging performance but they can also offer greater versatility of multimodal, stimuli-responsive, and targeted imaging. However, inorganic nanoparticle-based probes are still far from practical use in clinics due to safety concerns and less-optimized efficiency. In this context, it would be valuable to look over the underlying issues. This outlook highlights the recent advances in the development of inorganic nanoparticle-based probes for MRI, CT, and anti-Stokes shift-based optical imaging. Various issues and possibilities regarding the construction of imaging probes are discussed, and future research directions are suggested.

Noninvasive and real-time pharmacokinetics imaging of polymeric nanoagents in the thoracoepigastric vein networks of living mice

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“…These bioimaging modalities, however, are limited in capturing enough dynamic details of blood vasculatures, owing to insufficient spatiotemporal resolutions. [44][45][46][47] For instance, the recently developed microultrasonography offers a temporal resolution up to a millisecond; however, the spatial resolution deteriorates considerably with increasing imaging depth. 48 The near-infrared OCT, featuring label-free, subcellular spatial resolution, millimeter penetration depth, and wide field-of-view (FOV), has been clinically adopted in ophthalmology, cardiology, and gastrointestinal cancer screening.…”

Tuning the Bandgap Character of Quantum‐Confined Si–Sn Alloyed Nanocrystals

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Fabrication of Mn2+-Doped Hollow Mesoporous Aluminosilica Nanoparticles for Magnetic Resonance Imaging and Drug Delivery for Therapy of Colorectal Cancer

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