Recent development of egg protein fractions and individual proteins as encapsulant materials for delivery of bioactives

Zhang, Yue; Guo, Yunsi; Liu, Feng; Luo, Yangchao

doi:10.1016/j.foodchem.2022.134353

Cited by 25 publications

(7 citation statements)

References 120 publications

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“…These properties make albumin-based hydrogels promising for applications in the biomedical field. To date, due to their excellent properties, albumin-based hydrogels have been used in a wide range of applications including drug delivery, tissue regeneration engineering, diagnostics, cell transplantation and more ( Chander et al, 2021 ; Mahdipour and Mequanint, 2022 ; Zhang et al, 2023 ). In this section, we summarize in detail the three main properties of albumin-based hydrogels to increase the knowledge of their advantageous properties.…”

Section: Properties and Preparation Methods Of Albumin-based Hydrogelsmentioning

confidence: 99%

Research progress on albumin-based hydrogels: Properties, preparation methods, types and its application for antitumor-drug delivery and tissue engineering

Meng

Zhu

Deng

et al. 2023

Front. Bioeng. Biotechnol.

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Albumin is derived from blood plasma and is the most abundant protein in blood plasma, which has good mechanical properties, biocompatibility and degradability, so albumin is an ideal biomaterial for biomedical applications, and drug-carriers based on albumin can better reduce the cytotoxicity of drug. Currently, there are numerous reviews summarizing the research progress on drug-loaded albumin molecules or nanoparticles. In comparison, the study of albumin-based hydrogels is a relatively small area of research, and few articles have systematically summarized the research progress of albumin-based hydrogels, especially for drug delivery and tissue engineering. Thus, this review summarizes the functional features and preparation methods of albumin-based hydrogels, different types of albumin-based hydrogels and their applications in antitumor drugs, tissue regeneration engineering, etc. Also, potential directions for future research on albumin-based hydrogels are discussed.

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Section: Properties and Preparation Methods Of Albumin-based Hydrogelsmentioning

confidence: 99%

Research progress on albumin-based hydrogels: Properties, preparation methods, types and its application for antitumor-drug delivery and tissue engineering

Meng

Zhu

Deng

et al. 2023

Front. Bioeng. Biotechnol.

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“…This study demonstrates the potential of amphiphilic biodynamers as promising nanoparticles for protein delivery while comparing two different formulation methods. Utilizing the easy controllability of biodynamers in charge and amphiphilicity, PNCs were first used to load oppositely charged protein cargos, OVA, 34 IH, 35 and GLP-1 via electrostatic interactions. 36 Secondly, the same biodynamers were used to form the lipophilic compartment of the DE-NPs.…”

Section: Introductionmentioning

confidence: 99%

Biodynamer Nano-Complexes and -Emulsions for Peptide and Protein Drug Delivery

Liu,

Hamm,

Eichinger

et al. 2024

IJN

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Background Therapeutic proteins and peptides offer great advantages compared to traditional synthetic molecular drugs. However, stable protein loading and precise control of protein release pose significant challenges due to the extensive range of physicochemical properties inherent to proteins. The development of a comprehensive protein delivery strategy becomes imperative accounting for the diverse nature of therapeutic proteins. Methods Biodynamers are amphiphilic proteoid dynamic polymers consisting of amino acid derivatives connected through pH-responsive dynamic covalent chemistry. Taking advantage of the amphiphilic nature of the biodynamers, PNCs and DEs were possible to be prepared and investigated to compare the delivery efficiency in drug loading, stability, and cell uptake. Results As a result, the optimized PNCs showed 3-fold encapsulation (<90%) and 5-fold loading capacity (30%) compared to DE-NPs. PNCs enhanced the delivery efficiency into the cells but aggregated easily on the cell membrane due to the limited stability. Although DE-NPs were limited in loading capacity compared to PNCs, they exhibit superior adaptability in stability and capacity for delivering a wider range of proteins compared to PNCs. Conclusion Our study highlights the potential of formulating both PNCs and DE-NPs using the same biodynamers, providing a comparative view on protein delivery efficacy using formulation methods.

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“…A practical and inexpensive stabilizing agent for NMCs is ovalbumin [21][22][23]. In this direction, Synch et al [24] measured the fluorescence emitted by silver clusters synthesized in, among other types of proteins, ovalbumin.…”

Section: Introductionmentioning

confidence: 99%

Structural and optical properties of the Ag _n –tyrosine complexes ( n = 3−12): a density functional theory study

Balan,

Morato-Márquez,

Torres-Torres

et al. 2023

R. Soc. open sci.

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We study the optical properties of Ag n ( n = 3–12) neutral clusters and their coordination with a tyrosine (Tyr) molecule. A global search strategy coupled with density functional theory (DFT) computations explored the potential energy surface. Adsorption energy calculations predicted that Tyr coordination stabilizes the metal clusters, favouring the Ag n −Tyr complexes with an even number of silver atoms. For the Ag n low-lying isomers, the general shape and the major transitions of the calculated time dependent-DFT (TD-DFT) absorption spectra align with those of previous reports measured in an argon environment. We use the analysis of non-covalent interactions to identify the specific interactions between each silver cluster and functional groups of Tyr. The TD-DFT absorption spectra for the Ag n −Tyr complexes showed that Tyr significantly modifies the optical properties of the coordinated silver clusters and affects the smaller systems to a greater extent. The optical absorption results of the bare Ag n clusters and the Ag n −Tyr complexes are compared and discussed in detail.

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Recent development of egg protein fractions and individual proteins as encapsulant materials for delivery of bioactives

Cited by 25 publications

References 120 publications

Research progress on albumin-based hydrogels: Properties, preparation methods, types and its application for antitumor-drug delivery and tissue engineering

Research progress on albumin-based hydrogels: Properties, preparation methods, types and its application for antitumor-drug delivery and tissue engineering

Biodynamer Nano-Complexes and -Emulsions for Peptide and Protein Drug Delivery

Structural and optical properties of the Ag _n –tyrosine complexes ( n = 3−12): a density functional theory study

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Recent development of egg protein fractions and individual proteins as encapsulant materials for delivery of bioactives

Cited by 25 publications

References 120 publications

Research progress on albumin-based hydrogels: Properties, preparation methods, types and its application for antitumor-drug delivery and tissue engineering

Research progress on albumin-based hydrogels: Properties, preparation methods, types and its application for antitumor-drug delivery and tissue engineering

Biodynamer Nano-Complexes and -Emulsions for Peptide and Protein Drug Delivery

Structural and optical properties of the Ag n –tyrosine complexes ( n = 3−12): a density functional theory study

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Product

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Structural and optical properties of the Ag _n –tyrosine complexes ( n = 3−12): a density functional theory study