Research progress on albumin-based hydrogels: Properties, preparation methods, types and its application for antitumor-drug delivery and tissue engineering

Meng, Run; Zhu, Huimin; Deng, Peiying; Li, Minghui; Ji, Qingzhi; He, Hao; Jin, Liang; Wang, Bochu

doi:10.3389/fbioe.2023.1137145

Cited by 6 publications

(4 citation statements)

References 212 publications

(219 reference statements)

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“…Effects of Formulation and Process Factors on DTX-BSA-NPs Prepared by Thermal-Driven Self-Assembly BSA NPs have been extensively investigated for the delivery of anticancer drugs due to their excellent biocompatibility, nontoxicity, non-immunogenicity, biodegradability, and ability to target tumor tissues through specific receptor interactions. 45,46 As a novel organic solvent-free approach to produce albumin NPs, 47 thermal-driven self-assembly was used in the current study to prepare DTX-BSA-NPs.…”

Section: Resultsmentioning

confidence: 99%

Crafting Docetaxel-Loaded Albumin Nanoparticles Through a Novel Thermal-Driven Self-Assembly/Microfluidic Combination Technology: Formulation, Process Optimization, Stability, and Bioavailability

Du,

Shi,

Jiang

et al. 2024

IJN

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Background The commercial docetaxel (DTX) formulation causes severe side effects due to polysorbate 80 and ethanol. Novel surfactant-free nanoparticle (NP) systems are needed to improve bioavailability and reduce side effects. However, controlling the particle size and stability of NPs and improving the batch-to-batch variation are the major challenges. Methods DTX-loaded bovine serum albumin nanoparticles (DTX-BSA-NPs) were prepared by a novel thermal-driven self-assembly/microfluidic technology. Single-factor analysis and orthogonal test were conducted to obtain the optimal formulation of DTX-BSA-NPs in terms of particle size, encapsulation efficiency (EE), and drug loading (DL). The effects of oil/water flow rate and pump pressure on the particle size, EE, and DL were investigated to optimize the preparation process of DTX-BSA-NPs. The drug release, physicochemical properties, stability, and pharmacokinetics of NPs were evaluated. Results The optimized DTX-BSA-NPs were uniform, with a particle size of 118.30 nm, EE of 89.04%, and DL of 8.27%. They showed a sustained release of 70% over 96 hours and an increased stability. There were some interactions between the drug and excipients in DTX-BSA-NPs. The half-life, mean residence time, and area under the curve (AUC) of DTX-BSA-NPs increased, but plasma clearance decreased when compared with DTX. Conclusion The thermal-driven self-assembly/microfluidic combination method effectively produces BSA-based NPs that improve the bioavailability and stability of DTX, offering a promising alternative to traditional formulations.

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Section: Resultsmentioning

confidence: 99%

Crafting Docetaxel-Loaded Albumin Nanoparticles Through a Novel Thermal-Driven Self-Assembly/Microfluidic Combination Technology: Formulation, Process Optimization, Stability, and Bioavailability

Du,

Shi,

Jiang

et al. 2024

IJN

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“…The degradation rate is influenced by factors such as the composition of the hydrogel, cross-linking density, the presence of enzymes or catalysts, and the physicochemical environment. As the hydrogel degrades, the therapeutic agents are gradually released into the surrounding medium [124,125].…”

Section: Biological and Pharmacological Effects Of Aloe Veramentioning

confidence: 99%

Aloe vera-Based Hydrogels for Wound Healing: Properties and Therapeutic Effects

Chelu

Musuc

Popa

et al. 2023

Gels

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Aloe vera-based hydrogels have emerged as promising platforms for the delivery of therapeutic agents in wound dressings due to their biocompatibility and unique wound-healing properties. The present study provides a comprehensive overview of recent advances in the application of Aloe vera-based hydrogels for wound healing. The synthesis methods, structural characteristics, and properties of Aloe vera-based hydrogels are discussed. Mechanisms of therapeutic agents released from Aloe vera-based hydrogels, including diffusion, swelling, and degradation, are also analyzed. In addition, the therapeutic effects of Aloe vera-based hydrogels on wound healing, as well as the reduction of inflammation, antimicrobial activity, and tissue regeneration, are highlighted. The incorporation of various therapeutic agents, such as antimicrobial and anti-inflammatory ones, into Aloe vera-based hydrogels is reviewed in detail. Furthermore, challenges and future prospects of Aloe vera-based hydrogels for wound dressing applications are considered. This review provides valuable information on the current status of Aloe vera-based hydrogels for the delivery of therapeutic agents in wound dressings and highlights their potential to improve wound healing outcomes.

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“…Modifying nanoparticle size and shape, utilizing enzyme-inhibiting coatings, and employing cryopreservation and lyophilization address issues related to immune evasion, enzymatic degradation, and structural integrity [234,235]. Implementations of antioxidants, hydrogel encapsulation, and optimized buffer solutions offer protection against various stresses and maintain albumin structure [236,237]. Molecular imprinting and stimuli-responsive elements have also been utilized for improved drug loading and controlled delivery [238][239][240][241].…”

Section: Stability and Longevitymentioning

confidence: 99%

Translational Challenges and Prospective Solutions in the Implementation of Biomimetic Delivery Systems

Wang,

et al. 2023

Pharmaceutics

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Biomimetic delivery systems (BDSs), inspired by the intricate designs of biological systems, have emerged as a groundbreaking paradigm in nanomedicine, offering unparalleled advantages in therapeutic delivery. These systems, encompassing platforms such as liposomes, protein-based nanoparticles, extracellular vesicles, and polysaccharides, are lauded for their targeted delivery, minimized side effects, and enhanced therapeutic outcomes. However, the translation of BDSs from research settings to clinical applications is fraught with challenges, including reproducibility concerns, physiological stability, and rigorous efficacy and safety evaluations. Furthermore, the innovative nature of BDSs demands the reevaluation and evolution of existing regulatory and ethical frameworks. This review provides an overview of BDSs and delves into the multifaceted translational challenges and present emerging solutions, underscored by real-world case studies. Emphasizing the potential of BDSs to redefine healthcare, we advocate for sustained interdisciplinary collaboration and research. As our understanding of biological systems deepens, the future of BDSs in clinical translation appears promising, with a focus on personalized medicine and refined patient-specific delivery systems.

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Research progress on albumin-based hydrogels: Properties, preparation methods, types and its application for antitumor-drug delivery and tissue engineering

Cited by 6 publications

References 212 publications

Crafting Docetaxel-Loaded Albumin Nanoparticles Through a Novel Thermal-Driven Self-Assembly/Microfluidic Combination Technology: Formulation, Process Optimization, Stability, and Bioavailability

Crafting Docetaxel-Loaded Albumin Nanoparticles Through a Novel Thermal-Driven Self-Assembly/Microfluidic Combination Technology: Formulation, Process Optimization, Stability, and Bioavailability

Aloe vera-Based Hydrogels for Wound Healing: Properties and Therapeutic Effects

Translational Challenges and Prospective Solutions in the Implementation of Biomimetic Delivery Systems

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