Recent considerations in the use of recombinant interferon gamma for biological therapy of atopic dermatitis

Abstract

Introduction Atopic dermatitis (AD) is the most common inflammatory skin disease in the general population. There are different endophenotypes of AD that likely have a unique immune and molecular basis, such as those who are predisposed to eczema herpeticum, or Staphylococcus aureus infections. Areas Covered In this review, we highlight the endophenotypes of AD where reduced interferon gamma expression may be playing a role. Additionally, we review the potential role of recombinant interferon gamma therapy in the treatment of atopic dermatitis and the particular phenotypes that may benefit from this treatment. Expert Opinion Recombinant interferon gamma treatment will likely benefit the pediatric population with AD, as well as those with susceptibilities for skin infections. Future studies are needed to elucidate whether IFN-γ may reduce the prevalence of skin infection in AD.

Psoriasis and Atopic Dermatitis

“…Treatment with recombinant interferon-γ is well-tolerated in patients with severe, unremitting atopic dermatitis, with clinical improvement reflecting decreases in absolute white blood cell and eosinophil counts [ 68 ]. This type of therapy shows particular promise among pediatric patients with atopic dermatitis, although further studies are needed to determine the effects of interferon-γ on the prevalence of skin infection [ 69 ].…”

The importance of cytokines for the atopic dermatitis pathogenesis

“…ИФН-γ играет центральную роль в дифференцировке Th1-клеток [32]. ИФН-γ способствует созреванию/дифференцировке кератиноцитов, усиливает синтез церамидов, что содействует восстановлению кожного барьера [33,34]. Снижение продукции ИФН-γ связано с колонизацией кожи S.aureus [34].…”

Atopic Dermatitis: Early Treatment in Children

“…67% of children ages 3 to 20 reported greater than 50% improvement, compared to 56% of adults ages 21–40 and 44% of adults ages 41–65 [101]. Side-effects included flu-like symptoms, transient transaminase elevation, and granulocyte suppression [102]. …”