Recent clinical evidence in the herbal therapy of neonatal jaundice in Iran: A review

Khedmat, Leila; Mojtahedi, Sayed Yousef; Moienafshar, Atousa

doi:10.1016/j.hermed.2021.100457

Cited by 4 publications

(3 citation statements)

References 32 publications

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“…Traditional herbal medicines might play a significant role in decreasing the serum bilirubin level by increasing defecation and interrupting the enterohepatic cycle (38). Cotoneaster (the purgative manna), pomegranate paste, jujube, barley flour, Alhagi maurorum Medik, Fumaria officinalis, and chicory aroma are the famous herbal agents for this issue (39,40). Pojark manna (Shir-e-Khesht) is popular in Persian medicine.…”

Section: Herbal Agents For Treatment Of Neonatal Jaundicementioning

confidence: 99%

Recent Advances in Adjuvant Pharmacotherapy for Neonatal Indirect Hyperbilirubinemia: A Narrative Review

Nouri

Zarkesh

2023

J Compr Ped

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Context: Hyperbilirubinemia is a common cause for diagnostic work-up and therapeutic intervention in neonates and needs a convenient, quick, and safe treatment modality. Phototherapy is the most common treatment for neonatal jaundice; however, complementary treatment is still needed. Despite the identification of the enzymatic pathways of bilirubin catabolism, few pharmacological interventions have been found to be effective in reducing bilirubin, along with traditional phototherapy. This review was conducted to evaluate recent pharmacotherapies as adjuvants to phototherapy for the treatment of neonatal indirect hyperbilirubinemia (IHB). Evidence Acquisition: This study was carried out through a literature search with the keywords of Infant, Newborn, and Indirect Hyperbilirubinemia, combined with Drug Therapy, in PubMed, Scopus, International Statistical Institute, Web of Science, Cochrane, and Embase databases. This study included relevant articles (i.e., randomized controlled trials, observational studies, guidelines, and reviews) written in English and published between 2012 - 2022. Results: This narrative review first assessed the relevant articles to define IHB and its etiology. Then, the efficacy and side effects of recent pharmacologic agents as adjuvants to phototherapy were discussed. Additionally, this study reviewed the efficacy and safety of drugs prescribed to neonates to prevent jaundice. Conclusions: The best drug for adjuvant pharmacotherapy, in addition to phototherapy, for neonatal jaundice has not still been identified. The use of probiotics, prebiotics, synbiotics, and ursodeoxycholic acid (UDCA) in adjuvant to phototherapy has been recently increasing, and beneficial results were observed in most studies. The use of agar, charcoal, fibrate, and phenobarbital had a minor therapeutic role in recent years. There were conflicting results about the efficacy of herbal agents in neonatal jaundice. The use of intravenous immunoglobulin (IVIG), metalloporphyrin, and albumin is also limited to severe or immune-related IHB cases. The prescription of the aforementioned drugs sometimes had different results. Therefore, further research in this regard is necessary.

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Section: Herbal Agents For Treatment Of Neonatal Jaundicementioning

confidence: 99%

Recent Advances in Adjuvant Pharmacotherapy for Neonatal Indirect Hyperbilirubinemia: A Narrative Review

Nouri

Zarkesh

2023

J Compr Ped

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“…Neonatal hepatic uptake, conjugation, and biliary excretion of bilirubin are still maturing to reach full function, resulting in a physiological rise in unconjugated bilirubin in the first 2 weeks of life 15 . The need for age‐specific interpretation of direct and total bilirubin in the early postnatal period is well appreciated given the importance of identifying hyperbilirubinemia, jaundice, and resultant brain injury risk 16 . A new hour‐specific serum bilirubin nomogram for neonates ≥35 weeks of gestation was recently developed to assist in interpretation but does not cover the first few months of life and is mainly based on a Caucasian population.…”

Section: Introductionmentioning

confidence: 99%

“… 15 The need for age‐specific interpretation of direct and total bilirubin in the early postnatal period is well appreciated given the importance of identifying hyperbilirubinemia, jaundice, and resultant brain injury risk. 16 A new hour‐specific serum bilirubin nomogram for neonates ≥35 weeks of gestation was recently developed to assist in interpretation but does not cover the first few months of life and is mainly based on a Caucasian population. Studies have also shown that liver enzymes, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) are influenced by early neonatal physiology and change dramatically within the first few months.…”

Section: Introductionmentioning

confidence: 99%

Age‐specific reference intervals for liver function tests in healthy neonates, infants, and young children in Iran

Badakhshan,

Ghazizadeh,

Mohammadi‐Bajgiran

et al. 2023

Clinical Laboratory Analysis

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BackgroundThe reference intervals (RIs) for liver function tests (LFTs) were determined in Iranian children for the first time.MethodsA total of 344 healthy pediatrics aged 3 days to 30 months old were recruited. Serum levels of ALT, AST, ALP, direct bilirubin, and total bilirubin were measured. RIs were determined using CLSI Ep28‐A3 guidelines.ResultsAll analytes demonstrated age‐specific differences except AST. ALT and ALP demonstrated significantly elevated levels in infants 0 to <5 months relative to the remainder of the age range. Direct and total bilirubin demonstrated markedly elevated levels in early life with mean of 0.28 mg/dL and 1.64 mg/dL observed for direct and total bilirubin, respectively, decreasing by ~50% in the adjacent partition.ConclusionThese novel data will help improve the clinical interpretation of biochemical test results in young Iranian neonates and children and can be of value to clinical laboratories with similar populations.

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Evaluation of acute and sub-chronic oral toxicities of Neoneaster in rats

Aramipour

Gholami

Saber

et al. 2023

Journal of Ethnopharmacology

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Recent clinical evidence in the herbal therapy of neonatal jaundice in Iran: A review

Cited by 4 publications

References 32 publications

Recent Advances in Adjuvant Pharmacotherapy for Neonatal Indirect Hyperbilirubinemia: A Narrative Review

Recent Advances in Adjuvant Pharmacotherapy for Neonatal Indirect Hyperbilirubinemia: A Narrative Review

Age‐specific reference intervals for liver function tests in healthy neonates, infants, and young children in Iran

Evaluation of acute and sub-chronic oral toxicities of Neoneaster in rats

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