Recent applications of ion mobility spectrometry in natural product research

Masike, Keabetswe; Stander, Maria A.; Villiers, André de

doi:10.1016/j.jpba.2020.113846

Cited by 33 publications

(28 citation statements)

References 259 publications

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“…The detailed information about these different platforms is summarized in previous review articles. [110][111][112] The size and shape information of the ionic analytes is related to a quantitative parameter, i.e., Page 27 of 58 CCS Chemistry collision cross sections (CCSs), which can be readily deconvoluted based on the m/z value and drift time of selected ions.…”

Section: Ion Mobility Mass Spectrometrymentioning

confidence: 99%

“…115 It is worth noting that, owing to the non-uniformed feature of the electronic field applied in mobility devices of TWIM and TIM, external calibrants are required to convert experimental arriving time distribution to an averaged CCS value (DTIM with static electronic filed does not require calibration, but could cause Page 30 of 58 CCS Chemistry fragmentation of the fragile metallo-supramolecules). 68,112 Thus, a suitable calibrant that has the similar interaction with the buffer gas and the analytic ions is demanded. The common calibrants are generally peptides and proteins which are capable of producing ions that can cover the CCS values of the analytes ions.…”

Section: Providing Structural Information Based On Ccssmentioning

confidence: 99%

“…The common calibrants are generally peptides and proteins which are capable of producing ions that can cover the CCS values of the analytes ions. 112 However, current CCS calibrants are mainly reported for (bio)macromolecules, none of them is ideal for metallo-supramolecules. 68 Consequently, errors are expected during quantitively analyzing the CCS values of the analytes prepared by coordination-driven self-assembly.…”

Section: Providing Structural Information Based On Ccssmentioning

confidence: 99%

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Multidimensional Mass Spectrometry Assisted Metallo-Supramolecular Chemistry

Wang

Guo

2022

CCS Chem

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Metallo-supramolecular chemistry based on the reversible, directional and predictable noncovalent interaction of metal-ligand coordination has been widely applied in constructing a myriad of two-dimensional and three-dimensional supramolecules with sophisticated structures. The development of metallosupramolecular chemistry highly relies on facile characterization methods. In the further advancement of structural complexity with desired functions, however, conventional crystallographic and spectroscopic characterizations were limited by crystal growth, sample purity and severe signal overlaps. With high sensitivity and low requirement for purity, multidimensional mass spectrometry (MS) including electrospray ionizationmass spectrometry (ESI-MS), tandem mass spectrometry (MS2), and ion mobility-mass spectrometry (IM-MS),

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Section: Ion Mobility Mass Spectrometrymentioning

confidence: 99%

Section: Providing Structural Information Based On Ccssmentioning

confidence: 99%

Section: Providing Structural Information Based On Ccssmentioning

confidence: 99%

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Multidimensional Mass Spectrometry Assisted Metallo-Supramolecular Chemistry

Wang

Guo

2022

CCS Chem

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“…Ben-Nissan et al discussed the application of IM-MS in the study of the structure/function of protein complexes [ 14 ]. Masike et al studied the application of IM-MS in natural products [ 15 ]. On the other hand, supercritical fluid chromatography tandem mass spectrometry (SFC-MS/MS) has attracted more and more attention due to its advantages of higher efficiency, shorter analysis time, and accurate characterization of compounds [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

A Rapid and Sensitive Method for the Simultaneous Determination of Multipolar Compounds in Plant Tea by Supercritical Fluid Chromatography Coupled to Ion Mobility Quadrupole Time-of-Flight Mass Spectrometry

Yue

Cao

2022

Foods

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In this study, matrix solid phase dispersion (MSPD) microextraction combined with supercritical fluid chromatography-ion mobility quadrupole time-of-flight mass spectrometry (SFC/IM-QTOF-MS) was used to analyze the multipolar compounds in plant tea. The parameters of stationary phase, mobile phase, make-up solution, temperature, and back pressure were optimized. The target analytes were gradient eluted in 8 min by supercritical CO2 on a Zorbax RX-SIL column. Collisional Cross Section (CCS) values for single and multiple fields were measured. A series of validation studies were carried out under the optimal conditions, and the linear relationship and reproducibility were good. The limits of detection were 1.4 (Scoparone (1))~70 (Naringenin (4)) ng/mL, and the limits of quantification were 4.7 (Scoparone (1))~241 (Naringenin (4)) ng/mL. The recoveries of most compounds ranged from 60.7% to 127%. As a consequence, the proposed method was used for the separation and quantitative analysis of active ingredients in caulis dendrobii.

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“…Nevertheless, there are still significant bottlenecks related to the resolving power of these IMS systems. These instrumental platforms have relatively low resolving power ( R = 40–60), which is only sufficient for resolving ions differing in CCS values by ∼2-3%, including different classes of lipids, but not for most stereoisomers (ΔCCS < 1%) and enantiomers (ΔCCS ∼0.1%) ( Masike et al, 2021 ). Recent technological advances in trapped ion mobility spectrometry (TIMS) ( Vasilopoulou et al, 2020 ), structures for lossless ion manipulations (SLIM) ( Wojcik et al, 2017 ), and cyclic ion mobility (cIM) systems ( Colson et al, 2019 ) have shown promise for more demanding analysis.…”

Section: Introductionmentioning

confidence: 99%

A Novel Approach to Characterize the Lipidome of Marine Archaeon Nitrosopumilus maritimus by Ion Mobility Mass Spectrometry

Law

Tao

et al. 2021

Front. Microbiol.

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Archaea are differentiated from the other two domains of life by their biomolecular characteristics. One such characteristic is the unique structure and composition of their lipids. Characterization of the whole set of lipids in a biological system (the lipidome) remains technologically challenging. This is because the lipidome is innately complex, and not all lipid species are extractable, separable, or ionizable by a single analytical method. Furthermore, lipids are structurally and chemically diverse. Many lipids are isobaric or isomeric and often indistinguishable by the measurement of mass or even their fragmentation spectra. Here we developed a novel analytical protocol based on liquid chromatography ion mobility mass spectrometry to enhance the coverage of the lipidome and characterize the conformations of archaeal lipids by their collision cross-sections (CCSs). The measurements of ion mobility revealed the gas-phase ion chemistry of representative archaeal lipids and provided further insights into their attributions to the adaptability of archaea to environmental stresses. A comprehensive characterization of the lipidome of mesophilic marine thaumarchaeon, Nitrosopumilus maritimus (strain SCM1) revealed potentially an unreported phosphate- and sulfate-containing lipid candidate by negative ionization analysis. It was the first time that experimentally derived CCS values of archaeal lipids were reported. Discrimination of crenarchaeol and its proposed stereoisomer was, however, not achieved with the resolving power of the SYNAPT G2 ion mobility system, and a high-resolution ion mobility system may be required for future work. Structural and spectral libraries of archaeal lipids were constructed in non-vendor-specific formats and are being made available to the community to promote research of Archaea by lipidomics.

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Recent applications of ion mobility spectrometry in natural product research

Cited by 33 publications

References 259 publications

Multidimensional Mass Spectrometry Assisted Metallo-Supramolecular Chemistry

Multidimensional Mass Spectrometry Assisted Metallo-Supramolecular Chemistry

A Rapid and Sensitive Method for the Simultaneous Determination of Multipolar Compounds in Plant Tea by Supercritical Fluid Chromatography Coupled to Ion Mobility Quadrupole Time-of-Flight Mass Spectrometry

A Novel Approach to Characterize the Lipidome of Marine Archaeon Nitrosopumilus maritimus by Ion Mobility Mass Spectrometry

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