Recent Advances on Development of Hydroxyapatite Coating on Biodegradable Magnesium Alloys: A Review

Abstract

The wide application of magnesium alloys as biodegradable implant materials is limited because of their fast degradation rate. Hydroxyapatite (HA) coating can reduce the degradation rate of Mg alloys and improve the biological activity of Mg alloys, and has the ability of bone induction and bone conduction. The preparation of HA coating on the surface of degradable Mg alloys can improve the existing problems, to a certain extent. This paper reviewed different preparation methods of HA coatings on biodegradable Mg alloys, and their effects on magnesium alloys’ degradation, biocompatibility, and osteogenic properties. However, no coating prepared can meet the above requirements. There was a lack of systematic research on the degradation of coating samples in vivo, and the osteogenic performance. Therefore, future research can focus on combining existing coating preparation technology and complementary advantages to develop new coating preparation techniques, to obtain more balanced coatings. Second, further study on the metabolic mechanism of HA-coated Mg alloys in vivo can help to predict its degradation behavior, and finally achieve controllable degradation, and further promote the study of the osteogenic effect of HA-coated Mg alloys in vivo.

Calcium Phosphate-Based Biomaterials for Bone Repair

“…Therefore, HAP is used widely for dental surgery, long bone defects, bone nonunion, vertebral fusion operation and maxillofacial repair [ 76 ]. The biocompatibility, osseointegration, and bioactivity of metal implants are improved by coating their surfaces with HAP, which enhances the bone contact area and cell adhesion properties of the implants [ 30 ]. Moreover, HAP can promote the biomineralization of macromolecule-based scaffolds.…”

Biodegradable Magnesium Biomaterials—Road to the Clinic

“…Having the ability to promote in vivo bone healing and regeneration and the mechanical properties similar to that of bones, Mg alloys with suitable coatings have the potential for use as biodegradable orthopedic implants [189][190][191]. These materials coated with calcium phosphate coatings based on hydroxyapatite and its various chemical analogues can further enhance biocompatibility [192], bioactivity [193], wear resistance [194], bone conduction, bone induction, and the degradation resistance of Mg biomaterials [195]. Gao et al [196] deposited calcium phosphate coating containing dicalcium phosphate dihydrate on an AZ60 alloy via the chemical conversion technique.…”

Role of Solvent Used in Development of Graphene Oxide Coating on AZ31B Magnesium Alloy: Corrosion Behavior and Biocompatibility Analysis

“…Properties like biodegradation, biocompatibility, bioactivity, and adaptation of Mg alloys can be standardized up to an estimated level by adjusting the corrosion rate with the aid of suitable coating such as hydroxyapatite, epoxy silane, graphene, etc. [ 16 , 17 , 18 , 19 ]. Graphene, a two-dimensional (2D) material, exhibits a honeycomb structure made up of a single layer of carbon atoms.…”