Recent advances of zwitterionic-based topological polymers for biomedical applications

Abstract

Zwitterionic polymers, comprising hydrophilic anionic and cationic groups with the same total number of positive and negative charges on the same monomer residue, have received increasing attention due to their...

Biorecognition antifouling coatings in complex biological fluids: a review of functionalization aspects

“…Nowadays, superior fouling resistance can be achieved using ultra-low fouling functionalizable platforms based on dense polymer brushes prepared by controlled surface-initiated polymerization of monomers 34,37,77–80 bearing zwitterionic phosphorylcholine, 81 sulfobetaine, 82 carboxybetaine groups, 83 or nonionic hydroxy-ended moieties. 84,85 Among those, poly(carboxybetaines) (pCBs) show enhanced antifouling properties, 50,86 while allowing easy functionalization with various BEs via their carboxyl group 22,87 which makes them a rather universal platform suitable for demanding applications.…”

Design principles of bioinspired interfaces for biomedical applications in therapeutics and imaging

“…Similar to PEG, zwitterionic materials are able to extend the blood circulation half-life of NPs without triggering the immune response (Pombo-Garcia et al, 2016). Zwitterionic materials are known to simultaneously possess cationic and anionic moieties in equal proportion, which enables overall charge neutrality and superhydrophilicity (Shao and Jiang, 2014;Zhang et al, 2022).…”

Poly(sulfur ylides): a new class of zwitterionic polymers with distinct thermal and solution behaviour

“…Such zwitterionic polymers have found widespread applications in the field of biomedical sciences because of their stimuli responsive nature. [1][2][3] Most zwitterionic polymers can either be classified as polybetaines or polyampholytes, in which the oppositely charged moieties are either located in a single repeating unit, or statistically distributed alongside the polymer chain, respectively (Figure 1). 4,5 New applications of such zwitterionic polymers including antifouling coatings, drug delivery vesicles and phase separators make new forms of zwitterionic polymers indispensable.…”

“…Such zwitterionic polymers have found widespread applications in the field of biomedical sciences because of their stimuli responsive nature. 1–3 Most zwitterionic polymers can either be classified as polybetaines or polyampholytes, in which the oppositely charged moieties are either located in a single repeating unit, or statistically distributed alongside the polymer chain, respectively (Fig. 1).…”

“…a c Weight content w of ylide monomer (SY) in copolymer. d Molecular weight M n determined by1 H NMR. e Molecular weight M n determined by SEC.…”