Recent Advances of Using Exosomes as Diagnostic Markers and Targeting Carriers for Cardiovascular Disease

Li, Ni; Zhang, Tianyuan; Zhu, Linwen; Sun, Lebo; Shao, Guofeng; Gao, Jianqing

doi:10.1021/acs.molpharmaceut.3c00268

Cited by 3 publications

(2 citation statements)

References 192 publications

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“…Cardiovascular health: Exosomes are being explored as diagnostic and therapeutic tools in cardiovascular diseases. They can carry molecules associated with heart conditions and may be used to monitor and treat heart diseases (Li N et al, 2023). Wang et al report that exosomes from induced pluripotent stem cells (iPSCs) transfer cardioprotective miRNAs, including miR-21 and miR-210, to cardiomyocytes.…”

Section: Regenerative Medicinementioning

confidence: 99%

Exosomes: a promising avenue for cancer diagnosis beyond treatment

Wang,

Qin

et al. 2024

Front. Cell Dev. Biol.

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Exosomes, extracellular vesicles secreted by cells, have garnered significant attention in recent years for their remarkable therapeutic potential. These nanoscale carriers can be harnessed for the targeted delivery of therapeutic agents, such as pharmaceuticals, proteins, and nucleic acids, across biological barriers. This versatile attribute of exosomes is a promising modality for precision medicine applications, notably in the realm of cancer therapy. However, despite their substantial therapeutic potential, exosomes still confront challenges tied to standardization and scalability that impede their practice in clinical applications. Moreover, heterogeneity in isolation methodologies and limited cargo loading mechanisms pose obstacles to ensuring consistent outcomes, thereby constraining their therapeutic utility. In contrast, exosomes exhibit a distinct advantage in cancer diagnosis, as they harbor specific signatures reflective of the tumor’s genetic and proteomic profile. This characteristic endows them with the potential to serve as valuable liquid biopsies for non-invasive and real-time monitoring, making possible early cancer detection for the development of personalized treatment strategies. In this review, we provide an extensive evaluation of the advancements in exosome research, critically examining their advantages and limitations in the context of cancer therapy and early diagnosis. Furthermore, we present a curated overview of the most recent technological innovations utilizing exosomes, with a focus on enhancing the efficacy of early cancer detection.

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Section: Regenerative Medicinementioning

confidence: 99%

Exosomes: a promising avenue for cancer diagnosis beyond treatment

Wang,

Qin

et al. 2024

Front. Cell Dev. Biol.

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“…In summary, exosomes derived from regenerative cell types such as cardiac progenitors and mesenchymal stem cells represent a promising new approach to stimulating myocardial regeneration after injury. However, additional research is needed to determine the full potential of these materials for cardiac repair 105 , 106 . Challenges remain in exosome isolation methods, the optimization of exosome cargo, scaling production, and improving delivery/retention.…”

Section: Applications Of Exosome-loaded Biomaterialsmentioning

confidence: 99%

Engineered exosomes and composite biomaterials for tissue regeneration

Hu,

Wang,

Chen

et al. 2024

Theranostics

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Exosomes, which are small vesicles enclosed by a lipid bilayer and released by many cell types, are widely dispersed and have garnered increased attention in the field of regenerative medicine due to their ability to serve as indicators of diseases and agents with therapeutic potential. Exosomes play a crucial role in mediating intercellular communication through the transfer of many biomolecules, including proteins, lipids, RNA, and other molecular constituents, between cells. The targeted transport of proteins and nucleic acids to specific cells has the potential to enhance or impair specific biological functions. Exosomes have many applications, and they can be used alone or in combination with other therapeutic approaches. The examination of the unique attributes and many functions of these factors has emerged as a prominent field of study in the realm of biomedical research. This manuscript summarizes the origins and properties of exosomes, including their structural, biological, physical, and chemical aspects. This paper offers a complete examination of recent progress in tissue repair and regenerative medicine, emphasizing the possible implications of these methods in forthcoming tissue regeneration attempts.

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Noble Metal Nanoparticle‐Based Aptasensors: A Powerful Tool for Exosomal Detection

Sun,

Hu,

et al. 2024

Advanced Sensor Research

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Exosomes, secreted by various types of cells, play a crucial role in cell‐to‐cell communication by transporting essential molecular cargos that largely mirror the pathophysiological attributes of their parent cells. Increasing evidence has shown that exosomes emerge as the reliable early biomarkers for different diseases. Clearly, exosomal detection with a high sensitivity and specificity becomes highly essential to advance the understanding of disease progression and to develop early diagnostic modalities. Among different types of biosensors, aptasensors have received significant attention as the diagnostic tools considering their programmability and targeting ability. Noble metal nanomaterials possess distinctive physicochemical properties, allowing for ready functionalization with aptamers via both physical adsorption and chemical immobilization. By utilizing the aptamers as the recognition elements, noble metal nanoparticle‐based aptasensors offer a promising platform for rapid, cost‐effective, and sensitive in situ detection of exosomes. In this review, the progress will summarized in exosomes as a biomarker for diseases and the recent advances in the use of noble metal nanoparticle/aptamer‐based sensors for analysis of exosomes and other extracellular vesicles.

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Recent Advances of Using Exosomes as Diagnostic Markers and Targeting Carriers for Cardiovascular Disease

Cited by 3 publications

References 192 publications

Exosomes: a promising avenue for cancer diagnosis beyond treatment

Exosomes: a promising avenue for cancer diagnosis beyond treatment

Engineered exosomes and composite biomaterials for tissue regeneration

Noble Metal Nanoparticle‐Based Aptasensors: A Powerful Tool for Exosomal Detection

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