Recent advances of restricted access molecularly imprinted materials and their applications in food and biological samples analysis

Wang, Hongwei; Huang, Chao; Ma, Shujuan; Bo, Chunmiao; Ou, Junjie; Gong, Bolin

doi:10.1016/j.trac.2022.116526

Cited by 25 publications

(15 citation statements)

References 135 publications

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“…MIPs have some advantages, such as low cost, good physicochemical stability, resistance to harsh environments and reusability [ 5 ]. Unfortunately, some macromolecules in real samples can be retained on the surfaces of MIPs, resulting in the selective binding sites being blocked that reduce selectivity [ 6 ]. Moreover, targets in complex samples cannot be specifically recognized due to interferences by other substances through nonspecific binding.…”

Section: Introductionmentioning

confidence: 99%

Molecularly Imprinting–Aptamer Techniques and Their Applications in Molecular Recognition

Zhou

Liu

2022

Biosensors

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Molecular imprinting–aptamer techniques exhibit the advantages of molecular imprinting and aptamer technology. Hybrids of molecularly imprinted polymer–aptamer (MIP–aptamer) prepared by this technique have higher stability, binding affinity and superior selectivity than conventional molecularly imprinted polymers or aptamers. In recent years, molecular imprinting–aptamer technologies have attracted considerable interest for the selective recognition of target molecules in complex sample matrices and have been used in molecular recognition such as antibiotics, proteins, viruses and pesticides. This review introduced the development of molecular imprinting–aptamer-combining technologies and summarized the mechanism of MIP–aptamer formation. Meanwhile, we discussed the challenges in preparing MIP–aptamer. Finally, we summarized the application of MIP–aptamer to the molecular recognition in disease diagnosis, environmental analysis, food safety and other fields.

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Section: Introductionmentioning

confidence: 99%

Molecularly Imprinting–Aptamer Techniques and Their Applications in Molecular Recognition

Zhou

Liu

2022

Biosensors

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“…This type of configuration offers essential qualities such as simplicity, high reproducibility, and analytical frequency. 6,7 A large number of published analytical methods have been used as restricted access molecularly imprinted polymer (RAMIP), especially those coated with bovine serum albumin (RAMIP-BSA), as an adsorbent in online or offline analytical systems. [8][9][10] These materials are based on molecularly imprinted polymers (MIPs) which are synthetic polymers capable of recognizing specific molecules in terms of shape, size, and chemical functionality.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, for the formation of the 3D network around the template are also necessary an initiator, a crossliker, and a porogenic solvent. 7,11 Though MIPs exhibit selectivity properties for one analyte or its chemical class, they only can be properly used in sample preparation of complex matrices if their surface were modified to become RAMs. 10 Santos et al achieved higher selectivity and protein elimination capacity with a RAMIP-BSA developed to simultaneously extract and quantify amitriptyline from biological matrices (human plasma) in an online extraction configuration.…”

Section: Introductionmentioning

confidence: 99%

“…This type of configuration offers essential qualities such as simplicity, high reproducibility, and analytical frequency. 6,7…”

Section: Introductionmentioning

confidence: 99%

“…In addition, for the formation of the 3D network around the template are also necessary an initiator, a cross-liker, and a porogenic solvent. 7,11 Though MIPs exhibit selectivity properties for one analyte or its chemical class, they only can be properly used in sample preparation of complex matrices if their surface were modified to become RAMs. 10…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Online restricted access molecularly imprinted solid-phase extraction coupled with liquid chromatography-mass spectrometry for the selective determination of serum bile acids

Silveira

Barbosa

Faria

et al. 2022

Analyst

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Preparation of copolymer brush‐type restricted access microspheres with adjustable adsorption selectivity to variety of dyes

Bo,

Tang,

Jia

et al. 2023

J of Applied Polymer Sci

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Restricted access materials (RAMs) with adjustable selectivity was developed for the removal and detection of residual dyes for the solve problems of dye contamination. In this work, using homemade poly(4‐vinylbenzyl chloride‐co‐divinylbenzene) (PVBC/DVB) microspheres as substrate and successive two‐step surface‐initiated atom transfer radical polymerization (SI‐ATRP) as synthesis method, the two types of monomers, sodium 4‐vinylbenzene sulfonate (Nass) and styrene (St) were first grafted for constructing mixed interactions of adsorption sites, and then the hydrophilic glycidyl methacrylate (GMA) was polymerized, following by hydrolysis to construct diol groups on the external PVBC/DVB as the restricted access sites. The developed PVBC/DVB@poly(St‐co‐Nass)@poly(GMA) of adsorption properties was investigated by six dyes including methylene blue (MB), basic fuchsin (BF), acid fuchsin (AF), neutral red (NR), methyl orange (MO), and Congo red (CR), the adsorption capacities of those dyes and the removal rate for the binary mixed dye solution both rely on the ratio of St/Nass, confirming the adjustable adsorption selectivity. When PVBC/DVB@poly(St‐co‐Nass)@poly(GMA) was packed as solid phase extraction adsorbent in couple with UV–vis spectrum, it was applied to the determination of MB and BF in the water, fish and shrimp, good linearity with satisfactory recoveries for MB and BF are obtained to show the favorable practicability.

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Recent advances of restricted access molecularly imprinted materials and their applications in food and biological samples analysis

Cited by 25 publications

References 135 publications

Molecularly Imprinting–Aptamer Techniques and Their Applications in Molecular Recognition

Molecularly Imprinting–Aptamer Techniques and Their Applications in Molecular Recognition

Online restricted access molecularly imprinted solid-phase extraction coupled with liquid chromatography-mass spectrometry for the selective determination of serum bile acids

Preparation of copolymer brush‐type restricted access microspheres with adjustable adsorption selectivity to variety of dyes

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