Recent advances of polyoxometalates in multi-functional imaging and photothermal therapy

Kong, Xueping; Wan, Guofeng; Li, Bao; Wu, Lixin

doi:10.1039/d0tb01375g

Cited by 50 publications

(38 citation statements)

References 129 publications

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“…The TRIS-MnPOMo-loaded micelles (TRIS-MnPOMo@SPB and TRIS-MnPOMo@SP) were prepared using the dialysis method; this method is one of the best preparation protocols for micelle formation and has been fully studied before. , Based on our knowledge, there is no similar report for entrapping TRIS-MnPOMo in SPB, so it is not easy to verify the results based on evidence. However, some similar studies, such as those reported by Bu et al and Zhang et al, that reported the preparation of other POM-loaded nanoparticles − are available.…”

Section: Resultsmentioning

confidence: 94%

Biotin-Targeted Nanomicellar Formulation of an Anderson-Type Polyoxomolybdate: Synthesis and In Vitro Cytotoxicity Evaluations

et al. 2021

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This study is aimed at developing a micellar carrier for an Anderson-type manganese polyoxomolybdate (TRIS-MnPOMo) to improve the potency and reduce the general toxicity. The biotin-targeted stearic acid–polyethylene glycol (SPB) polymeric conjugate was selected for the first time as a micelle-forming basis for the delivery of TRIS-MnPOMo to breast cancer cells. The cytotoxicity of TRIS-MnPOMo and its nanomicellar form (TRIS-MnPOMo@SPB) was evaluated against MCF-7, MDA-MB-231 (breast cancer cell lines), and HUVEC (normal cell line) in vitro using the MTT assay. The quantity of cellular uptake and apoptosis level were studied properly using standard methods. The hydrodynamic size, zeta potential, and polydispersity index of the prepared micelles were 140 nm, −15.6 mV, and 0.16, respectively. The critical micelle concentration was about 30 μg/mL, which supports the colloidal stability of the micellar dispersion. The entrapment efficiency was interestingly high (about 82%), and a pH-responsive release of TRIS-MnPOMo was successfully achieved. The micellar form showed better cytotoxicity than the free TRIS-MnPOMo on cancer cells without any significant heme and normal cell toxicity. Biotin-targeted nanomicelles internalized into the MDA-MB-231 cells interestingly better than nontargeted micelles and TRIS-MnPOMo, most probably via the endocytosis pathway. Furthermore, at the same concentration, micelles remarkably increased the level of induced apoptosis in MDA-MB-231 cells. In conclusion, TRIS-MnPOMo@SPB could profoundly improve potency, safety, and cellular uptake; these results are promising for further evaluations in vivo.

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Section: Resultsmentioning

confidence: 94%

Biotin-Targeted Nanomicellar Formulation of an Anderson-Type Polyoxomolybdate: Synthesis and In Vitro Cytotoxicity Evaluations

et al. 2021

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“…As shown in Figure c and Figure S20, the efficiencies of the core@shell (30%) and lateral heterostructures (24.7%) are much higher than that of the SnS 2 nanoplates (0.47%). This indicates that the photothermal conversion effect mainly arises from the metallic Sn 0.5 Mo 0.5 S 2 nanosheets, where the energy of the excited electrons is released in the form of heat via electron hopping . In addition, based on the calculated work function of SnS 2 (5.2 eV) and Sn 0.5 Mo 0.5 S 2 (4.8 eV), an ohmic contact might form at the SnS 2 /Sn 0.5 Mo 0.5 S 2 heterointerface, affording rapid electron transport in the heterointerface and preventing electron–hole recombination in SnS 2 (Figure d). , Therefore, the photogenerated electrons in SnS 2 are likely transferred to the metallic Sn 0.5 Mo 0.5 S 2 and participate in the above-mentioned heating process.…”

Section: Results and Discussionmentioning

confidence: 99%

Spatially Controlled Preparation of Layered Metallic–Semiconducting Metal Chalcogenide Heterostructures

et al. 2021

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Spatially controlled preparation of heterostructures composed of layered materials is important in achieving interesting properties. Although vapor-phased deposition methods can prepare vertical and lateral heterostructures, liquid-phased methods, which can enable scalable production and further solution processes, have shown limited controllability. Herein, we demonstrate by using wet chemical methods that metallic Sn 0.5 Mo 0.5 S 2 nanosheets can be deposited epitaxially on the edges of semiconducting SnS 2 nanoplates to form SnS 2 /Sn 0.5 Mo 0.5 S 2 lateral heterostructures or coated on both the edges and basal surfaces of SnS 2 to give SnS 2 @Sn 0.5 Mo 0.5 S 2 core@shell heterostructures. They also showed good light-to-heat conversion ability due to the metallic property of Sn 0.5 Mo 0.5 S 2 . In particular, the core@shell heterostructure showed a higher photothermal conversion efficiency than the lateral counterpart, largely due to its randomly oriented and polycrystalline Sn 0.5 Mo 0.5 S 2 layers with larger interfacing area for multiple internal light scattering.

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“…As it stands, inadequate penetration depths and the low MPE of commonly utilized 808 nm lasers restrict the application of PTT/CDT. Based on standards set by the Food and Drug Administration (FDA), the clinically approved MPE for skin is 0.33 W cm −2 for an 808 nm laser and 1.0 W cm −2 for a 1064 nm laser [ 65 ]. Therefore, research into the development of more effective PTT/CDT has shifted toward identifying nanoplatforms that can take advantage of and increase the therapeutic potential of the deeper penetrating NIR-II biowindow [ 66 , 67 ].…”

Section: Nanoplatforms For Ptt/cdt In the Nir-ii Biowindowmentioning

confidence: 99%

Recent Advances in Single Fe-Based Nanoagents for Photothermal–Chemodynamic Cancer Therapy

et al. 2022

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Monomodal cancer therapies are often unsatisfactory, leading to suboptimal treatment effects that result in either an inability to stop growth and metastasis or prevent relapse. Thus, synergistic strategies that combine different therapeutic modalities to improve performance have become the new research trend. In this regard, the integration of photothermal therapy (PTT) with chemodynamic therapy (CDT), especially PTT/CDT in the second near-infrared (NIR-II) biowindow, has been demonstrated to be a highly efficient and relatively safe concept. With the rapid development of nanotechnology, nanoparticles can be designed from specific elements, such as Fe, that are equipped with both PTT and CDT therapeutic functions. In this review, we provide an update on the recent advances in Fe-based nanoplatforms for combined PTT/CDT. The perspectives on further improvement of the curative efficiency are described, highlighting the important scientific obstacles that require resolution in order to reach greater heights of clinical success. We hope this review will inspire the interest of researchers in developing novel Fe-based nanomedicines for multifunctional theranostics.

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Recent advances of polyoxometalates in multi-functional imaging and photothermal therapy

Abstract: Polyoxometalates as a kind of molecular metal-oxide clusters with precise chemical composition and architecture have been demonstrated to show various potentials in multidisciplinary materials. Accompanying by their direct chemical interaction...

Cited by 50 publications

References 129 publications

Biotin-Targeted Nanomicellar Formulation of an Anderson-Type Polyoxomolybdate: Synthesis and In Vitro Cytotoxicity Evaluations

Biotin-Targeted Nanomicellar Formulation of an Anderson-Type Polyoxomolybdate: Synthesis and In Vitro Cytotoxicity Evaluations

Spatially Controlled Preparation of Layered Metallic–Semiconducting Metal Chalcogenide Heterostructures

Recent Advances in Single Fe-Based Nanoagents for Photothermal–Chemodynamic Cancer Therapy

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