Recent Advances in Single Fe-Based Nanoagents for Photothermal–Chemodynamic Cancer Therapy

Abstract

Monomodal cancer therapies are often unsatisfactory, leading to suboptimal treatment effects that result in either an inability to stop growth and metastasis or prevent relapse. Thus, synergistic strategies that combine different therapeutic modalities to improve performance have become the new research trend. In this regard, the integration of photothermal therapy (PTT) with chemodynamic therapy (CDT), especially PTT/CDT in the second near-infrared (NIR-II) biowindow, has been demonstrated to be a highly efficient and relatively safe concept. With the rapid development of nanotechnology, nanoparticles can be designed from specific elements, such as Fe, that are equipped with both PTT and CDT therapeutic functions. In this review, we provide an update on the recent advances in Fe-based nanoplatforms for combined PTT/CDT. The perspectives on further improvement of the curative efficiency are described, highlighting the important scientific obstacles that require resolution in order to reach greater heights of clinical success. We hope this review will inspire the interest of researchers in developing novel Fe-based nanomedicines for multifunctional theranostics.

PPy@Fe3O4 nanoparticles inhibit the proliferation and metastasis of CRC via suppressing the NF-κB signaling pathway and promoting ferroptosis

“…CDT/PTT has demonstrated to be highly effective and relatively safe, and it can directly ablate cancer cells as well. Additionally, photothermal effects during PTT can speed up the Fenton-based process’ reaction rate and enhance CDT ( Yu et al, 2021 ; Zhang et al, 2022 ). With the development of nanotechnology, various targeted and multifunctional nanoparticles have been reported, which can deliver drugs and directly or indirectly activate the immune system to kill cancer cells ( Hooftman and O'Neill, 2022 ; Luo et al, 2021 ; Sun et al, 2021 ).…”

Copper Iron Chalcogenide Semiconductor Nanocrystals in Energy and Optoelectronics Applications—State of the Art, Challenges, and Future Potential

“…CuFeSe 2 NCs have also been used for PTT. [ 129,130 ] Jiang et al. reported the highest photothermal conversion efficiencies so far, 82%, with 5 nm CuFeSe 2 nanoparticles.…”

“…CuFeSe 2 NCs have also been used for PTT. [129,130] Jiang et al reported the highest photothermal conversion efficiencies so far, 82%, with 5 nm CuFeSe 2 nanoparticles. For an example, Figure 9e compares the CT images and X-ray attenuation of [127] Copyright 2017, The Royal Society of Chemistry.…”

Targeting Tumor Microenvironment by Metal Peroxide Nanoparticles in Cancer Therapy

“…Before precisely designing a Fenton/ Fenton-like reaction-based nanomedicine, it is important to take into account the feasibility of active redox cycles in the pH state, catalyst loading, and stability of oxidation products. Te full potential of chemodynamic cancer therapy is frequently limited by the intricacy of TME and the preparation of an "all-in-one" chemodynamic drug [124]. Designing appropriate Fenton nanosystems and modifying TME in favour of CDT is therefore of utmost importance.…”