Recent Advances of Natural-Polymer-Based Hydrogels for Wound Antibacterial Therapeutics

Zhao, Yunhui; Wang, Xiaoyu; Qi, Ruilian; Yuan, Hang

doi:10.3390/polym15153305

Cited by 9 publications

(1 citation statement)

References 117 publications

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“…Natural polymer hydrogels are polymeric networks loaded with natural bioactive compounds that can act as good wound dressings due to their versatile physicochemical properties, represented mainly by a high water absorption capacity. Moreover, they pro-vide a temporary structure facilitating cell infiltration and proliferation, and due to their biodegradability, they are gradually replaced by new ECM [71]. The stretching properties confer to hydrogels good adherence to tissue wounds of different shapes.…”

Section: Recent Development Of Hydrogels Encapsulating Small Molecule...mentioning

confidence: 99%

Natural Polymeric Hydrogels Encapsulating Small Molecules for Diabetic Wound Healing

Oprita,

Iosageanu,

Craciunescu

2023

Gels

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Diabetes is a condition correlated with a high number of diagnosed chronic wounds as a result of a complex pathophysiological mechanism. Diabetic chronic wounds are characterized by disorganized and longer stages, compared to normal wound healing. Natural polymer hydrogels can act as good wound dressings due to their versatile physicochemical properties, represented mainly by high water content and good biocompatibility. Natural bioactive hydrogels are polymers loaded with bioactive compounds providing antibacterial and antioxidant properties, modulation of inflammation and adherence to wounded tissue, compared to traditional dressings, which enables promising future applications for diabetic wound healing. Natural bioactive compounds, such as polyphenols, polysaccharides and proteins have great advantages in promoting chronic wound healing in diabetes due to their antioxidant, anti-inflammatory, antimicrobial, anti-allergic and wound healing properties. The present paper aims to review the wound healing mechanisms underlining the main issues of chronic wounds and those specifically occurring in diabetes. Also, the review highlights the recent state of the art related to the effect of hydrogels enriched with natural bioactive compounds developed as biocompatible functional materials for improving diabetic-related chronic wound healing and providing novel therapeutic strategies that could prevent limb amputation and increase the quality of life in diabetic patients.

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Section: Recent Development Of Hydrogels Encapsulating Small Molecule...mentioning

confidence: 99%

Natural Polymeric Hydrogels Encapsulating Small Molecules for Diabetic Wound Healing

Oprita,

Iosageanu,

Craciunescu

2023

Gels

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Antimicrobial Hydrogels: Potential Materials for Medical Application

Li,

Han,

et al. 2023

Small

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Microbial infections based on drug‐resistant pathogenic organisms following surgery or trauma and uncontrolled bleeding are the main causes of increased mortality from trauma worldwide. The prevalence of drug‐resistant pathogens has led to a significant increase in medical costs and poses a great threat to the normal life of people. This is an important issue in the field of biomedicine, and the emergence of new antimicrobial materials hydrogels holds great promise for solving this problem. Hydrogel is an important material with good biocompatibility, water absorption, oxygen permeability, adhesion, degradation, self‐healing, corrosion resistance, and controlled release of drugs as well as structural diversity. Bacteria‐disturbing hydrogels have important applications in the direction of surgical treatment, wound dressing, medical device coating, and tissue engineering. This paper reviews the classification of antimicrobial hydrogels, the current status of research, and the potential of antimicrobial hydrogels for one application in biomedicine, and analyzes the current research of hydrogels in biomedical applications from five aspects: metal‐loaded hydrogels, drug‐loaded hydrogels, carbon‐material‐loaded hydrogels, hydrogels with fixed antimicrobial activity and biological antimicrobial hydrogels, and provides an outlook on the high antimicrobial activity, biodegradability, biocompatibility, injectability, clinical applicability and future development prospects of hydrogels in this field.

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A novel cathelicidin TS-CATH derived from Thamnophis sirtalis combats drug-resistant gram-negative bacteria in vitro and in vivo

Wang,

Zhang,

et al. 2024

Computational and Structural Biotechnology Journal

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Recent Advances of Natural-Polymer-Based Hydrogels for Wound Antibacterial Therapeutics

Cited by 9 publications

References 117 publications

Natural Polymeric Hydrogels Encapsulating Small Molecules for Diabetic Wound Healing

Natural Polymeric Hydrogels Encapsulating Small Molecules for Diabetic Wound Healing

Antimicrobial Hydrogels: Potential Materials for Medical Application

A novel cathelicidin TS-CATH derived from Thamnophis sirtalis combats drug-resistant gram-negative bacteria in vitro and in vivo

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