Natural Polymeric Hydrogels Encapsulating Small Molecules for Diabetic Wound Healing

Oprita, Elena Iulia; Iosageanu, Andreea; Craciunescu, Oana

doi:10.3390/gels9110867

Cited by 4 publications

(1 citation statement)

References 99 publications

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“…Gelatin-based hydrogels : Gelatin is a product derived from partial denaturation and hydrolysis of collagen, which presents excellent tissue compatibility, biodegradability, and hemostatic properties. 239 Gelatin hydrogels provide abundant cell adhesion sites that promote cell migration and tissue remodeling. 240 Despite these advantages, the properties of gelation alone are not always sufficient for demanding biomimetic scaffolds, particularly those designed for complex tissues like cartilage.…”

Section: Hydrogels For Cell Therapymentioning

confidence: 99%

Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions

Lu,

Ruan,

Huang

et al. 2024

Sig Transduct Target Ther

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The applications of hydrogels have expanded significantly due to their versatile, highly tunable properties and breakthroughs in biomaterial technologies. In this review, we cover the major achievements and the potential of hydrogels in therapeutic applications, focusing primarily on two areas: emerging cell-based therapies and promising non-cell therapeutic modalities. Within the context of cell therapy, we discuss the capacity of hydrogels to overcome the existing translational challenges faced by mainstream cell therapy paradigms, provide a detailed discussion on the advantages and principal design considerations of hydrogels for boosting the efficacy of cell therapy, as well as list specific examples of their applications in different disease scenarios. We then explore the potential of hydrogels in drug delivery, physical intervention therapies, and other non-cell therapeutic areas (e.g., bioadhesives, artificial tissues, and biosensors), emphasizing their utility beyond mere delivery vehicles. Additionally, we complement our discussion on the latest progress and challenges in the clinical application of hydrogels and outline future research directions, particularly in terms of integration with advanced biomanufacturing technologies. This review aims to present a comprehensive view and critical insights into the design and selection of hydrogels for both cell therapy and non-cell therapies, tailored to meet the therapeutic requirements of diverse diseases and situations.

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Section: Hydrogels For Cell Therapymentioning

confidence: 99%

Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions

Lu,

Ruan,

Huang

et al. 2024

Sig Transduct Target Ther

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Hydrogels for Nucleic Acid Drugs Delivery

Liu,

Xi,

Fan

et al. 2024

Adv Healthcare Materials

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Nucleic acid drugs are one of the hot spots in the field of biomedicine in recent years, and play a crucial role in the treatment of many diseases. However, its low stability and difficulty in target drug delivery are the bottlenecks restricting its application. Hydrogels are proven to be promising for improving the stability of nucleic acid drugs, reducing the adverse effects of rapid degradation, sudden release, and unnecessary diffusion of nucleic acid drugs. In this review, the strategies of loading nucleic acid drugs in hydrogels are summarized for various biomedical research, and classify the mechanism principles of these strategies, including electrostatic binding, hydrogen bond based binding, hydrophobic binding, covalent bond based binding and indirect binding using various carriers. In addition, this review also describes the release strategies of nucleic acid drugs, including photostimulation‐based release, enzyme‐responsive release, pH‐responsive release, and temperature‐responsive release. Finally, the applications and future research directions of hydrogels for delivering nucleic acid drugs in the field of medicine are discussed.

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State‐of‐the‐Art and Future Challenges of Smart Wound Dressings for Diabetic Foot Ulcer Treatment

Szunerits,

Boukherroub

2024

Advanced NanoBiomed Research

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The slow healing process of diabetic wound due to persisting infections in wound bed, owing to hyperglycemia, makes the search for efficient treatments pending. While it is complicated to increase the wound closure rate in diabetic‐related wounds due to the complex pathology, the treatment of such wound with hydrogels is seen as a promising approach and pursued over the years. However, where is this research currently standing in terms of clinical translation of these different multifunctional and stimuli‐responsive hydrogel bandages to accelerate diabetic foot ulcer healing and help to improve the life of the patients and the future of diabetic wound management? This perspective article will review some of the most important advancements in the field and will conclude with some perspectives, considered as relevant in the clinical context.

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Natural Polymeric Hydrogels Encapsulating Small Molecules for Diabetic Wound Healing

Cited by 4 publications

References 99 publications

Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions

Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions

Hydrogels for Nucleic Acid Drugs Delivery

State‐of‐the‐Art and Future Challenges of Smart Wound Dressings for Diabetic Foot Ulcer Treatment

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