Recent Advances of Nanostructures in Antimicrobial Therapy

He, Zhiyao; Wei, Xiawei; Wei, Yuquan

doi:10.1016/b978-0-323-52733-0.00007-0

Cited by 3 publications

(3 citation statements)

References 149 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nanobodies are small, single-domain and stable fragments of antibody with approximately 15 kDa weight [51]. Conjugation of specific nanobodies as one of functional group to the surface of dendrimer will allow active targeting of bacteria [21]. Similarly, using of aptamers, small oligonucleotides, is suitable option compared with antibody.…”

Section: Dendrimersmentioning

confidence: 99%

Dendrimers as Antimicrobial Agents in the Central Nervous System Infections. A Review

Kucková

Bhide

2023

Folia Veterinaria

View full text Add to dashboard Cite

Bacterial meningitis is a serious infection of the central nervous system that affects people all over the world. Streptococcus pneumoniae and Neisseria meningitidis are the most common pathogens causing meningeal inflammation in Europe. Treatment with standard antibiotics is becoming ineffective, not only due to their inability to cross the blood-brain barrier, but also due to rising antibiotic resistance. As a result, novel therapeutics to combat the infection are required. A promising solution could be therapeutic nanomolecules, such as dendrimers, some of which have antimicrobial properties due to their chemical structure. Additionally, they may be decorated with a suitable therapeutic and central nervous system homing peptides to construct nano-drug delivery systems, which can effectively cross the blood-brain barrier. To synthesize safe dendrimeric nano-drug delivery system it is necessary to select the best dendrimer candidates with antimicrobial activity and to understand pharmacosafety, pharmacokinetics and dynamics. This review provides a brief overview of dendrimers and their antimicrobial properties as they have been studied in relation to the blood-brain barrier and existing antibiotics.

show abstract

Section: Dendrimersmentioning

confidence: 99%

Dendrimers as Antimicrobial Agents in the Central Nervous System Infections. A Review

Kucková

Bhide

2023

Folia Veterinaria

View full text Add to dashboard Cite

show abstract

“…The lipid nanoparticle formulations such as Amphotec (Sequus Pharmaceuticals, Inc.), which is lipid nanoparticles loaded with amphotericin, and MEGACE ES (Par Pharmaceutical Companies, Inc.), which is nanoparticles loaded with megestrol acetate, have been approved by the FDA. The nanodendrimer (VivaGel, Starpharma Holdings Limited) formulated as a water‐based gel and delivered vaginally now has European Union regulatory approval for the topical treatment and rapid relief of bacterial vaginosis [116]. Furthermore, there are several studies on inorganic nanoparticles as antimicrobial agents which are needed to be clinically translated.…”

Section: Recent Advances In the Field Of Nanomedicinementioning

confidence: 99%

Nanomedicine for anticancer and antimicrobial treatment: an overview

Kulshrestha

Khan

2018

IET nanobiotechnol.

View full text Add to dashboard Cite

Nanoparticle-based treatment has become a potential therapeutic approach. The nanosize of these particles provides them with unique physicochemical properties and enhances their interaction with the biological system. Nanomaterials have the potential to overcome some of the major issues in the clinical world which may include cancer treatment and may be utilised to resolve the major problem of drug resistance in infection control. These particles are being used to improve present therapeutics by virtue of their shape, size and diverse intrinsic as well as chemical properties. The authors have discussed the use of nanoparticles in cancer treatment, infections caused by multidrug-resistant microbial strains and biofilm inhibition along with the detailed description of the current status of nanomaterials in the field of medicine.

show abstract

“…Therefore, a human-readable equivalent version of the NCD is created which allows design modifications exploiting an open source java based set of RapidSmith [22], [23]. We modified the RapidSmith based router published in [24] and such created our own rerouter which contains all nets of the design within the predetermined area on chip. When the XDL file is repaired by the rerouter, it is reconverted to NCD using the -xdl2ncd command.…”

Section: B Implementation Methodologymentioning

confidence: 99%

Adaptive reconfigurable voting for enhanced reliability in medium-grained fault tolerant architectures

Veljković

Riesgo

Torre

2015

2015 NASA/ESA Conference on Adaptive Hardware and Systems (AHS)

View full text Add to dashboard Cite

Abstract-The impact of SRAM-based FPGAs is constantly growing in aerospace industry despite the fact that their volatile configuration memory is highly susceptible to radiation effects. Therefore, strong fault-handling mechanisms have to be developed in order to protect the design and make it capable of fighting against both soft and permanent errors. In this paper, a fully reconfigurable medium-grained triple modular redundancy (TMR) architecture which forms part of a runtime adaptive onboard processor (OBP) is presented. Fault mitigation is extended to the voting mechanism by applying our reconfiguration methodology not only to domain replicas but also to the voter itself. The proposed approach takes advantage of adaptive configuration placement and modular property of the OBP, thus allowing on-line creation of different medium-grained TMRs and selection of their granularity level. Consequently, we are able to narrow down the fault-affected area thus making the error recovery process faster and less power consuming. The conventional hardware based voting is supported by the ICAPbased one in order to additionally strengthen the reconfigurable intermediate voting. In addition, the implementation methodology ensures using only one memory footprint for all voters and their voting adaptations thus saving storing resources in expensive rad-hard memories.

show abstract

Recent Advances of Nanostructures in Antimicrobial Therapy

Cited by 3 publications

References 149 publications

Dendrimers as Antimicrobial Agents in the Central Nervous System Infections. A Review

Dendrimers as Antimicrobial Agents in the Central Nervous System Infections. A Review

Nanomedicine for anticancer and antimicrobial treatment: an overview

Adaptive reconfigurable voting for enhanced reliability in medium-grained fault tolerant architectures

Contact Info

Product

Resources

About