Nanomedicine for anticancer and antimicrobial treatment: an overview

Kulshrestha, Shatavari; Khan, Asad U.

doi:10.1049/iet-nbt.2018.5112

Cited by 12 publications

(8 citation statements)

References 111 publications

(134 reference statements)

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“…The product was purified by column chromatography. 1 H NMR (400 MHz, CDCl 3 ): 19 PB Synthesis. The synthesis was performed as described with some modifications.…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…During the last 40 years, nanoparticles (NPs) have evolved as carrier systems for tissue-and cell type-directed drug delivery to reduce adverse effects of active pharmaceutical ingredients. 1 However, the efficacy at which systemically applied NPs deliver drugs to specific cell types in vivo is still far from optimal. 2 The first generation of NPs developed for tumor targeting, e.g., Doxil, exploited passive accumulation within solid tumors by the enhanced permeability and retention (EPR) effect.…”

Section: Introductionmentioning

confidence: 99%

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Density of Conjugated Antibody Determines the Extent of Fc Receptor Dependent Capture of Nanoparticles by Liver Sinusoidal Endothelial Cells

et al. 2021

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Despite considerable progress in the design of multifunctionalized nanoparticles (NPs) that selectively target specific cell types, their systemic application often results in unwanted liver accumulation. The exact mechanisms for this general observation are still unclear. Here we asked whether the number of cell-targeting antibodies per NP determines the extent of NP liver accumulation and also addressed the mechanisms by which antibody-coated NPs are retained in the liver. We used polysarcosine-based peptobrushes (PBs), which in an unmodified form remain in the circulation for >24 h due to the absence of a protein corona formation and low unspecific cell binding, and conjugated them with specific average numbers (2, 6, and 12) of antibodies specific for the dendritic cell (DC) surface receptor, DEC205. We assessed the time-dependent biodistribution of PB−antibody conjugates by in vivo imaging and flow cytometry. We observed that PB− antibody conjugates were trapped in the liver and that the extent of liver accumulation strongly increased with the number of attached antibodies. PB−antibody conjugates were selectively captured in the liver via Fc receptors (FcR) on liver sinusoidal endothelial cells, since systemic administration of FcR-blocking agents or the use of F(ab′) 2 fragments prevented liver accumulation. Cumulatively, our study demonstrates that liver endothelial cells play a yet scarcely acknowledged role in liver entrapment of antibody-coated NPs and that low antibody numbers on NPs and the use of F(ab′) 2 antibody fragments are both sufficient for cell type-specific targeting of secondary lymphoid organs and necessary to minimize unwanted liver accumulation.

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“…The product was purified by column chromatography. 1 H NMR (400 MHz, CDCl 3 ): 19 PB Synthesis. The synthesis was performed as described with some modifications.…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Density of Conjugated Antibody Determines the Extent of Fc Receptor Dependent Capture of Nanoparticles by Liver Sinusoidal Endothelial Cells

et al. 2021

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“…In comparison to conventional agents, drugs engineered at the nanoscale can offer a multitude of pharmacological advantages. The creation of unique and superior "Nano-drugs" is possible by fusing the extensive understanding of nanoparticles (NPs) with the most recent knowledge of cellular and molecular activities 3 . These NPs possess the remarkable ability to encapsulate, incorporate, or conjugate various drug molecules, enabling precise delivery to specific targets 3 – 5 .…”

Section: Introductionmentioning

confidence: 99%

“…The creation of unique and superior "Nano-drugs" is possible by fusing the extensive understanding of nanoparticles (NPs) with the most recent knowledge of cellular and molecular activities 3 . These NPs possess the remarkable ability to encapsulate, incorporate, or conjugate various drug molecules, enabling precise delivery to specific targets 3 – 5 . Cancer, among other devastating diseases, remains a major cause of mortality and demands urgent intervention.…”

Section: Introductionmentioning

confidence: 99%

A novel facile synthesis of metal nitride@metal oxide (BN/Gd2O3) nanocomposite and their antibacterial and anticancer activities

Mohsin,

Khashan,

Sulaiman

et al. 2023

Sci Rep

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In this study, a novel core/shell nanocomposite structure (h-BN@Gd2O3 NCs) was created for the first time by combining hexagonal boron nitride (h-BN) with doped gadolinium oxide (Gd2O3) using different laser pulse numbers, i.e., 150, 338, and 772 pulses. We employed various analytical techniques, including mapping analysis, FE-SEM, EDS, HRTEM, SAED, XRD, zeta potential analysis, DLS, FTIR, Raman spectroscopy, and PL measurements, to characterize the synthesized h-BN, c-Gd2O3, and h-BN@Gd2O3 NCs (338 pulses). XRD results indicated hexagonal and cubic crystal structures for BN and Gd2O3, respectively, while EDS confirmed their chemical composition and elemental mapping. Chemical bonds between B–N–Gd, B–N–O, and Gd–O bands at 412, 455, 474, and 520 cm−1 were identified by FTIR analysis. The antimicrobial and anticancer activities of these NCs using agar well diffusion and MTT assays. They exhibited potent antibacterial properties against both Gram-positive and Gram-negative pathogens. Furthermore, NCs have reduced the proliferation of cancerous cells, i.e., human colon adenocarcinoma cells (HT-29) and human breast cancer cells (MCF-7), while not affecting the proliferation of the normal breast cell line (MCF-10). The anticancer efficacy of NCs was validated by the AO/EtBr assay, which confirmed apoptotic cell death. Blood compatibility on human erythrocytes was also confirmed by hemolytic and in vitro toxicity assessments. The compiled results of the study proposed these nanoparticles could be used as a promising drug delivery system and potentially in healthcare applications.

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Biocidal Properties of Chitosan-Encapsulated Ternary Titanium Dioxide-Nickel Oxide-Copper Oxide Hybrid Nanomaterials Were Prepared via a Facile One-Pot Precipitation Process

et al. 2023

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Chitosan-encapsulated ternary titanium dioxide-nickel oxide-copper oxide (CTNC) hybrid nanomaterials (HNM) were synthesis via a facile one-pot precipitation method. The synthesized Chitosan-titanium dioxide-nickel oxide-copper oxide was characterized by XRD, UV, FTIR, DLS, FESEM, EDAX, and PL tested against G-(gram-negative) bacterial strain such as K. pneumonia, S. dysenteriae, E. coli, P. Vulgaris, P. aeruginosa, and V. cholerae, employed by the well method. The CTNC hybrid nanomaterials exhibit a more substantial antibacterial effect against gram-negative bacteria. The MDA-MB-231 cell-line, with an IC 50 concentration value of 9.8 g/mL was chosen to test CTNC hybrid nanomaterials' anticancer properties against human breast cancer cell lines. The toxicity studies of broblast L929 cells showed that the CTNC hybrid nanomaterials were less harmful to the healthy cells. As a result, the CTNC hybrid nanomaterials can be used for biomedical and industrial applications to improve human health conditions.

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Nanomedicine for anticancer and antimicrobial treatment: an overview

Cited by 12 publications

References 111 publications

Density of Conjugated Antibody Determines the Extent of Fc Receptor Dependent Capture of Nanoparticles by Liver Sinusoidal Endothelial Cells

Density of Conjugated Antibody Determines the Extent of Fc Receptor Dependent Capture of Nanoparticles by Liver Sinusoidal Endothelial Cells

A novel facile synthesis of metal nitride@metal oxide (BN/Gd2O3) nanocomposite and their antibacterial and anticancer activities

Biocidal Properties of Chitosan-Encapsulated Ternary Titanium Dioxide-Nickel Oxide-Copper Oxide Hybrid Nanomaterials Were Prepared via a Facile One-Pot Precipitation Process

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