2023
DOI: 10.1038/s41598-023-49895-4
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A novel facile synthesis of metal nitride@metal oxide (BN/Gd2O3) nanocomposite and their antibacterial and anticancer activities

Mayyadah H. Mohsin,
Khawla S. Khashan,
Ghassan M. Sulaiman
et al.

Abstract: In this study, a novel core/shell nanocomposite structure (h-BN@Gd2O3 NCs) was created for the first time by combining hexagonal boron nitride (h-BN) with doped gadolinium oxide (Gd2O3) using different laser pulse numbers, i.e., 150, 338, and 772 pulses. We employed various analytical techniques, including mapping analysis, FE-SEM, EDS, HRTEM, SAED, XRD, zeta potential analysis, DLS, FTIR, Raman spectroscopy, and PL measurements, to characterize the synthesized h-BN, c-Gd2O3, and h-BN@Gd2O3 NCs (338 pulses). X… Show more

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Cited by 8 publications
(2 citation statements)
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“…Interestingly, both PEG and chitosan-coated NPs exhibited a statistically significant anti-cancer effect, even in the absence of the anti-cancer drug chrysin, when compared to the negative control. The selective cytotoxicity of iron oxide NPs in cancer cells compared to normal cells is a known phenomenon, underscoring the importance of conducting further investigations to achieve a comprehensive understanding of the underlying mechanisms [56]. The mechanisms being studied extensively in this context include the enhanced permeability and retention (EPR) effect and the stimulation of magnetic hyperthermia in tumor tissues [57].…”
Section: Discussionmentioning
confidence: 99%
“…Interestingly, both PEG and chitosan-coated NPs exhibited a statistically significant anti-cancer effect, even in the absence of the anti-cancer drug chrysin, when compared to the negative control. The selective cytotoxicity of iron oxide NPs in cancer cells compared to normal cells is a known phenomenon, underscoring the importance of conducting further investigations to achieve a comprehensive understanding of the underlying mechanisms [56]. The mechanisms being studied extensively in this context include the enhanced permeability and retention (EPR) effect and the stimulation of magnetic hyperthermia in tumor tissues [57].…”
Section: Discussionmentioning
confidence: 99%
“…Cancer is a serious health concern that requires immediate attention, as it is the leading cause of death worldwide. 1 Breast cancer, in particular, continues to be a significant cause of mortality globally. 2 For the diagnosis and treatment of breast cancer, early screening, understanding disease progression mechanisms, and predicting treatment prognosis rely on rapid analysis and detection of tumor cells and their biomarkers.…”
Section: Introductionmentioning
confidence: 99%