Recent advances of nanocellulose in drug delivery systems

Hasan, Nurhasni; Rahman, Latifah; Kim, So-Hyeon; Cao, Jiafu; Arjuna, Andi; Lallo, Subehan; Jhun, Byung Hak; Yoo, Jin‐Wook

doi:10.1007/s40005-020-00499-4

Cited by 90 publications

(60 citation statements)

References 141 publications

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“…Further issues for bacterial cellulose as a drug delivery material revolve around the difficulty in modulating drug release, and irregular loading patterns of pharmaceuticals. Improved protocols and the development of novel processing techniques should be explored in order to overcome these issues which currently impede the widespread use of bacterial cellulose as a biomedical material [ 145 ].…”

Section: Limitations and Future Advancementsmentioning

confidence: 99%

Recent Advances and Applications of Bacterial Cellulose in Biomedicine

et al. 2021

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Bacterial cellulose (BC) is an extracellular polymer produced by Komagateibacter xylinus, which has been shown to possess a multitude of properties, which makes it innately useful as a next-generation biopolymer. The structure of BC is comprised of glucose monomer units polymerised by cellulose synthase in β-1-4 glucan chains which form uniaxially orientated BC fibril bundles which measure 3–8 nm in diameter. BC is chemically identical to vegetal cellulose. However, when BC is compared with other natural or synthetic analogues, it shows a much higher performance in biomedical applications, potable treatment, nano-filters and functional applications. The main reason for this superiority is due to the high level of chemical purity, nano-fibrillar matrix and crystallinity. Upon using BC as a carrier or scaffold with other materials, unique and novel characteristics can be observed, which are all relatable to the features of BC. These properties, which include high tensile strength, high water holding capabilities and microfibrillar matrices, coupled with the overall physicochemical assets of bacterial cellulose makes it an ideal candidate for further scientific research into biopolymer development. This review thoroughly explores several areas in which BC is being investigated, ranging from biomedical applications to electronic applications, with a focus on the use as a next-generation wound dressing. The purpose of this review is to consolidate and discuss the most recent advancements in the applications of bacterial cellulose, primarily in biomedicine, but also in biotechnology.

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Section: Limitations and Future Advancementsmentioning

confidence: 99%

Recent Advances and Applications of Bacterial Cellulose in Biomedicine

et al. 2021

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“…We anticipated that γCDP-(DMA/PEG-Tf) NPs with γCD pores (for host–guest interaction), pH-responsive cleavable DMA [ 22 , 23 ], and Tf (for Tf-mediated tumor endocytosis) [ 2 , 6 , 25 , 26 , 27 ] would provide a novel route for multifunctional tumor treatment [ 37 , 38 , 39 , 40 ]. Accordingly, we hypothesized that TPT drugs entrapped in the particles endocytosed to Tf-receptor positive tumor cells could be explosively released as a result of ionic repulsion between TPT and DMA-detached γCDP at endosomal pH, which in turn would enable cytosolic TPT release ( Figure 1 a).…”

Section: Resultsmentioning

confidence: 99%

Transferrin-Conjugated pH-Responsive γ-Cyclodextrin Nanoparticles for Antitumoral Topotecan Delivery

et al. 2020

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In this study, we developed γ-cyclodextrin-based multifunctional nanoparticles (NPs) for tumor-targeted therapy. The NPs were self-assembled using a γ-cyclodextrin (γCD) coupled with phenylacetic acid (PA), 2,3-dimethylmaleic anhydride (DMA), poly(ethylene glycol) (PEG), and transferrin (Tf), termed γCDP-(DMA/PEG-Tf) NPs. These γCDP-(DMA/PEG-Tf) NPs are effective in entrapping topotecan (TPT, as a model antitumor drug) resulting from the ionic interaction between pH-responsive DMA and TPT or the host–guest interaction between γCDP and TPT. More importantly, the γCDP-(DMA/PEG-Tf) NPs can induce ionic repulsion at an endosomal pH (~6.0) resulting from the chemical detachment of DMA from γCDP, which is followed by extensive TPT release. We demonstrated that γCDP-(DMA/PEG-Tf) NPs led to a significant increase in cellular uptake and MDA-MB-231 tumor cell death. In vivo animal studies using an MDA-MB-231 tumor xenografted mice model supported the finding that γCDP-(DMA/PEG-Tf) NPs are effective carriers of TPT to Tf receptor-positive MDA-MB-231 tumor cells, promoting drug uptake into the tumors through the Tf ligand-mediated endocytic pathway and increasing their toxicity due to DMA-mediated cytosolic TPT delivery.

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“…Nanocellulose has a large surface-area-to-volume ratio, thus enabling more significant adsorption and therapeutic drug-binding capacity than other materials. With these properties, nanocellulose can facilitate drug release mechanisms and allocate drug delivery precisely to the target to drastically reduce drug consumption, leading to improved drug delivery system effectiveness [ 16 , 17 ]. Nanocellulose additionally exhibits other attractive characteristics such as stiffness, high mechanical strength, biocompatibility, low toxicity, lightweight, tunable surface chemistry, and renewability [ 11 , 18 ], which are desirable for the design of advanced drug delivery system.…”

Section: Introductionmentioning

confidence: 99%

“…Nanocellulose has been manufactured on the laboratory and industrial scale, i.e., ranging from 140 g day −1 to 50 ton year −1 in three different forms as nanocrystalline cellulose (NCC), nanofiber cellulose (NFC), and bacterial nanocellulose (BNC) [ 20 ]. Several recent research and review articles have comprehensively overviewed the process, extraction, characterization, and applications of nanocellulose and their modified structures in drug delivery systems [ 12 , 17 , 21 , 22 , 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Nanocelluloses: Sources, Pretreatment, Isolations, Modification, and Its Application as the Drug Carriers

et al. 2021

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The ‘Back-to-nature’ concept has currently been adopted intensively in various industries, especially the pharmaceutical industry. In the past few decades, the overuse of synthetic chemicals has caused severe damage to the environment and ecosystem. One class of natural materials developed to substitute artificial chemicals in the pharmaceutical industries is the natural polymers, including cellulose and its derivatives. The development of nanocelluloses as nanocarriers in drug delivery systems has reached an advanced stage. Cellulose nanofiber (CNF), nanocrystal cellulose (NCC), and bacterial nanocellulose (BC) are the most common nanocellulose used as nanocarriers in drug delivery systems. Modification and functionalization using various processes and chemicals have been carried out to increase the adsorption and drug delivery performance of nanocellulose. Nanocellulose may be attached to the drug by physical interaction or chemical functionalization for covalent drug binding. Current development of nanocarrier formulations such as surfactant nanocellulose, ultra-lightweight porous materials, hydrogel, polyelectrolytes, and inorganic hybridizations has advanced to enable the construction of stimuli-responsive and specific recognition characteristics. Thus, an opportunity has emerged to develop a new generation of nanocellulose-based carriers that can modulate the drug conveyance for diverse drug characteristics. This review provides insights into selecting appropriate nanocellulose-based hybrid materials and the available modification routes to achieve satisfactory carrier performance and briefly discusses the essential criteria to achieve high-quality nanocellulose.

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Recent advances of nanocellulose in drug delivery systems

Cited by 90 publications

References 141 publications

Recent Advances and Applications of Bacterial Cellulose in Biomedicine

Recent Advances and Applications of Bacterial Cellulose in Biomedicine

Transferrin-Conjugated pH-Responsive γ-Cyclodextrin Nanoparticles for Antitumoral Topotecan Delivery

Nanocelluloses: Sources, Pretreatment, Isolations, Modification, and Its Application as the Drug Carriers

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