Recent advances of graphene–biomacromolecule nanocomposites in medical applications

Wang, Yiting; Di, Shuhan; Yu, Jianhua; Wang, Li; Li, Zhuang

doi:10.1039/d2tb01962k

Cited by 9 publications

(6 citation statements)

References 167 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Wang et al synthesized A novel zwitterionic hydrogel with incorporated graphene oxide for bone tissue engineering and found that it promotes osteogenic differentiation of BMSCs [ 174 ]. In recent years, graphene-biomacromolecule nanocomposites have also been vigorously developed in medical applications [ 175 ], which is another future direction.…”

Section: Prospectsmentioning

confidence: 99%

Progress in the application of graphene and its derivatives to osteogenesis

Guo,

Cao,

Wei

et al. 2023

Heliyon

View full text Add to dashboard Cite

Section: Prospectsmentioning

confidence: 99%

Progress in the application of graphene and its derivatives to osteogenesis

Guo,

Cao,

Wei

et al. 2023

Heliyon

View full text Add to dashboard Cite

“…Sensing components of biohybrid wearable sensors include live cells, extracellular systems (including enzymes, antibodies, and cytoskeletons), and biological macromolecules (such as nucleic acids and peptides). [ 237 ] Compared to live cells, extracellular systems and biological macromolecules offer advantages including the ease of large‐scale production and modification, enabling optimization during design and preparation to achieve higher sensitivity, specificity, and stability for use in bioreactors, detection, and molecular recognition in sensors. [ 157 , 238 ] Nevertheless, extracellular systems and biological macromolecules lack self‐replication and regeneration abilities, requiring regular replacement.…”

Section: A Path Forward For Biomimetic Wearable Sensing Systems That ...mentioning

confidence: 99%

Biomimetic Wearable Sensors: Emerging Combination of Intelligence and Electronics

Pan,

Hu,

Wang

et al. 2023

Advanced Science

View full text Add to dashboard Cite

Owing to the advancement of interdisciplinary concepts, for example, wearable electronics, bioelectronics, and intelligent sensing, during the microelectronics industrial revolution, nowadays, extensively mature wearable sensing devices have become new favorites in the noninvasive human healthcare industry. The combination of wearable sensing devices with bionics is driving frontier developments in various fields, such as personalized medical monitoring and flexible electronics, due to the superior biocompatibilities and diverse sensing mechanisms. It is noticed that the integration of desired functions into wearable device materials can be realized by grafting biomimetic intelligence. Therefore, herein, the mechanism by which biomimetic materials satisfy and further enhance system functionality is reviewed. Next, wearable artificial sensory systems that integrate biomimetic sensing into portable sensing devices are introduced, which have received significant attention from the industry owing to their novel sensing approaches and portabilities. To address the limitations encountered by important signal and data units in biomimetic wearable sensing systems, two paths forward are identified and current challenges and opportunities are presented in this field. In summary, this review provides a further comprehensive understanding of the development of biomimetic wearable sensing devices from both breadth and depth perspectives, offering valuable guidance for future research and application expansion of these devices.

show abstract

“…Support materials for enzymes include polymers and 2D materials, such as graphene and its derivatives. [2,[4][5][6] Enzymes can be immobilized on the graphene materials covalently or noncovalently, with the latter being preferred as it preserves graphene's outstanding electronic and mechanical properties. [7] The noncovalent immobilization of enzymes on graphene oxide (GO) is based on dipole-dipole and ionic interactions between the enzyme and the oxygencontaining functional groups of GO as well as 𝜋-𝜋 stacking.…”

Section: Introductionmentioning

confidence: 99%

Catalytic Activity of Horseradish Peroxidase Immobilized on Pristine and Two‐Photon Oxidized Graphene

Schirmer,

Iatta,

Emelianov

et al. 2023

Adv Materials Inter

View full text Add to dashboard Cite

Biosensors based on graphene and bio‐graphene interfaces have gained momentum in recent years due to graphene's outstanding electronic and mechanical properties. By introducing the patterning of a single‐layer graphene surface by two‐photon oxidation (2PO), the surface hydrophobicity/hydrophilicity and doping can be varied at the nanoscale while preserving the carbon network, thus opening possibilities to design new devices. In this study, the effect of 2PO on the catalytic activity of the noncovalently immobilized enzyme horseradish peroxidase (HRP) on single‐layer graphene‐coated Si/SiO2 chips is presented. To monitor the activity continuously, a simple well‐plate setup is introduced. Upon controllable 1–2‐layer immobilization, the catalytic activity decreases to a maximum value of 7.5% of the free enzyme. Interestingly, the activity decreases with increasing 2PO area on the samples. Hence, the HRP catalytic activity on the graphene surface is locally controlled. This approach can enable the development of graphene‐bio interfaces with locally varying enzyme activity.

show abstract

Recent advances of graphene–biomacromolecule nanocomposites in medical applications

Abstract: In recent years, graphene-based composites have received increasing attention due to their high biocompatibility, large specific surface area, high electrical conductivity and unique mechanical properties. The combination of biomacromolecules and...

Cited by 9 publications

References 167 publications

Progress in the application of graphene and its derivatives to osteogenesis

Progress in the application of graphene and its derivatives to osteogenesis

Biomimetic Wearable Sensors: Emerging Combination of Intelligence and Electronics

Catalytic Activity of Horseradish Peroxidase Immobilized on Pristine and Two‐Photon Oxidized Graphene

Contact Info

Product

Resources

About