Progress in the application of graphene and its derivatives to osteogenesis

Guo, Jianbin; Cao, Guihua; Wei, Song; Han, Yisheng; Xu, Peng

doi:10.1016/j.heliyon.2023.e21872

Cited by 4 publications

(2 citation statements)

References 171 publications

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“…As frequently reported in the literature, 52–55 the improvement in the cell behaviour observed for GL-coated scaffolds should be ascribed to the synergistic contribution of the surface chemistry, surface topography and roughness.…”

Section: Discussionsupporting

confidence: 56%

An integrated design strategy coupling additive manufacturing and matrix-assisted pulsed laser evaporation (MAPLE) towards the development of a new concept 3D scaffold with improved properties for tissue regeneration

Russo,

Peluso,

Gloria

et al. 2024

Nanoscale Adv.

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Section: Discussionsupporting

confidence: 56%

An integrated design strategy coupling additive manufacturing and matrix-assisted pulsed laser evaporation (MAPLE) towards the development of a new concept 3D scaffold with improved properties for tissue regeneration

Russo,

Peluso,

Gloria

et al. 2024

Nanoscale Adv.

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“…Notably, graphene oxide exhibits considerable potential in biomedical applications, attributed to its nanoscale dimensions, expansive specific surface area, exceptional mechanical strength, significant biocompatibility, elevated electrical conductivity, and antimicrobial capabilities [40,41]. Guo et al investigated the interaction of graphene and its derivatives with stem cells in different materials, demonstrating that graphene oxide accelerates the osteogenic differentiation of mesenchymal stem cells from the bone marrow [42]. Wu et al produced graphene oxide-modified β-tricalcium phosphate bioceramics, with studies indicating that an optimal amount of graphene enhances piezoelectric properties and stimulates bone formation in vivo [38].…”

Section: Introductionmentioning

confidence: 99%

Microstructure and Biocompatibility of Graphene Oxide/BCZT Composite Ceramics via Fast Hot-Pressed Sintering

Zhao,

Liu,

Tang

et al. 2024

Coatings

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Improving fracture toughness, electrical conductivity, and biocompatibility has consistently presented challenges in the development of artificial bone replacement materials. This paper presents a new strategy for creating high-performance, multifunctional composite ceramic materials by doping graphene oxide (GO), which is known to induce osteoblast differentiation and enhance cell adhesion and proliferation into barium calcium zirconate titanate (BCZT) ceramics that already exhibit good mechanical properties, piezoelectric effects, and low cytotoxicity. Using fast hot-pressed sintering under vacuum conditions, (1 − x)(Ba0.85Ca0.15Zr0.1Ti0.9)O3−xGO (0.2 mol% ≤ x ≤ 0.5 mol%) composite piezoelectric ceramics were successfully synthesized. Experimental results revealed that these composite ceramics exhibited high piezoelectric properties (d33 = 18 pC/N, kp = 62%) and microhardness (173.76 HV0.5), meeting the standards for artificial bone substitutes. Furthermore, the incorporation of graphene oxide significantly reduced the water contact angle and enhanced their wettability. Cell viability tests using Cell Counting Kit-8, alkaline phosphatase staining, and DAPI staining demonstrated that the GO/BCZT composite ceramics were non-cytotoxic and effectively promoted cell proliferation and growth, indicating excellent biocompatibility. Consequently, with their superior mechanical properties, piezoelectric performance, and biocompatibility, GO/BCZT composite ceramics show extensive potential for application in bone defect repair.

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Development of an active agar aerogel with dual antioxidant and UV-blocking activities using chlorine-doped graphene quantum dots

Taji,

Shekarchizadeh

2024

Heliyon

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Progress in the application of graphene and its derivatives to osteogenesis

Cited by 4 publications

References 171 publications

An integrated design strategy coupling additive manufacturing and matrix-assisted pulsed laser evaporation (MAPLE) towards the development of a new concept 3D scaffold with improved properties for tissue regeneration

An integrated design strategy coupling additive manufacturing and matrix-assisted pulsed laser evaporation (MAPLE) towards the development of a new concept 3D scaffold with improved properties for tissue regeneration

Microstructure and Biocompatibility of Graphene Oxide/BCZT Composite Ceramics via Fast Hot-Pressed Sintering

Development of an active agar aerogel with dual antioxidant and UV-blocking activities using chlorine-doped graphene quantum dots

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