Recent Advances of DNA Origami Technology and Its Application in Nanomaterial Preparation

Abstract

In recent years, the unrivalled self‐assembly properties of DNA molecules have driven the rapid development of a new class of DNA self‐assembly technology—DNA origami technology. Over the past decade, this technology has enabled the construction of DNA nanostructures with different shapes, such as 2D and 3D structures. Meanwhile, the application of DNA origami are also developed rapidly. DNA origami structures are widely used in nanomaterial preparation and drug delivery due to their characteristics of accurate addressability, excellent programmability, and good biocompatibility, especially in the field of nanomaterial preparation. Such structures provide a new platform to construct nanomaterials with high precision. Herein, the development of DNA origami technology is introduced, and the research progress of 2D and 3D DNA origami in the past two decades is systematically summarized. Then, the application of DNA origami template in nanomaterial preparation is emphasized. Finally, the main challenges and opportunities for nanomaterials fabrication based on DNA origami technology are illustrated.

Targeting NAD Metabolism: Rational Design, Synthesis and In Vitro Evaluation of NAMPT/PARP1 Dual-Target Inhibitors as Anti-Breast Cancer Agents

“…We hypothesize that their notable effectiveness in overcoming drug resistance results from simultaneously inhibiting NAMPT and PARP1. Subsequently, in 2021, another patent revealed compounds with the same core structure as potent NAMPT/PARP1 dual-target inhibitors (see compounds 9 ~ 10 of Figure 2 ), demonstrating strong proliferation inhibition across three breast cancer cell lines [ 21 ].…”

Cation-dependent assembly of hexagonal DNA origami lattices on SiO2 surfaces

“…7–9 Therefore, DNA origami nanostructures are currently employed in many fields of research, including biomedicine, 10 sensing, 11 electronics, 12 and materials science. 13…”

“…[7][8][9] Therefore, DNA origami nanostructures are currently employed in many fields of research, including biomedicine, 10 sensing, 11 electronics, 12 and materials science. 13 In a materials science context, the possibility to transfer the well-defined shapes of DNA origami nanostructures into organic or inorganic materials is a particularly promising approach toward nanomaterials synthesis. 14 DNA assisted lithography (DALI) is a technology that exploits DNA origami nanostructures as lithography masks in the fabrication of precisely shaped metal nanostructures on aluminum oxide or silicon nitride substrates for applications in plasmonics and optical sensing.…”

The controllable patterning of tannic acid on DNA origami

“…With the advantages of structural programmability and addressability, DNA origami structures have been widely used as templates 16 to customize various nanomaterials with predesigned patterns, including proteins, 17 metal nanoparticles, [18][19][20] quantum dots, 21 carbon nanotubes, 22 and polymers. 23 TA can interact with DNA via hydrogen bonding and has been reported to form DNA/TA hydrogels with adhesion, malleability and biodegradability, 24 as well as TA-DNA nano-complexes with controlled assembly/disassembly behaviors for drug release.…”