The controllable patterning of tannic acid on DNA origami

Luo, Yuanyuan; Niu, Liqiong; Hao, Pengyan; Sun, Xiaoya; Zhao, Yongxi; Wu, Na

doi:10.1039/d3nr04715f

Nanoscale

2023

DOI: 10.1039/d3nr04715f

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The controllable patterning of tannic acid on DNA origami

Yuanyuan Luo,

Liqiong Niu,

Pengyan Hao

et al.

Abstract: Tannic acid-based patterning is crucial to its applications in bioengineering, including multifunctional coatings, biosensors, and biochips. However, tannic acid (TA) patterning is challenging due to the rapid polymerization kinetics of...

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2024

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Polyphenol-Enabled 2D Nanopatch for Enhanced Nasal Mucoadhesion and Immune Activation

Han,

Nam,

Chung

et al. 2024

Nano Lett.

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The advancement of effective nasal mucoadhesive delivery faces challenges due to rapid mucociliary clearance (MCC). Conventional studies have employed mucoadhesive materials, mainly forming spherical nanoparticles, but these offer limited adhesion to the nasal mucosa. This study hypothesizes that a 2D nanoscale structure utilizing adhesive polyphenols can provide a superior strategy for countering MCC, aligning with the planar mucosal layers. We explore the use of tannic acid (TA), a polyphenolic molecule known for its adhesive properties and ability to form complexes with biomolecules. Our study introduces an unprecedented 2D nanopatch, assembled through the interaction of TA with green fluorescent protein (GFP), and cell-penetrating peptide (CPP). This 2D nanopatch demonstrates robust adhesion to nasal mucosa and significantly enhances immunoglobulin A secretions, suggesting its potential for enhancing nasal vaccine delivery. The promise of a polyphenol-enabled adhesive 2D nanopatch signifies a pivotal shift from conventional spherical nanoparticles, opening new pathways for delivery strategies through respiratory mucoadhesion.

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Polyphenol-Enabled 2D Nanopatch for Enhanced Nasal Mucoadhesion and Immune Activation

Han,

Nam,

Chung

et al. 2024

Nano Lett.

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show abstract

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The controllable patterning of tannic acid on DNA origami

Abstract: Tannic acid-based patterning is crucial to its applications in bioengineering, including multifunctional coatings, biosensors, and biochips. However, tannic acid (TA) patterning is challenging due to the rapid polymerization kinetics of...

Cited by 1 publication

References 33 publications

Polyphenol-Enabled 2D Nanopatch for Enhanced Nasal Mucoadhesion and Immune Activation

Polyphenol-Enabled 2D Nanopatch for Enhanced Nasal Mucoadhesion and Immune Activation

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