Recent advances of chitosan composites in artificial skin: the next era for potential biomedical application

Sharma, S. N.; Batra, Sonali

doi:10.1016/b978-0-12-816909-4.00005-1

Cited by 21 publications

(12 citation statements)

References 45 publications

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“…In the wound healing process, fibroblasts and capillaries must invade the clot to form a contractile granulation tissue that can draw the wound margins together [10]. Chitosan molecules also play a crucial role in healing by facilitating cell growth and proliferation as well as organizing the deposition of collagen [15,106]. Additionally, earlier observations showed that the combination of collagen and chitosan acts as a supportive scaffold for all growth factors producing cells, inducing faster tissue organization and regeneration [99,107].…”

Section: Masson's Trichrome Stainmentioning

confidence: 99%

Glibenclamide Nanocrystal-Loaded Bioactive Polymeric Scaffolds for Skin Regeneration: In Vitro Characterization and Preclinical Evaluation

et al. 2021

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Skin restoration following full-thickness injury poses significant clinical challenges including inflammation and scarring. Medicated scaffolds formulated from natural bioactive polymers present an attractive platform for promoting wound healing. Glibenclamide was formulated in collagen/chitosan composite scaffolds to fulfill this aim. Glibenclamide was forged into nanocrystals with optimized colloidal properties (particle size of 352.2 nm, and polydispersity index of 0.29) using Kolliphor as a stabilizer to allow loading into the hydrophilic polymeric matrix. Scaffolds were prepared by the freeze drying method using different total polymer contents (3–6%) and collagen/chitosan ratios (0.25–2). A total polymer content of 3% at a collagen/chitosan ratio of 2:1 (SCGL3-2) was selected based on the results of in vitro characterization including the swelling index (1095.21), porosity (94.08%), mechanical strength, rate of degradation and in vitro drug release. SCGL3-2 was shown to be hemocompatible based on the results of protein binding, blood clotting and percentage hemolysis assays. In vitro cell culture studies on HSF cells demonstrated the biocompatibility of nanocrystals and SCGL3-2. In vivo studies on a rat model of a full-thickness wound presented rapid closure with enhanced histological and immunohistochemical parameters, revealing the success of the scaffold in reducing inflammation and promoting wound healing without scar formation. Hence, SCGL3-2 could be considered a potential dermal substitute for skin regeneration.

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Section: Masson's Trichrome Stainmentioning

confidence: 99%

Glibenclamide Nanocrystal-Loaded Bioactive Polymeric Scaffolds for Skin Regeneration: In Vitro Characterization and Preclinical Evaluation

et al. 2021

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“…In recent decades, several natural and synthetic polymers have been used for wound healing such as CS [122,123], gelatin [124,125], hyaluronic acid [126], and poly vinyl alcohol [127]. Among these polymers, CSs are extensively being employed as skin regeneration components in dermal TE because of the property of hemostasis which improves tissue reproduction and induces collagen formation of fibroblasts and antibacterial activity [128][129][130][131][132][133][134][135][136]. CS in the shape of cotton fiber could improve wound healing by escalating the penetration rate of polymorphonuclear (PMN) cells at the wound site.…”

Section: Skin Regenerationmentioning

confidence: 99%

“…Due to the fact that clinical purposes of cell-based approaches are restricted as a result of the expense of keeping cellular constructs on the shelf, possible immune reaction to allogeneic cell lines, and scarce tissue, these acellular scaffolds which may stimulate endogenous influx and uniform distribution of native stem cells from bone marrow could be great candidate for cartilage reproduction [ 109 ]. In this connection, chitosan based constructs have been used for soft tissue regeneration frequently [ 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , 148 , 149 , 150 , 151 , 152 , 153 , 154 , …”

Section: Chitosan-based 3d Printed Construct For Hard Tissues Applmentioning

confidence: 99%

Three-Dimensional Printing Constructs Based on the Chitosan for Tissue Regeneration: State of the Art, Developing Directions and Prospect Trends

et al. 2020

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Chitosan (CS) has gained particular attention in biomedical applications due to its biocompatibility, antibacterial feature, and biodegradability. Hence, many studies have focused on the manufacturing of CS films, scaffolds, particulate, and inks via different production methods. Nowadays, with the possibility of the precise adjustment of porosity size and shape, fiber size, suitable interconnectivity of pores, and creation of patient-specific constructs, 3D printing has overcome the limitations of many traditional manufacturing methods. Therefore, the fabrication of 3D printed CS scaffolds can lead to promising advances in tissue engineering and regenerative medicine. A review of additive manufacturing types, CS-based printed constructs, their usages as biomaterials, advantages, and drawbacks can open doors to optimize CS-based constructions for biomedical applications. The latest technological issues and upcoming capabilities of 3D printing with CS-based biopolymers for different applications are also discussed. This review article will act as a roadmap aiming to investigate chitosan as a new feedstock concerning various 3D printing approaches which may be employed in biomedical fields. In fact, the combination of 3D printing and CS-based biopolymers is extremely appealing particularly with regard to certain clinical purposes. Complications of 3D printing coupled with the challenges associated with materials should be recognized to help make this method feasible for wider clinical requirements. This strategy is currently gaining substantial attention in terms of several industrial biomedical products. In this review, the key 3D printing approaches along with revealing historical background are initially presented, and ultimately, the applications of different 3D printing techniques for fabricating chitosan constructs will be discussed. The recognition of essential complications and technical problems related to numerous 3D printing techniques and CS-based biopolymer choices according to clinical requirements is crucial. A comprehensive investigation will be required to encounter those challenges and to completely understand the possibilities of 3D printing in the foreseeable future.

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“…Publications from the last 10 years containing the terms "chitosan", "gastroretentive" and "drug delivery". medical products, cosmetics and mainly, in pharmaceutical applications [23][24][25][26].…”

Section: Chitin and Chitosanmentioning

confidence: 99%

Highlighting the impact of chitosan on the development of gastroretentive drug delivery systems

Souza

Sábio

Ribeiro

et al. 2020

International Journal of Biological Macromolecules

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The development of gastroretentive systems have been growing lately due to the high demand for carriers that increase drug bioavailability and therapeutic effectiveness after oral administration. Most of systems reported up to now are based on chitosan (CS) due to its peculiar properties, such as cationic nature, biodegradability, biocompatibility and important mucoadhesiveness, which make CS a promising biopolymer to design effective gastroretentive systems. In light of this, we reported in this review the CS versatility to fabricate different types of nano-and microstructured gastroretentive systems. For a better understanding of the gastric retention mechanisms, we highlighted expandable, density-based, magnetic, mucoadhesive and superporous systems. The biological and chemical properties of CS, anatomophysiological aspects related to gastrointestinal tract (GIT) and some applications of these systems are also described here. Overall, this review may assist researchers to explore new strategies to design safe and efficient gastroretentive systems in order to popularize them in the treatment of diseases and clinical practices.

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Recent advances of chitosan composites in artificial skin: the next era for potential biomedical application

Cited by 21 publications

References 45 publications

Glibenclamide Nanocrystal-Loaded Bioactive Polymeric Scaffolds for Skin Regeneration: In Vitro Characterization and Preclinical Evaluation

Glibenclamide Nanocrystal-Loaded Bioactive Polymeric Scaffolds for Skin Regeneration: In Vitro Characterization and Preclinical Evaluation

Three-Dimensional Printing Constructs Based on the Chitosan for Tissue Regeneration: State of the Art, Developing Directions and Prospect Trends

Highlighting the impact of chitosan on the development of gastroretentive drug delivery systems

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