Recent advances in understanding acute respiratory distress syndrome

Wohlrab, Peter; Kraft, Felix; Tretter, Verena; Ullrich, Robert C.; Markstaller, Klaus; Klein, Klaus Ulrich

doi:10.12688/f1000research.11148.1

Cited by 21 publications

(20 citation statements)

References 98 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The major immune cells involved in ARDS are neutrophils, macrophages, lymphocytes, and platelets ( Fanelli et al., 2013 ; Butt et al., 2016 ; Confalonieri et al., 2017 ). The pathogenesis of sepsis and ARDS is closely related to the aberrant activation of inflammatory responses, which play a key role in the development of ARDS ( Wohlrab et al., 2015 ).…”

Section: Discussionmentioning

confidence: 99%

Alleviation of Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome in Rats by Yiqi Huayu Jiedu Decoction: A Tandem Mass Tag-Based Proteomics Study

Luo

et al. 2020

Front. Pharmacol.

View full text Add to dashboard Cite

Background To study the effect of Yiqi Huayu Jiedu Decoction (YQHYJD) on protein expression in the lung tissue of acute respiratory distress syndrome (ARDS) rats and to explore the underlying molecular therapeutic mechanism of YQHYJD. Methods Sprague Dawley rats were administered with YQHYJD by oral gavage for 1 week. The rats were injected with lipopolysaccharide (LPS) to induce ARDS. The lung injury was assessed pathologically. Differentially expressed proteins (DEPs) were screened by quantitative proteomics and analyzed using bioinformatic tools, such as Metascape and Kyoto Encyclopedia of Genes and Genomes (KEGG) mapper. DEPs were verified by parallel reaction monitoring (PRM). Results YQHYJD alleviated the LPS-induced pathological damage of lung tissue in rats. There were 134 DEPs among the YQHYJD treatment and model groups. The Genomes pathway analyses revealed that the DEPs were closely related to immune system pathway. The mass spectrometry analysis revealed that YQHYJD exhibits a protective effect on lung tissue by significantly upregulating hematopoietic cell kinase (Hck), phospholipid phosphatase 3 (Plpp3), myristoylated-alanine rich C-kinase substrate (Marcks), and Actin-related protein 2/3 complex subunit 2 (Arpc2), which are related to Fc gamma receptor-mediated phagocytosis pathway. Conclusion YQHYJD can alleviate the lung injury of ARDS rats by regulating the Fc gamma receptor-mediated phagocytosis pathway, which is related to immune system.

show abstract

Section: Discussionmentioning

confidence: 99%

Alleviation of Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome in Rats by Yiqi Huayu Jiedu Decoction: A Tandem Mass Tag-Based Proteomics Study

Luo

et al. 2020

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…Release of pro-inflammatory cytokines, such as Tumor Necrosis Factor alpha (TNF-α), interleukin 1 beta (IL-1β), interleukin 6 (IL-6), and interleukin 8 (IL-8) which in turn recruit components of the innate immune system have been shown to be associated with ARDS [34,35]. Neutrophils are recruited to the lungs by these cytokines, which then become activated and release toxic mediators [36], leading to extensive free radical production and reactive oxygen species which overwhelms endogenous anti-oxidants resulting in oxidative cell damage to lung tissue [37].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of glutathione therapy in relieving dyspnea associated with COVID-19 pneumonia: A report of 2 cases

Horowitz¹,

Freeman²,

Bruzzese

2020

Respiratory Medicine Case Reports

158

156

View full text Add to dashboard Cite

“…30,37 Then, the protein-rich fluid induces acute pulmonary edema and inactivates PS. 36 In addition, the inflammatory reaction damages alveolar type II cells and decreases the quantity of PS synthesized; Figure 1A. The relationship between the age at which the MDR-KP infection was acquired and gestational age.…”

Section: Discussionmentioning

confidence: 99%

Differences in clinical characteristics of early- and late-onset neonatal sepsis caused by Klebsiella pneumoniae

You

Zhang

Ling

et al. 2020

Int J Immunopathol Pharmacol

View full text Add to dashboard Cite

To identify differences in the clinical characteristics of early- and late-onset sepsis (EOS and LOS) caused by Klebsiella pneumoniae ( K. pneumoniae) and to describe the risk factors for multidrug-resistant K. pneumoniae (MDR-KP) infection. Infants with K. pneumoniae-induced sepsis who were admitted to a children’s Hospital between Jan 2000 and Dec 2019 were included. All infants were divided into EOS and LOS groups, as well as MDR-KP and non-MDR-KP groups. Demographics, clinical characteristics, and risk factors were compared between the two groups. One hundred eighty infants (66 with EOS and 114 with LOS) were further analyzed, accounting for 36.8% of sepsis cases caused by MDR-KP. The frequency of respiratory failure, bronchopulmonary dysplasia, and intraventricular hemorrhage were more common in the LOS group and a higher rate of acute respiratory distress syndrome was more common in infants in the EOS group ( P < 0.05). K. pneumoniae showed a low sensitivity to penicillin, beta-lactams and cephalosporins, and it showed a high sensitivity to levofloxacin, ciprofloxacin, and amikacin. Prematurity, low birth weight, longer antibiotic exposure time, long duration of peripheral catheter insertion, long mechanical ventilation time, and long parenteral nutrition time were associated with an increased rate of MDR-KP infection by univariate analysis ( P < 0.05). The regression analysis identified a long antibiotic exposure time (OR = 1.37, 95% CI: 1.01–1.89) and long parenteral nutrition time (OR = 1.39, 95% CI: 1.01–1.89) as independent risk factors for a MDR-KP infection, and a greater gestational age and birth weight were associated with a lower risk of MDR-KP infection (OR = 0.57, 95% CI: 0.40–0.79). LOS caused by K. pneumoniae may lead to a higher frequency of complications. The risk factors for MDR-KP infection were longer duration of antibiotic exposure and parenteral nutrition. A greater gestational age and larger birth weight may decrease the risk of MDR-KP infection.

show abstract

Recent advances in understanding acute respiratory distress syndrome

Cited by 21 publications

References 98 publications

Alleviation of Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome in Rats by Yiqi Huayu Jiedu Decoction: A Tandem Mass Tag-Based Proteomics Study

Alleviation of Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome in Rats by Yiqi Huayu Jiedu Decoction: A Tandem Mass Tag-Based Proteomics Study

Efficacy of glutathione therapy in relieving dyspnea associated with COVID-19 pneumonia: A report of 2 cases

Differences in clinical characteristics of early- and late-onset neonatal sepsis caused by Klebsiella pneumoniae

Contact Info

Product

Resources

About