Recent advances in thermo-sensitive hydrogels for drug delivery

Abstract

Thermo-sensitive hydrogels based on different polymers have been broadly used in the pharmaceutical fields. In this review, the state-of-the-art thermo-sensitive hydrogels for drug delivery are elaborated

Recent near-infrared light-activated nanomedicine toward precision cancer therapy

“…With the potential to serve as thermoresponsive gating materials, wax materials are referred to as fatty acid analog phase-change materials (PCMs) which enveloped drugs in the hydrophobic region for photothermal controlled release. 223,224 Xia's group also prepared a nano-eutectic mixture with a melting point at 39 1C by using naturally occurring fatty acids (lauric acid and stearic acid in this report) with remarkable biocompatibility and biodegradability. 225 After encapsulating DOX and IR780 iodide (IR780, a NIR-absorbing dye), the nanoparticles were decorated with lecithin and DSPE-PEG5000 and exhibited NIR-light responsivity for drug delivery.…”

Biomedical Application, Patent Repository, Clinical Trial and Regulatory Updates on Hydrogel: An Extensive Review

“…They have the ability to undergo phase transition or swell/deswell at ambient alteration of temperature. Concentrate solution of poloxamer with water is one good example of thermoreversible gel widely used for tissue engineering applications nowadays [13,14]. Further, the rate and degree of swelling, controls the release patterns of drugs and solvents from hydrogel polymeric networks.…”

Design and Applications of Tumor Microenvironment-Responsive Nanogels as Drug Carriers

“…Another feature of tumors and inflammatory areas is that the temperature (40-45 °C) is slightly higher than that (37 °C) of body fluids, which makes it valuable to design thermo-sensitive nanogels (Seo et al, 2012). Changes in temperature can reverse the segment-segment interaction or the segmentsolvent molecule interaction, resulting in swelling or shrinkage of nanogels to achieve responsive drug release with corresponding temperature of the lower and higher critical solution temperature (LCST/UCST) (Yu et al, 2021).…”

“…Compared with PNIPAM-based nanogels, polypyrrole-based nanogels can be accumulated in multiple intravenous injections without structural collapse at higher temperatures (such as 37 °C). Besides, polymers with thermo-sensitivity, such as polyethylene glycol, polyethylene oxide-polypropylene oxide copolymers, poly (ε-caprolactone), and poly (propylene glycol) are also expected to be applied to design temperature-dependent nanogels for drug delivery (Yu et al, 2021).…”