Recent advances in theranostic polymeric nanoparticles for cancer treatment: A review

Indoria, Shikha; Singh, Vickramjeet; Hsieh, Ming‐Fa

doi:10.1016/j.ijpharm.2020.119314

Cited by 127 publications

(62 citation statements)

References 170 publications

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“…Moreover, combinatorial therapy with Bcl-2 and PKC-iota siRNAs loaded into the anti-EGFR QLs was said to be remarkably effective in inhibiting tumor growth and metastasis, leading to the conclusion that these anti-EGFR aptamer-guided lipid carriers may be a potential theranostic delivery vehicle for RNA interference and fluorescence imaging of TNBCs. For a 2020 review of recent advances in theranostic polymeric nanoparticles for cancer treatment, see Indoria et al [ 20 ].…”

Section: Targeted Deliverymentioning

confidence: 99%

Recent advances in aptamer applications for analytical biochemistry

Zon

2022

Analytical Biochemistry

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Aptamers are typically defined as relatively short (20–60 nucleotides) single-stranded DNA or RNA molecules that bind with high affinity and specificity to various types of targets. Aptamers are frequently referred to as “synthetic antibodies” but are easier to obtain, less expensive to produce, and in several ways more versatile than antibodies. The beginnings of aptamers date back to 1990, and since then there has been a continual increase in aptamer publications. The intent of the present account was to focus on recent original research publications, i.e., those appearing in 2019 through April 2020, when this account was written. A Google Scholar search of this recent literature was performed for relevance-ranking of articles. New methods for selection of aptamers were not included. Nine categories of applications were organized and representative examples of each are given. Finally, an outlook is offered focusing on “faster, better, cheaper” application performance factors as key drivers for future innovations in aptamer applications.

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Section: Targeted Deliverymentioning

confidence: 99%

Recent advances in aptamer applications for analytical biochemistry

Zon

2022

Analytical Biochemistry

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“…In addition, these systems usually range in size from several tens of nanometers to 100-200 nm, which, nevertheless, suggests the multimolecular nature of colloidal particles. Monomolecular micellar nanosized preparations based on Boltorn-PCL modified with PEG and malic acid were obtained [125]. Some PEG blocks were modified with folic acid, and DOX was conjugated through pH-sensitive hydrazone bonds which were cleaved in an acidic medium [125].…”

Section: Branched Polymers Based On Boltorn Polyestersmentioning

confidence: 99%

Linear and Branched Lactide Polymers for Targeted Drug Delivery Systems

et al. 2021

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“…This thermosensitive polymeric system released the loaded drug due to increase in temperature which was facilitated by externally applied magnetic field 33 . Magnetic nanostructures have been developed as theranostic agents who provide dual function of diagnostic and therapeutic agents for diagnosis and treatment of cancers like medulloblastoma and Alzheimer's disease 34 .…”

Section: Superparamagnetic Npsmentioning

confidence: 99%

Exploring Recent Advances in Nanotherapeutics

Rao¹,

Sonawane²,

Sapate³

et al. 2020

J. Drug Delivery Ther.

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Nanotechnology is a rapidly expanding field, encompassing the development of materials in a size range of 5-200 nanometers (nm). The applications of nanotechnology to drug delivery opened the floodgates to create novel therapeutics and diagnostics which have changed the landscape of pharmaceutical and biotechnological industries. Advances in nanotechnology are being utilized in medicine for therapeutic drug delivery and treatment of various diseases and disorders. The biodegradable nanoparticle/nanocarriers, in which drug is dissolved and entrapped are specially designed to absorb the drug and to protect it against chemical and enzymatic degradation. The important role to design these nanostructures as a delivery system is to release pharmacologically active molecules for site-specific action with an accurate dose. In recent times, several biodegradable polymeric nanostructures have been developed with an innate capacity to target specific organs/tissue to deliver the drug. Nanoparticulate drug delivery systems use polymers or lipids as carriers for drugs. Newer polymers engineered to achieve temporal and spatial drug delivery form the mainstay of these systems. In nanotechnology, being tiny molecules of immunotherapeutic have many advantages over biological drugs regarding complexity, tissue penetration, manufacturing cost, stability and shelf life, which is one of dominating therapy in the current research field. The present review gives details about the recent developments of nanostructure drug delivery systems and their applications. Keywords: liposomes, polymeric micelles, gold nanoparticles, superparamagnetic nanoparticles, solid lipid nanoparticles, aptamers, quantum dots.

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Recent advances in theranostic polymeric nanoparticles for cancer treatment: A review

Cited by 127 publications

References 170 publications

Recent advances in aptamer applications for analytical biochemistry

Recent advances in aptamer applications for analytical biochemistry

Linear and Branched Lactide Polymers for Targeted Drug Delivery Systems

Exploring Recent Advances in Nanotherapeutics

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