Linear and Branched Lactide Polymers for Targeted Drug Delivery Systems

Gomzyak, V. I.; Sedush, Nikita G.; Пучков, А. А.; Polyakov, D. K.; Чвалун, С. Н.

doi:10.1134/s1560090421030064

Cited by 20 publications

(7 citation statements)

References 126 publications

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“…12,13 PLA and PLGA exhibit high biocompatibility, biodegradability and nontoxicity, which are distinct advantages for biomedical applications. 14 PEG has been widely used as a hydrophilic segment for the preparation of amphiphilic star BCPs, because it is soluble in both water and organic solvents and exhibits excellent biocompatibility and nontoxicity. 13 In this context, poly((oligoethylene glycol) methyl ether acrylate) (POEOA), a water-soluble polymer, is an interesting alternative for the formation of hydrophilic domains of amphiphilic star BCPs.…”

Section: Introductionmentioning

confidence: 99%

Novel degradable amphiphilic 4-arm star PLA-b-POEOA and PLGA-b-POEOA block copolymers: synthesis, characterization and self-assembly

et al. 2023

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Section: Introductionmentioning

confidence: 99%

Novel degradable amphiphilic 4-arm star PLA-b-POEOA and PLGA-b-POEOA block copolymers: synthesis, characterization and self-assembly

et al. 2023

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“…To mimic in vivo degradation conditions, we initially examined the degradation dynamics of PLGA in vitro. PLGA, a linear copolymer with adjustable constituent monomers, lactic (L) and glycolic (G) acid 41 ( Fig. 2B ), underwent incubation at 37 °C and 55 °C as an accelerated condition for 7 days.…”

Section: Resultsmentioning

confidence: 99%

Biologically Driven In Vivo Occlusion Design Provides a Reliable Experimental Glaucoma Model

Hong,

Tian,

Glynn

et al. 2024

Preprint

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Fluid flow transport through the trabecular meshwork tissues is a major regulator of intraocular pressure (IOP) modulation in healthy and glaucomatous individuals. Microbead occlusion models of ocular hypertension regulate aqueous humor drainage to induce high IOP to allow for in vivo study of pressure-related glaucomatous pathology. However, the reliability and application of current injectable microbeads are hindered by inadequate design of the beads-tissue interfaces to maintain a stable IOP elevation over the long term. Considering the graded, porous architecture and fluid transport of the trabecular meshwork, we developed a tailored, injectable viscobeads technique, which induced a sustained elevation of IOP for at least 8 weeks. These composite viscobeads contain a non-degradable polystyrene (PS) core for structural support and a biodegradable polylactic-co-glycolic acid (PLGA) viscoelastic surface. This approach enhances the obstruction of aqueous humor drainage through heterogeneous sizes of trabecular meshwork fenestrations and reliably modulates the magnitude and duration of ocular hypertension. In a mouse model, a single viscobeads injection resulted in sustained IOP elevation (average 21.4+-1.39 mm Hg), leading to a 34% retinal ganglion cell (RGC) loss by 56 days. In an earlier stage of glaucoma progression, we conducted non-invasive electroretinography (ERG) recording and revealed glaucomatous progression by analyzing high-frequency oscillatory potentials. To further explore the application of the viscobeads glaucoma models, we assayed a series of genes through adeno-associated virus (AAV)-mediated screening in mice and assessed the impact of genetic manipulation on RGC survivals. CRISPR mediated disruption of the genes, PTEN, ATF3 and CHOP enhanced RGC survival while LIN 28 disruption negatively impacted RGC survival. This biologically driven viscobeads design provides an accessible approach to investigate chronic intraocular hypertension and glaucoma-like neurodegeneration and ultimately tenders the opportunity to evaluate genetic and pharmacological therapeutics.

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“…In recent years, many biodegradable polymer-based microspheres have been utilized as vehicles for drug delivery ( 125 , 126 ). The variety of these systems is varied in sizes in the range of hundreds of nanometers to 10 μm and can be generated from various polymers, such as poly(glycolic acid) (PGA), poly(lactic acid) (PLA), or their copolymer, poly(lactic-co-glycolic acid).…”

Section: Different Immunotherapies and Polymeric Systems Applying For...mentioning

confidence: 99%

Polymeric Systems for Cancer Immunotherapy: A Review

Le¹,

Yoon²,

Thambi³

et al. 2022

Front. Immunol.

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Immunotherapy holds enormous promise to create a new outlook of cancer therapy by eliminating tumors via activation of the immune system. In immunotherapy, polymeric systems play a significant role in improving antitumor efficacy and safety profile. Polymeric systems possess many favorable properties, including magnificent biocompatibility and biodegradability, structural and component diversity, easy and controllable fabrication, and high loading capacity for immune-related substances. These properties allow polymeric systems to perform multiple functions in immunotherapy, such as immune stimulants, modifying and activating T cells, delivery system for immune cargos, or as an artificial antigen-presenting cell. Among diverse immunotherapies, immune checkpoint inhibitors, chimeric antigen receptor (CAR) T cell, and oncolytic virus recently have been dramatically investigated for their remarkable success in clinical trials. In this report, we review the monotherapy status of immune checkpoint inhibitors, CAR-T cell, and oncolytic virus, and their current combination strategies with diverse polymeric systems.

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Linear and Branched Lactide Polymers for Targeted Drug Delivery Systems

Abstract: The review presents modern advances in the synthesis of biodegradable polymers based on lactide of various topologies and also analyzes the main methods for preparation of nanoparticles that show promise for the creation of targeted drug delivery systems.

Cited by 20 publications

References 126 publications

Novel degradable amphiphilic 4-arm star PLA-b-POEOA and PLGA-b-POEOA block copolymers: synthesis, characterization and self-assembly

Novel degradable amphiphilic 4-arm star PLA-b-POEOA and PLGA-b-POEOA block copolymers: synthesis, characterization and self-assembly

Biologically Driven In Vivo Occlusion Design Provides a Reliable Experimental Glaucoma Model

Polymeric Systems for Cancer Immunotherapy: A Review

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