Novel degradable amphiphilic 4-arm star PLA-<i>b</i>-POEOA and PLGA-<i>b</i>-POEOA block copolymers: synthesis, characterization and self-assembly

Oliveira, Andreia S. R.; Pereira, Patrícia; Mendonça, Patrícia V.; Fonseca, A. C.; Simões, Sérgio; Serra, Arménio C.; Coelho, Jorge F. J.

doi:10.1039/d2py01216b

Cited by 6 publications

(9 citation statements)

References 43 publications

(68 reference statements)

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“…Recent work combines PLA and poly[(oligoethylene glycol) methyl ether acrylate] (POEOA) to generate stars, as shown in Fig. 18 128 . Stars have been found to be particularly good at forming micelles and core−shell structures with small hydrodynamic volumes and unique spherical structures, and demonstrate a good functionality at their surfaces compared to linear block copolymers.…”

Section: Block Copolymers From Plamentioning

confidence: 99%

“…Ring‐opening polymerization (ROP) and atom transfer radical polymerization (ATRP) used to prepare amphiphilic 4‐ star ‐PLA‐ block ‐poly[(oligoethylene glycol) methyl ether acrylate] copolymers. Reproduced with permission from the RSC 128 …”

Section: Block Copolymers From Plamentioning

confidence: 99%

“…18. 128 Stars have been found to be particularly good at forming micelles and core−shell structures with small hydrodynamic volumes and unique spherical structures, and demonstrate a good functionality at their surfaces compared to linear block copolymers. In their work, Oliveira et al use ATRP but, conscious that the copper catalyst is toxic with respect to drug delivery at regular concentrations (>20 000 ppm), they have used continuous activator regeneration (ICAR) to rejuvenate the metal in ATRP, and hence reduce the metal down to an extraordinarily low 1070 ppm!…”

Section: Block Copolymers From Plamentioning

confidence: 99%

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Review: Syntheses of poly(lactic acid)s and their block copolymers for drug delivery applications

Oktavia

Bégué

Campana

et al. 2023

Polymer International

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Since the advent of supporting matrices for biological applications, many types of drugs have been administered via various forms of conventional drug delivery preparations, such as pills, solutions, creams, suppositories, injected gels and so on. Key parameters to all these systems for effective drug delivery are controlled release for sustained periods, targeted delivery, and enhancements of drug stability and efficacy, all of which can be manipulated by using polymers. Given the important impact of the structures of the polymers on these parameters, this mini‐review gives a simple introduction to the requirements of drug delivery systems and surveys the synthetic pathways to a key polymer in this field, namely poly(lactic acid). We also review the preparation of block copolymers that incorporate poly(lactic acid), to expand and further develop its properties for drug delivery systems. It is hoped that this short teacherly and introductory review will provide a basic stepping‐stone to more in‐depth reviews and papers and enable an easy access to this fast growing field. © 2023 Society of Industrial Chemistry.

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Section: Block Copolymers From Plamentioning

confidence: 99%

Section: Block Copolymers From Plamentioning

confidence: 99%

Section: Block Copolymers From Plamentioning

confidence: 99%

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Review: Syntheses of poly(lactic acid)s and their block copolymers for drug delivery applications

Oktavia

Bégué

Campana

et al. 2023

Polymer International

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“…[1][2][3][4][5][6][7][8][9][10] In order to optimize their aforementioned properties for this range of applications, the role of polymer constitution and topology has been widely explored, with a range of architectures including homopolymers, block copolymers, branched and ring polymers. [11][12][13][14][15][16][17] As a result of contemporary research activities, the chemical and structural domains of synthetic polymers are continuously growing. [18][19][20] Polymeric materials have been the focus of a significant amount of scientific research for many decades.…”

Section: Introductionmentioning

confidence: 99%

Modular Software for Generating and Modelling Diverse Polymer Databases

Santana‐Bonilla

Castro

Sun

et al. 2023

Preprint

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Machine learning methods offer the opportunity to design new functional materials on an unprecedented scale however building the large, diverse databases of molecules on which to train such methods remains a daunting task. Automated computational chemistry modelling workflows are therefore becoming essential tools in this data-driven hunt for new materials with novel properties, since they offer a workflow by which to create and curate molecular databases without requiring significant levels of user input. This ensures well-founded concerns regarding data provenance, reproducibility and replicability are mitigated. We have developed a versatile and flexible software package, PySoftK (Python Soft Matter at King's College London), that provides flexible, automated computational workflows to create, model, and curate libraries of polymers with a minimal user intervention. PySoftK is available as an efficient, fully-tested, and easily installed Python package. Key features of the software include the wide range of different polymer topologies that can be automatically generated and fully parallelized library generation tools. It is anticipated that PySoftK will support the generation, modelling and curation of large polymer libraries to support functional materials discovery in nano- and bio-technology.

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“…The diverse chemical, mechanical, and electronic properties of polymers underlie their application in relevant technological areas spanning structural materials, cosmetics, pharmaceutical formulation, electronics, and biotechnology. − In order to optimize their aforementioned properties for this range of applications, the roles of polymer constitution and topology have been widely explored, with a range of architectures including homopolymers, block copolymers, and branched and ring polymers. − As a result of contemporary research activities, the chemical and structural domains of synthetic polymers are continuously growing. − …”

Section: Introductionmentioning

confidence: 99%

Modular Software for Generating and Modeling Diverse Polymer Databases

Santana‐Bonilla

Castro

Sun

et al. 2023

J. Chem. Inf. Model.

View full text Add to dashboard Cite

Machine learning methods offer the opportunity to design new functional materials on an unprecedented scale; however, building the large, diverse databases of molecules on which to train such methods remains a daunting task. Automated computational chemistry modeling workflows are therefore becoming essential tools in this data-driven hunt for new materials with novel properties, since they offer a means by which to create and curate molecular databases without requiring significant levels of user input. This ensures that well-founded concerns regarding data provenance, reproducibility, and replicability are mitigated. We have developed a versatile and flexible software package, PySoftK (Python Soft Matter at King’s College London) that provides flexible, automated computational workflows to create, model, and curate libraries of polymers with minimal user intervention. PySoftK is available as an efficient, fully tested, and easily installable Python package. Key features of the software include the wide range of different polymer topologies that can be automatically generated and its fully parallelized library generation tools. It is anticipated that PySoftK will support the generation, modeling, and curation of large polymer libraries to support functional materials discovery in the nanotechnology and biotechnology arenas.

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Novel degradable amphiphilic 4-arm star PLA-b-POEOA and PLGA-b-POEOA block copolymers: synthesis, characterization and self-assembly

Abstract: Well-defined amphiphilic biodegradable block copolymers (BCPs) are promising materials as drug/gene carriers because they can self-assemble in aqueous medium and form various nanostructures. In this work, conditions were developed for...

Cited by 6 publications

References 43 publications

Review: Syntheses of poly(lactic acid)s and their block copolymers for drug delivery applications

Review: Syntheses of poly(lactic acid)s and their block copolymers for drug delivery applications

Modular Software for Generating and Modelling Diverse Polymer Databases

Modular Software for Generating and Modeling Diverse Polymer Databases

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