Recent Advances in The Use of Magnetic Nanoparticles to Promote Neuroregeneration

Falconieri, Alessandro; Vincentiis, Sara De; Raffa, Vittoria

doi:10.2217/nnm-2019-0103

Cited by 19 publications

(12 citation statements)

References 20 publications

(19 reference statements)

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“…We did not quantify this effect in detail, but it is easily observable within the Supplementary Videos S3 , S4 , S5 , S6 , S7 , and S8 . Such behaviour might be of great relevance for applications where cells should be linearly aligned to form barriers or scaffolds (eg, to direct the growth of capillary or nerve cells in certain directions 24 ). By comparing Figure 2A (cells before the magnetic fields were applied) with Figure 2D (cells after the application), it can be shown that this aggregation behaviour is reversible.…”

Section: Resultsmentioning

confidence: 99%

Contactless Nanoparticle-Based Guiding of Cells by Controllable Magnetic Fields

Blümler¹,

Friedrich²,

Pereira³

et al. 2021

NSA

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Controlled and contactless movements of magnetic nanoparticles are crucial for fundamental biotechnological and clinical research (eg, cell manipulation and sorting, hyperthermia, and magnetic drug targeting). However, the key technological question, how to generate suitable magnetic fields on various length scales (µm–m), is still unsolved. Here, we present a system of permanent magnets which allows for steering of iron oxide nanoparticles (SPIONs) on arbitrary trajectories observable by microscopy. The movement of the particles is simply controlled by an almost force-free rotation of cylindrical arrangements of permanent magnets. The same instrument can be used to move suspended cells loaded with SPIONs along with predetermined directions. Surprisingly, it also allows for controlled movements of intracellular compartments inside of individual cells. The exclusive use of permanent magnets simplifies scaled up versions for animals or even humans, which would open the door for remotely controlled in vivo guidance of nanoparticles or micro-robots.

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Section: Resultsmentioning

confidence: 99%

Contactless Nanoparticle-Based Guiding of Cells by Controllable Magnetic Fields

Blümler¹,

Friedrich²,

Pereira³

et al. 2021

NSA

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Section: Some Experimental Resultsmentioning

confidence: 99%

“…The other prospective application of MNPs in biomedicine is neuron regeneration and growth engineering [ 73 , 136 , 137 ]. As shown in [ 136 ], the introduction of MNPs into neurons allows the control of the direction of axon growth by means of gradient MF. A similar effect, accompanied by the acceleration of cell differentiation as a result of growth hormone receptor stimulation, was reported in [ 137 ].…”

Section: Some Experimental Resultsmentioning

confidence: 99%

Non-Heating Alternating Magnetic Field Nanomechanical Stimulation of Biomolecule Structures via Magnetic Nanoparticles as the Basis for Future Low-Toxic Biomedical Applications

Golovin

Vlasova

et al. 2021

Nanomaterials

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The review discusses the theoretical, experimental and toxicological aspects of the prospective biomedical application of functionalized magnetic nanoparticles (MNPs) activated by a low frequency non-heating alternating magnetic field (AMF). In this approach, known as nano-magnetomechanical activation (NMMA), the MNPs are used as mediators that localize and apply force to such target biomolecular structures as enzyme molecules, transport vesicles, cell organelles, etc., without significant heating. It is shown that NMMA can become a biophysical platform for a family of therapy methods including the addressed delivery and controlled release of therapeutic agents from transport nanomodules, as well as selective molecular nanoscale localized drugless nanomechanical impacts. It is characterized by low system biochemical and electromagnetic toxicity. A technique of 3D scanning of the NMMA region with the size of several mm to several cm over object internals has been described.

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“…The authors showed that magnetized macrophages could form needle-shaped aggregates of cells containing intra-and extracellular SPIONs, and that this aggregation tendency increased while increasing SPION-loading per cell, and can be reversed by removing the magnetic fields. Long pole-ladder-like structures might be useful to model or engineering structures with unidirectional cellular growth, having potential for research in cellular barriers, capillaries, and neural communication pathways [246]. Cells labeled with SPIONs were placed in the magnetic arena and then guided on a square path by changing the direction of the quadrupole by 45 • every minute.…”

Section: Magnetic Guidance Of Cells 411 Magnetic Cell Manipulationmentioning

confidence: 99%

Micro/Nanosystems for Magnetic Targeted Delivery of Bioagents

et al. 2022

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Targeted delivery of pharmaceuticals is promising for efficient disease treatment and reduction in adverse effects. Nano or microstructured magnetic materials with strong magnetic momentum can be noninvasively controlled via magnetic forces within living beings. These magnetic carriers open perspectives in controlling the delivery of different types of bioagents in humans, including small molecules, nucleic acids, and cells. In the present review, we describe different types of magnetic carriers that can serve as drug delivery platforms, and we show different ways to apply them to magnetic targeted delivery of bioagents. We discuss the magnetic guidance of nano/microsystems or labeled cells upon injection into the systemic circulation or in the tissue; we then highlight emergent applications in tissue engineering, and finally, we show how magnetic targeting can integrate with imaging technologies that serve to assist drug delivery.

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Recent Advances in The Use of Magnetic Nanoparticles to Promote Neuroregeneration

Cited by 19 publications

References 20 publications

Contactless Nanoparticle-Based Guiding of Cells by Controllable Magnetic Fields

Contactless Nanoparticle-Based Guiding of Cells by Controllable Magnetic Fields

Non-Heating Alternating Magnetic Field Nanomechanical Stimulation of Biomolecule Structures via Magnetic Nanoparticles as the Basis for Future Low-Toxic Biomedical Applications

Micro/Nanosystems for Magnetic Targeted Delivery of Bioagents

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