Recent Advances in the Ugi Multicomponent Reactions

Alemán, J.; Cabrera, Silvia; Alvarado, Cuauhtémoc

doi:10.1002/9781118863992.ch7

Cited by 4 publications

(2 citation statements)

References 132 publications

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“…We critically evaluated the MCRs-functionalized materials based on the two synthetic routes; covalent and noncovalent functionalization through the different MCRs (Scheme ). As can be shown in Scheme , the functionalization modes through Ugi-4CR represent a significant part of the review, which because of the prominent and outstanding features of this isocyanide-based multicomponent reaction (I-MCR), its valuable pseudopeptide products, along with wide ranges of commercially available substrates …”

Section: Introductionmentioning

confidence: 99%

Materials Functionalization with Multicomponent Reactions: State of the Art

Afshari

Shaabani

2018

ACS Comb. Sci.

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The emergence of neoteric synthetic routes for materials functionalization is an interesting phenomenon in materials chemistry. In particular, the union of materials chemistry with multicomponent reactions (MCRs) opens a new avenue leading to the realm of highly innovative functionalized architectures with unique features. MCRs have recently been recognized as considerable part of the synthetic chemist's toolbox due to their great efficiency, inherent molecular diversity, atom and pot economy along with operational simplicity. Also, MCRs can improve E-factor and mass intensity as important green chemistry metrics. By rational tuning of the materials, as well as the MCRs, wide ranges of functionalized materials can be produced with tailorable properties that can play important roles in the plethora of applications. To date, there has not reported any exclusive review of a materials functionalization with MCRs. This critical review highlights the state-of-the-art on the one-pot functionalization of carbonaceous and siliceous materials, polysaccharides, proteins, enzymes, synthetic polymers, etc., via diverse kind of MCRs like Ugi, Passerini, Petasis, Khabachnik-Fields, Biginelli, and MALI reactions through covalent or noncovalent manners. Besides the complementary discussion of synthetic routes, superior properties and detailed applicability of each functionalized material in modern technologies are discussed. Our outlook also emphasizes future strategies for this unprecedented area and their use as materials for industrial implementation. With no doubt, MCRs-functionalization of materials bridges the gap between materials science domain and applied chemistry.

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Section: Introductionmentioning

confidence: 99%

Materials Functionalization with Multicomponent Reactions: State of the Art

Afshari

Shaabani

2018

ACS Comb. Sci.

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“…[9,10] En particular, los grupos de Zhu y Dömling han contribuido de manera significativa al avance de esta transformación. [11,12] Existen diversas metodologías de importancia en síntesis orgánica basadas en el uso de RMC's (ver Esquema 1), por ejemplo, la síntesis de aminoácidos de Strecker de 1850, de dihidropiridinas de Hantzsch en 1882, de dihidropirimidinas en 1891, la reacción de Mannich de 1912, entre otras. Todas estas reacciones han sido ampliamente explotadas en la química combinatoria y medicinal, por lo que se utilizan de manera común hoy en día, a pesar de que fueron descubiertas hace más de un siglo.…”

Section: Introductionunclassified

Síntesis de Ugi de tres componentes en presencia de metales de transición. Obtención de N-bencil-2-fenil-2-(fenilamino)acetamida

Puga Hernández,

Cuauhtémoc López,

Roa de la Fuente

et al. 2024

J. Basic Sci.

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Synthesis of Carboxamide‐Functionalized Multiwall Carbon Nanotubes via Ugi Multicomponent Reaction: Water‐Dispersible Peptidomimetic Nanohybrid as Controlled Drug Delivery Vehicle

Shaabani

Afshari

2017

ChemistrySelect

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This paper describes a direct synthesis of novel and valuable carboxamide functionalized multiwall carbon nanotubes (carboxamide-f-MWCNTs) for the development of new nanovectors through covalent functionalization via a one-pot four-component Ugi reaction. This efficient synthetic approach is facile and straightforward procedure for the synthesis of peptidomimetic coated MWCNTs from simple and readily starting materials including aniline, benzaldehyde, isocyanide and the carboxylated MWCNT as an acid component. The new synthesized nanobiohybrid was fully characterized. Also, the stability of nanobiohybrid was assessed using Zeta potential and particle size analyses. The synthesized nanobiohybrid presents unprecedented high and long term dispersity and stability in water. The performance of the nanobiohybrid for the controlled release of folic acid, as a model drug, was investigated and the results depicted pH dependent slow drug release behavior of nanobiohybrid. In addition, biocompatibility and cytotoxicity of carboxamide-f-MWCNTs were examined and no obvious adverse effects on the viability of NIH-3T3 cells were observed. The results manifested its valuable applicability in controlled release drug delivery systems.

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Recent Advances in the Ugi Multicomponent Reactions

Cited by 4 publications

References 132 publications

Materials Functionalization with Multicomponent Reactions: State of the Art

Materials Functionalization with Multicomponent Reactions: State of the Art

Síntesis de Ugi de tres componentes en presencia de metales de transición. Obtención de N-bencil-2-fenil-2-(fenilamino)acetamida

Synthesis of Carboxamide‐Functionalized Multiwall Carbon Nanotubes via Ugi Multicomponent Reaction: Water‐Dispersible Peptidomimetic Nanohybrid as Controlled Drug Delivery Vehicle

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