Recent advances in the synthesis and reactivity of quinoxaline

Abstract

Quinoxaline has become a subject of extensive research due to its emergence as an important chemical moiety possessing a wide range of physicochemical and biological activities. The last few decades...

Direct C‐2 arylation of quinoxaline with arylhydrazine salts as arylation reagents

“…Quinoxaline as an important class of nitrogen-containing heterocyclic compounds has attracted considerable attention in organic chemistry and pharmaceutical industry [1]. Diversely substituted quinoxalines have been shown a wide range of pharmacological activities (Figure 1), such as antitumors [2], antiviral [3], antioxidant [4], antibacterial [5], antiinflammatory [6], anticonvulsant [7], anticancer [8], antidepress [9,10], and antituberculosis [11].…”

Synthesis and Evaluation of Anticancer Activity of Pyrazolone Appended Triarylmethanes (TRAMs)

“…[38][39][40] Analysis and review of small molecules based on TRAM with potent anticancer activities has prompted us to design a pyrazolone ring containing triarylmethanes which aligns with our ongoing research project on designing and developing bioactive molecules as well as molecules for applications in biology. [41][42][43][44][45][46][47][48][49] It was interesting to note that several compounds are known in the literature, that possess a triphenylmethyl motif, appear to be potent anticancer agents. We, therefore, created a series of pyrazolone-appended hetero triarylmethane scaffolds.…”

“…Analysis and review of small molecules based on TRAM with potent anticancer activities has prompted us to design a pyrazolone ring containing triarylmethanes which aligns with our ongoing research project on designing and developing bioactive molecules as well as molecules for applications in biology [41–49] …”

Recent advances in the transition-metal-free synthesis of quinoxalines

“… 54 Also, Yashwantrao and Saha reviewed the synthesis and reactivity of quinoxaline derivatives. 55 The present review article focuses on the recent progress achieved in the synthesis of quinoxalines and their fused structure under transition-metal-free conditions and covers the literature from 2015 to date. Besides, highlighting the so far advances realized in this fascinating area, we also point out the limitations and drawbacks of the strategy, and their possible scope of future developments has also been discussed.…”