Recent advances in the study of toxicity of polymer-based nanomaterials

Prabha, A. Suriya; Dorothy, R.; Jancirani, S.; Rajendran, Susai; Singh, Gurmeet; Kumaran, S.

doi:10.1016/b978-0-12-819943-5.00007-5

Cited by 40 publications

(13 citation statements)

References 38 publications

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“…Last, many of these studies use relatively complex bottom up, low yield chemical syntheses and/or toxic organic solvents. Importantly, many of these materials (e.g., metallic nanomaterials, organic solvents, and synthetic polymers) could raise toxicity and environmental concerns if extensively applied in the field. − Therefore, the development of scalable, stimuli responsive synthesis platforms based on biodegradable nontoxic biopolymers and green solvents is of great importance for sustainable agrifood systems.…”

Section: Introductionmentioning

confidence: 99%

Enhancing Agrichemical Delivery and Plant Development with Biopolymer-Based Stimuli Responsive Core–Shell Nanostructures

Wang

Aytaç

et al. 2022

ACS Nano

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The inefficient delivery of agrichemicals in agrifood systems is among the leading cause of serious negative planetary and public health impacts. Such inefficiency is mainly attributed to the inability to deliver the agrichemicals at the right place (target), right time, and right dose. In this study, scalable, biodegradable, sustainable, biopolymer-based multistimuli responsive core−shell nanostructures were developed for smart agrichemical delivery. Three types of responsive core/ shell nanostructures incorporated with model agrichemicals (i.e., CuSO 4 and NPK fertilizer) were synthesized by coaxial electrospray, and the resulting nanostructures showed spherical morphology with an average diameter about 160 nm. Tunable agrichemical release kinetics were achieved by controlling the surface hydrophobicity of nanostructures. The pH and enzyme responsiveness was also demonstrated by the model analyte release kinetics (up to 7 days) in aqueous solution. Finally, the efficacy of the stimuli responsive nanostructures was evaluated in soil-based greenhouse studies using soybean and wheat in terms of photosynthesis efficacy and linear electron flow (LEF), two important metrics for seedling development and health. Findings confirmed plant specificity; for soybean, the nanostructures resulted in 34.3% higher value of relative chlorophyll content and 41.2% higher value of PS1 centers in photosystem I than the ionic control with equivalent agrichemical concentration. For wheat, the nanostructures resulted in 37.6% higher value of LEF than the ionic agrichemicals applied at 4 times higher concentration, indicating that the responsive core−shell nanostructure is an effective platform to achieve precision agrichemical delivery while minimizing inputs. Moreover, the Zn and Na content in the leaves of 4-week-old soybean seedlings were significantly increased with nanostructure amendment, indicating that the developed nanostructures can potentially be used to modulate the accumulation of other important micronutrients through a potential biofortification strategy.

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Section: Introductionmentioning

confidence: 99%

Enhancing Agrichemical Delivery and Plant Development with Biopolymer-Based Stimuli Responsive Core–Shell Nanostructures

Wang

Aytaç

et al. 2022

ACS Nano

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“…Polymeric nanoparticles are de ned in the size range of 1-1000 nm [10,32] and as the results from DLS and SEM analysis indicate, NPE particles show a size range between 70 and 1005 nm, and a PDI of 0.88 which signi es a wide range of size distribution and polydispersity. Since these particles are hydrophobic, they tend to bind together and therefore, it is deemed possible smaller particles join to form larger particles seen as two peaks in the DLS result (Fig.…”

Section: Discussionmentioning

confidence: 99%

Rapid Assay of Plastic Biodegradation Using Simply Fabricated Polyethylene Nanoparticles

hesami

Gharavi

Asgarani

et al. 2022

Preprint

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Synthetic polymers, such as polyethylene (PE), are produced daily in large quantities and due to their unique properties, like durability and low cost, consumed in various capacities around the world subsequently accumulating in terrestrial and marine environments. In recent years, the toxicological effects of these plastic particles on the environment, food chain, and public health as well as bioremediation approaches for the removal of these wastes has been the focus of several studies. Easy access to nano and micro sized PE particles in these approaches is crucial and urgent. In this research, we report a simple, fast, cost-effective method for the production of nano polyethylene particles (NPE) which are stable, capable of dispersion in water and without chemical modifications. PE particles were characterized by dynamic light scattering (DLS), X-ray diffraction (XRD), scanning electron microscopy (SEM) and Fourier Transform Infrared (FTIR) analysis. As a result, particles were made with a wide range of sizes 72-1005 nm (but mostly at size of 500 nm) with PDI of 0.88. The non-toxic nature of these nanoparticles for microorganisms were tested by MTT assay. The relevance of this method for the production of NPE is especially prominent in toxicity assessment studies which evaluate the effects of these particles in living organisms. Moreover, this method can be used to generate particles for efficient selection of PE-degrading microorganisms from the environment and scaled up for industrial use to facilitate the degradation process of PE and conversion of wastes to high-value products.

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“…Polymeric nanoparticles (PNPs) are colloidal solid particles or particulate dispersions with size that ranges from 1 to 1000 nm [ 258 , 259 , 260 ] that allows them to cross biological barriers [ 261 ]. The active compounds can be surface-adsorbed onto the polymeric core or entrapped within, and due to their high biocompatibility and ability to encapsulate compounds of different physicochemical properties, they are considered important carriers for plant ingredients [ 262 ].…”

Section: Organic-based Delivery Systemsmentioning

confidence: 99%

Innovative Delivery Systems Loaded with Plant Bioactive Ingredients: Formulation Approaches and Applications

Kyriakoudi

Spanidi²,

Mourtzinos

et al. 2021

Plants

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Plants constitute a rich source of diverse classes of valuable phytochemicals (e.g., phenolic acids, flavonoids, carotenoids, alkaloids) with proven biological activity (e.g., antioxidant, anti-inflammatory, antimicrobial, etc.). However, factors such as low stability, poor solubility and bioavailability limit their food, cosmetics and pharmaceutical applications. In this regard, a wide range of delivery systems have been developed to increase the stability of plant-derived bioactive compounds upon processing, storage or under gastrointestinal digestion conditions, to enhance their solubility, to mask undesirable flavors as well as to efficiently deliver them to the target tissues where they can exert their biological activity and promote human health. In the present review, the latest advances regarding the design of innovative delivery systems for pure plant bioactive compounds, extracts or essential oils, in order to overcome the above-mentioned challenges, are presented. Moreover, a broad spectrum of applications along with future trends are critically discussed.

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Recent advances in the study of toxicity of polymer-based nanomaterials

Cited by 40 publications

References 38 publications

Enhancing Agrichemical Delivery and Plant Development with Biopolymer-Based Stimuli Responsive Core–Shell Nanostructures

Enhancing Agrichemical Delivery and Plant Development with Biopolymer-Based Stimuli Responsive Core–Shell Nanostructures

Rapid Assay of Plastic Biodegradation Using Simply Fabricated Polyethylene Nanoparticles

Innovative Delivery Systems Loaded with Plant Bioactive Ingredients: Formulation Approaches and Applications

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