Recent advances in the role of endogenous hydrogen sulphide in cancer cells

Chen, Hao-Jie; Ke, Li; Qin, Yang-Zhe; Zhou, Jingjing; Li, Tao; Qian, Lei; Yang, Changyong; Ji, Xin‐Ying; Wu, Dongdong

doi:10.1111/cpr.13449

Cited by 4 publications

(3 citation statements)

References 175 publications

(365 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…What are the specific targets of H 2 S in the cell? Further exploring these questions could pave the way for developing therapeutic strategies to modulate H 2 S levels to treat various diseases [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

“…It enhances glucose uptake in peripheral tissues, contributing to overall glucose homeostasis. Furthermore, H 2 S plays a crucial role in mitochondrial function, influencing ATP synthesis and regulating metabolic energy production [ 42 ]. It modulates the activity of critical enzymes in glycolysis [ 43 ], gluconeogenesis, and the citric acid cycle, underscoring its role in maintaining metabolic homeostasis [ 44 , 45 , 46 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Hydrogen Sulfide: An Emerging Regulator of Oxidative Stress and Cellular Homeostasis—A Comprehensive One-Year Review

Munteanu,

Turnea,

Rotariu

2023

Antioxidants

View full text Add to dashboard Cite

Hydrogen sulfide (H2S), traditionally recognized as a toxic gas, has emerged as a critical regulator in many biological processes, including oxidative stress and cellular homeostasis. This review presents an exhaustive overview of the current understanding of H2S and its multifaceted role in mammalian cellular functioning and oxidative stress management. We delve into the biological sources and function of H2S, mechanisms underlying oxidative stress and cellular homeostasis, and the intricate relationships between these processes. We explore evidence from recent experimental and clinical studies, unraveling the intricate biochemical and molecular mechanisms dictating H2S’s roles in modulating oxidative stress responses and maintaining cellular homeostasis. The clinical implications and therapeutic potential of H2S in conditions characterized by oxidative stress dysregulation and disrupted homeostasis are discussed, highlighting the emerging significance of H2S in health and disease. Finally, this review underscores current challenges, controversies, and future directions in the field, emphasizing the need for further research to harness H2S’s potential as a therapeutic agent for diseases associated with oxidative stress and homeostatic imbalance. Through this review, we aim to emphasize H2S’s pivotal role in cellular function, encouraging further exploration into this burgeoning area of research.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hydrogen Sulfide: An Emerging Regulator of Oxidative Stress and Cellular Homeostasis—A Comprehensive One-Year Review

Munteanu,

Turnea,

Rotariu

2023

Antioxidants

View full text Add to dashboard Cite

show abstract

“…Apoptosis is an autonomous and orderly form of cell death that maintains the homeostatic balance within cells [ 47 ]. When apoptosis regulation is imbalanced, excessive apoptosis and cell death can cause severe damage to the body, often leading to the onset of diseases such as autoimmune disorders [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Quercetin Attenuates the Combined Effects of Zearalenone and Lipopolysaccharide on IPEC-J2 Cell Injury through Activating the Nrf2 Signaling Pathway

Wang,

Fu,

Wang

et al. 2023

Toxins

View full text Add to dashboard Cite

Zearalenone (ZEA) is a mycotoxin with an estrogen-like effect that is widely found in feed. Lipopolysaccharides (LPS) derived from Gram-negative bacteria are a common endotoxin, and both toxins have effects on human and livestock health. During animal feeding, ZEA as an exotoxin and LPS as an endotoxin have the potential to co-exist in organisms. At present, other studies have only focused on the hazards of single toxins, but there are fewer studies on the coexistence and interaction between ZEA and LPS. Therefore, a further study to investigate the combined toxic effects of different concentrations of ZEA and LPS is warranted. Quercetin (QUE) is a natural flavonoid compound with strong antioxidant and anti-inflammatory properties. It is unclear whether QUE can mitigate the combined effects of ZEA and LPS. IPEC-J2, isolated from the jejunum of non-breastfed neonatal piglets, is an ideal model for the study of epithelial cell transport, intestinal bacterial interactions, and the nutrient modulation of intestinal function. Therefore, the purpose of the present study was to demonstrate the effect of QUE in alleviating the combined toxic effect of ZEA and LPS on IPEC-J2 cell damage. Cell viability was measured after treating IPEC-J2 cells sequentially with 10, 20, 30, 40, 60, 80, and 100 μM ZEA, 1, 10, 50, and 100 μg/mL LPS, and 20, 40, 60, 80, 100, and 200 μM QUE for 24 h. Based on the cell viability results, 20 μM ZEA and 1 μg/mL LPS were selected as the most suitable concentrations for further analysis. For QUE, 20 μM increased the cell viability, while 40–200 μM QUE decreased the cell viability. Therefore, for the subsequent study, 20 μM QUE was selected in combination with 20 μM ZEA and 1 μg/mL LPS. The results showed that QUE increased the cellular viability and decreased the LDH content more compared to the effects of the ZEA+LPS group. At the gene level, QUE addition up-regulated the expression of Nrf2, HO-1, SOD2, and NQO1 at the gene or protein level compared to those of the ZEA+LPS group. The measurement of tight junction-related genes and proteins showed QUE up-regulated the expression of Claudin, ZO-1, and Occludin genes and proteins more than in the ZEA+LPS group. QUE addition reduced the rate of apoptosis more than that in the ZEA+LPS group. The expressions of Bcl-2 and Bax were examined at the gene level, and QUE addition significantly reduced the Bax gene expression level compared to that of the ZEA+LPS group, but there was no apparent variation in the expression level of Bcl-2. In summary, QUE can alleviate the combined toxic effects of ZEA and LPS on IPEC-J2 cells via modulating the Nrf2 signaling pathway, up-regulating the expression of antioxidative genes, and enhancing the intestinal barrier.

show abstract

Signal-on photoelectrochemical sensing by highly stable perovskite nanocrystals based on in situ formation of heterojunction

Zhang,

Zheng,

Chen

et al. 2024

Sensors and Actuators B: Chemical

View full text Add to dashboard Cite

Recent advances in the role of endogenous hydrogen sulphide in cancer cells

Cited by 4 publications

References 175 publications

Hydrogen Sulfide: An Emerging Regulator of Oxidative Stress and Cellular Homeostasis—A Comprehensive One-Year Review

Hydrogen Sulfide: An Emerging Regulator of Oxidative Stress and Cellular Homeostasis—A Comprehensive One-Year Review

Quercetin Attenuates the Combined Effects of Zearalenone and Lipopolysaccharide on IPEC-J2 Cell Injury through Activating the Nrf2 Signaling Pathway

Signal-on photoelectrochemical sensing by highly stable perovskite nanocrystals based on in situ formation of heterojunction

Contact Info

Product

Resources

About