Recent advances in the research of an endemic osteochondropathy in China: Kashin-Beck disease

Guo, Xiong; Ma, Wei-Juan; Zhang, Feng; Ren, Feng-Lin; Qu, Chengjuan; Lammi, Mikko J.

doi:10.1016/j.joca.2014.07.023

Cited by 165 publications

(144 citation statements)

References 59 publications

(39 reference statements)

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“…KBD primarily occurs in the northeast and southwest regions of China where selenium deficiency has been associated with the disease pathogenesis (4). To date, there are more than 0.66 million KBD patients in China, while less than 30 million residents are at risk in endemic areas (4,5).…”

Section: Introductionmentioning

confidence: 99%

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Comparative analysis of signaling pathways in peripheral blood from patients with Kashin-Beck disease and osteoarthritis

Ning

Wang

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. The aim of the present study was to investigate the early diagnostic biomarkers of Kashin-Beck disease (KBD), and to compare the common signaling pathways of peripheral mononuclear cells between patients with KBD and those with osteoarthritis (OA). A total of 20 and 12 peripheral blood samples were separately collected from KBD patients and normal control subjects, respectively, in an endemic area according to the diagnosis criteria. Total RNAs were extracted and gene expression levels were determined using an Agilent whole genome expression microarrays. The gene expression data of OA were obtained from GEO published database. Significant different pathways between KBD and OA were analyzed using Ingenuity Pathway Analysis software. A total of 82 differentially expressed genes, 51 significant different signaling pathways and five significant biological functions were identified in KBD patient samples, while 89, 50 and five significantly different genes, pathways and functions were identified in OA. Nine common significant pathways and five common differentially expressed genes were identified between the KBD and OA. Nine common significant pathways and five common differentially expressed genes were found between the two diseases. The present results suggest that there are similarities in vascular microcirculation, immunoreactions and cell apoptosis between KBD and OA, which may contribute to the early diagnosis and pathogenetic study of KBD.

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Section: Introductionmentioning

confidence: 99%

“…At present, diagnosis of KBD remains to be based on clinic manifestations and X-ray changes of metaphyseal (5). KBD may be classed as early, stage І, II and III, according to the severity (6).…”

Section: Introductionmentioning

confidence: 99%

Comparative analysis of signaling pathways in peripheral blood from patients with Kashin-Beck disease and osteoarthritis

Ning

Wang

et al. 2016

Experimental and Therapeutic Medicine

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“…Unlike other bone and joint diseases, for example, rheumatoid arthritis (RA), osteoarthritis (OA), reactive arthritis, and even septic arthritis, KBD showed obvious geographical features [1]. The characteristics of KBD are articular cartilage damage and chondrocytes apoptosis.…”

Section: Introductionmentioning

confidence: 99%

“…The characteristics of KBD are articular cartilage damage and chondrocytes apoptosis. KBD can affect many joints, and the most commonly affected joints are the knee, ankle, and hand [1,2]. Early investigations of KBD etiology and pathogenesis mainly focused on the effects of the endemic factors, such as selenium deficiency, cereal contamination by mycotoxin, and high humic acid levels in drinking water [2].…”

Section: Introductionmentioning

confidence: 99%

Role of inflammation in the process of clinical Kashin-Beck disease: latest findings and interpretations

Han

Wang

et al. 2015

Inflamm. Res.

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Kashin-Beck disease (KBD), a particular type of osteoarthritis (OA), and an endemic disease with articular cartilage damage and chondrocytes apoptosis, can affect many joints, and the most commonly affected joints are the knee, ankle, and hand. KBD has traditionally been classified as a non-inflammatory OA. However, recent studies have shown that inflammation has played an important role in the development of KBD. Nowadays, clinical KBD is not only an endemic disease, but also a combined result of many other non-endemic factors, which contains age, altered biomechanics, joint trauma and secondary OA. The characteristics of the developmental joint failure of advanced KBD, because of the biochemical and mechanical processes, are tightly linked with the interaction of joint damage and its immune response, as well as the subsequent state of chronic inflammation leading to KBD progression. In this review, we focus on the epidemiology, pathology, imaging, cytokines and transduction pathways investigating the association of inflammation with KBD; meanwhile, a wide range of data will be discussed to elicit our current hypotheses considering the role of inflammation and immune activation in KBD development.

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“…Fortunately, the incidence of KBD in children has fallen considerably over the past decades after comprehensive prevention measures. Nonetheless, 640,000 adults with KBD require treatment [4].…”

Section: Introductionmentioning

confidence: 99%

Reliability and validation of the joint dysfunction index as a new assessment instrument for therapeutic efficacy for Kashin-Beck disease

Xia

Hua

et al. 2016

Clin Rheumatol

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The objective of this study was to evaluate the reliability and validity of the joint dysfunction index (JDI) for assessment of therapeutic efficacy for Kashin-Beck disease (KBD). In an initial survey, completed questionnaires were obtained from 276 of 281 patients (98.2 %). A follow-up survey was completed with 64 KBD patients among 276 cases. A third survey selected 60 KBD patients who underwent intra-articular injection of sodium hyaluronate in the knees ascertained from the findings of the second questionnaire. Reliability was assessed using test-retest, "split-half" reliability and Cronbach's alpha coefficient. Factor analysis and item-to-domain correlation were used to analyze validity. The coefficient of variation (CV) was used to measure the sensitivity of scale. Feasibility assessment included consideration of completion time, rate of recovery, and time of completion. Reliability analysis comprised a test-retest correlation coefficient of 0.404-0.546 and a kappa test of 0.404-0.546. Internal consistency analysis comprised a Cronbach alpha coefficient of 0.689 and a split-half coefficient of 0.677. Principal component factor analysis for validity testing extracted a common factor with a cumulative variance contribution of 45.44 %. The JDI score from 276 KBD cases revealed no significant difference associated with age, gender, education, or the body mass index. Sensitivity analysis showed that there was no significant difference between pre-treatment and post-treatment values, with a CV of 96.55-172.06 %. In conclusion, the JDI can be used to evaluate the efficacy of agents used to treat KBD.

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Recent advances in the research of an endemic osteochondropathy in China: Kashin-Beck disease

Cited by 165 publications

References 59 publications

Comparative analysis of signaling pathways in peripheral blood from patients with Kashin-Beck disease and osteoarthritis

Comparative analysis of signaling pathways in peripheral blood from patients with Kashin-Beck disease and osteoarthritis

Role of inflammation in the process of clinical Kashin-Beck disease: latest findings and interpretations

Reliability and validation of the joint dysfunction index as a new assessment instrument for therapeutic efficacy for Kashin-Beck disease

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