Recent advances in the protective role of hydrogen sulfide in myocardial ischemia/reperfusion injury

Zhang, Meng-Ling; Peng, Wei; Ni, Jielei; Chen, Gang

doi:10.4103/2045-9912.311499

Cited by 16 publications

(7 citation statements)

References 56 publications

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“…Consequently, the cell extrudes Na + in exchange for Ca 2+ by the Na + /Ca 2+ exchanger. The surplus Ca 2+ , flowing into the mitochondria, may activate the Ca 2+ /calmodulin-dependent protein kinases pathologically [ 3 ]. A recent study considered that the IRI promoted the production of proinflammatory cytokines and induced proapoptotic pathways of the unfolded protein response (UPR) [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Decreased Spp1 Expression in Acute Myocardial Infarction after Ischemia and Reperfusion Injury

Huang

Zhao

et al. 2021

Cardiology Research and Practice

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Background. With the progress of shock therapy and the establishment and promotion of methods such as thrombolytic therapy and percutaneous coronary intervention (PCI), many tissues and organs have been reperfused after ischemia which may cause even worse disorder called ischemia-reperfusion injury (IRI). mRNAs have been found to have significant impacts on ischemia-reperfusion through various mechanisms. In view of the accessibility of mRNAs from blood, we aimed to find the association between mRNA and ischemia-reperfusion. Methods. We used the GSE83472 dataset from the Gene Expression Omnibus (GEO) database to find differential RNA expression between ischemia-reperfusion tissue and control samples. In addition, Gene Ontology (GO) annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed to find the biological property of 449 RNAs from GSE83472 via the Database for Annotation, Visualization, and Integrated Discovery (DAVID). Besides, Gene Set Enrichment Analysis (GSEA), a tool to find the pathway orientation of a gene set, was used for further study in the four most significant KEGG pathways. Furthermore, we constructed a protein-protein interaction (PPI) network. In the end, we used quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and western blotting to measure and compare the expression of Spp1 in patients who accepted percutaneous coronary intervention. Results. The bioinformatics analyses suggested that Spp1 was a hub gene in reperfusion after ischemia. The qRT-PCR result showed that the Spp1 expression was significantly downregulated in ischemia-reperfusion cells after PCI compared with normal samples and so as the western blotting. Conclusion. Spp1 might play an essential role in acute myocardial infarction after ischemia and reperfusion injury.

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Section: Introductionmentioning

confidence: 99%

Decreased Spp1 Expression in Acute Myocardial Infarction after Ischemia and Reperfusion Injury

Huang

Zhao

et al. 2021

Cardiology Research and Practice

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“…Pathophysiological consequences of the H 2 S/O 2 axis. Additional details can be found in a number of recent reviews [ 166 , 167 , 168 , 169 , 170 , 171 , 172 , 173 , 174 , 175 , 176 , 177 ].…”

Section: Evidence For H 2 S Mediated O 2 Sensing In Various Organ Systems and Tissuesmentioning

confidence: 99%

A Case for Hydrogen Sulfide Metabolism as an Oxygen Sensing Mechanism

Olson

2021

Antioxidants

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The ability to detect oxygen availability is a ubiquitous attribute of aerobic organisms. However, the mechanism(s) that transduce oxygen concentration or availability into appropriate physiological responses is less clear and often controversial. This review will make the case for oxygen-dependent metabolism of hydrogen sulfide (H2S) and polysulfides, collectively referred to as reactive sulfur species (RSS) as a physiologically relevant O2 sensing mechanism. This hypothesis is based on observations that H2S and RSS metabolism is inversely correlated with O2 tension, exogenous H2S elicits physiological responses identical to those produced by hypoxia, factors that affect H2S production or catabolism also affect tissue responses to hypoxia, and that RSS efficiently regulate downstream effectors of the hypoxic response in a manner consistent with a decrease in O2. H2S-mediated O2 sensing is then compared to the more generally accepted reactive oxygen species (ROS) mediated O2 sensing mechanism and a number of reasons are offered to resolve some of the confusion between the two.

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“… 2 , 3 Among these cardiac adaptive and/or pathological alterations, cardiomyocyte responses, particularly in intracellular homeostasis maintenance during hypoxia, are the critical molecular basis that determines the adaptive cardiac outcomes. 4 , 5 …”

Section: Introductionmentioning

confidence: 99%

Mitochondria-associated membrane protein PACS2 maintains right cardiac function in hypobaric hypoxia

Yang¹,

Sun²,

Chen³

et al. 2023

iScience

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Recent advances in the protective role of hydrogen sulfide in myocardial ischemia/reperfusion injury

Cited by 16 publications

References 56 publications

Decreased Spp1 Expression in Acute Myocardial Infarction after Ischemia and Reperfusion Injury

Decreased Spp1 Expression in Acute Myocardial Infarction after Ischemia and Reperfusion Injury

A Case for Hydrogen Sulfide Metabolism as an Oxygen Sensing Mechanism

Mitochondria-associated membrane protein PACS2 maintains right cardiac function in hypobaric hypoxia

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